Results 141 to 150 of about 12,077 (249)
Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda +14 more
wiley +2 more sources
Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions
MedComm, Volume 7, Issue 8, August 2026.This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei +9 more
wiley +1 more source
The role of fatty acid metabolism in acute lung injury: a special focus on immunometabolism
Cellular and Molecular Life SciencesReputable evidence from multiple studies suggests that excessive and uncontrolled inflammation plays an indispensable role in mediating, amplifying, and protracting acute lung injury (ALI).
Xiao Lu +7 more
semanticscholar +1 more source
Small Science, Volume 6, Issue 8, August 2026.Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu +3 more
wiley +1 more source
Aging Cell, Volume 25, Issue 8, August 2026.Microglia, the brain's resident macrophages, undergo metabolic reprogramming during aging, which impacts brain health and neurodegenerative disease risk. Understanding mechanisms of microglial metabolic regulation is key to the development of therapeutic strategies to promote homeostasis and mitigate harmful neuroinflammatory processes that contribute ...
Seokjo Kang, Helen S. Goodridge
wiley +1 more source
An ANGPTL8‐AKT2‐mTOR Axis Drives Adipose Senescence and Aging‐Related Functional Decline
Aging Cell, Volume 25, Issue 8, August 2026.ANGPTL8 increases with age in humans and mice and serves as a key predictor of biological aging and mortality. Adipocyte‐derived ANGPTL8 promotes cellular senescence through AKT2–mTOR signaling, whereas genetic deletion of Angptl8 attenuates adipose tissue aging and extends lifespan.
Yi He +11 more
wiley +1 more source
Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley +1 more source
Liver International, Volume 46, Issue 8, August 2026.ABSTRACT Background and Aims Prognostic biomarkers that link disease progression and/or responses to therapeutic interventions in patients with primary biliary cholangitis (PBC) remain undefined. In this study, we used a machine learning (ML) approach with whole‐blood transcriptomic data to predict clinical outcomes in response to obeticholic acid (OCA)
Hussain Syed +10 more
wiley +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
wiley +1 more source
A new twist in metabolic T cell exhaustion. [PDF]
Immunometabolism (Cobham)Aliazis K, Boussiotis VA.
europepmc +1 more source