Results 81 to 90 of about 15,033 (230)
MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells
Scientific Reports, 2020 MZB1 is an endoplasmic reticulum (ER)-resident protein that plays an important role in the humoral immune response by enhancing the interaction of the μ immunoglobulin (Ig) heavy chain with the chaperone GRP94 and by augmenting the secretion of IgM. Here,
Tanya Kapoor +4 more
doaj +1 more source
Transcriptome Modifications in Porcine Adipocytes via Toll-Like Receptors Activation [PDF]
, 2019 Adipocytes are the most important cell type in adipose tissue playing key roles in immunometabolism. We previously reported that nine members of the Toll-like receptor (TLR) family are expressed in an originally established porcine intramuscular pre ...
Albarracín, Leonardo Miguel +13 more
core +1 more source
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. [PDF]
, 2020 The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood.
Cavrois, Marielle +16 more
core +1 more source
British Journal of Haematology, EarlyView.Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu +8 more
wiley +1 more source
Exercise training alters circadian clock dynamics in cancer‐bearing male mice
Physiological ReportsAlterations in circadian timing mechanisms are increasingly recognized as contributing to tumor initiation and progression. Moreover, evidence indicates that malignant cells can interfere with the expression and synchronization of core clock genes ...
Loreana Sanches Silveira +3 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, offering improvements in survival across various malignancies. However, their toxicities pose a major challenge for cardio‐oncology units. Despite their growing importance, data on effectiveness of such specialized units in mitigating ICI‐associated ...
Elias Haj‐Yehia +6 more
wiley +1 more source
Immunometabolic reprogramming, another cancer hallmark
Frontiers in Immunology, 2023 Molecular carcinogenesis is a multistep process that involves acquired abnormalities in key biological processes. The complexity of cancer pathogenesis is best illustrated in the six hallmarks of the cancer: (1) the development of self-sufficient growth signals, (2) the emergence of clones that are resistant to apoptosis, (3) resistance to the ...
Vijay Kumar +2 more
openaire +3 more sources
Immunometabolism in the pathogenesis of vitiligo
Frontiers in Immunology, 2022 Vitiligo is a common depigmenting skin disorder characterized by the selective loss of melanocytes. Autoimmunity, genetic, environmental, and biochemical etiology have been proposed in vitiligo pathogenesis.
Chen Lyu, Yonghu Sun
doaj +1 more source
The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
Role of Lactate in Inflammatory Processes: Friend or Foe
Frontiers in Immunology, 2022 During an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH drop in the inflamed tissue is largely attributed to the presence of lactate by an increase in ...
Carolina Manosalva +8 more
doaj +1 more source