Results 81 to 90 of about 12,525 (189)
SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
The Journal of Physiology, EarlyView.Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
Medical SciencesIntroduction: Ultra-processed foods (UPFs) are characterized by high levels of additives such as sugars, fats, and preservatives and, due to their composition, represent a major public health concern, being associated with several adverse effects ...
Sofia Morais Tornis +5 more
doaj +1 more source
Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu +2 more
wiley +1 more source
Raman micro-spectroscopy as a tool to study immunometabolism [PDF]
In the past two decades, immunometabolism has emerged as a crucial field, unraveling the intricate molecular connections between cellular metabolism and immune function across various cell types, tissues, and diseases.
Xu, Jiabao +2 more
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Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease
Acta Physiologica, Volume 242, Issue 11, November 2026.ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley +1 more source
Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis
Immunology, Volume 179, Issue 3, Page 418-433, November 2026.Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao +16 more
wiley +1 more source
Cancer immunometabolism: advent, challenges, and perspective
Molecular CancerFor decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive ...
Qin Dang +14 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2020 Chronic inflammation is a causative factor of many cancers, although it originally acts as a protective host response to the loss of tissue homeostasis. Many inflammatory conditions predispose susceptible cells, most of which are of epithelial origin, to
Cuimeng Tian MD +5 more
doaj +1 more source
Immunology, Volume 179, Issue 3, Page 486-515, November 2026.In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque +11 more
wiley +1 more source
T Cells in Adipose Tissue: Critical Players in Immunometabolism [PDF]
, 2018 Adipose tissue performs immunoregulatory functions in addition to fat storage. Various T cells in different fat depots either help maintain metabolic homeostasis under healthy conditions or contribute to metabolic disorders in pathological conditions ...
Qun Wang, Huaizhu Wu
core +1 more source