Results 11 to 20 of about 2,007,152 (308)

Macrophage Activation Syndrome [PDF]

Hematology/Oncology Clinics of North America, 2015
Macrophage activation syndrome (MAS) is a potentially life-threatening complication of rheumatic diseases such as systemic juvenile idiopathic arthritis (sJIA) and systemic lupus erythematosus. It is often considered a type of secondary hemophagocytic lymphohistiocytosis (HLH) and results from over-activation of T lymphocytes and macrophages leading to
Alberto Martini, Angelo Ravelli, Francesca Minoia   +2 more
exaly   +7 more sources

A Review on Macrophage Activation Syndrome

Journal of Pure and Applied Microbiology, 2019
MAS, which is currently grouped under secondary or acquired haemophagocytic lymphohistiocytosis (sHLH), is a rare and fatal disorder that results from excess activation of T-cells and macrophages.
Preeti Sharma, Shailza Shreshtha, Pradeep Kumar, Rachna Sharma, T.K. Mahapatra   +4 more
doaj   +2 more sources

RANKL promotes airway inflammation via pro-inflammatory alveolar macrophage activation in COPD [PDF]

Respiratory Research
Background Chronic airway inflammation is a key mechanism involved in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD).
Lu Zhou, Baiquan Zhang, Huanqin Wang, Jintao Liu, Lijun Miao   +4 more
doaj   +2 more sources

Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish

Frontiers in Immunology, 2021
Immediately after a wound, macrophages are activated and change their phenotypes in reaction to danger signals released from the damaged tissues. The cues that contribute to macrophage activation after wounding in vivo are still poorly understood ...
Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Groß, Felix Ellett, Felix Ellett, Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla, Mai Nguyen-Chi   +9 more
doaj   +1 more source

Solanum nigrum induces macrophage activation through TLR4-mediated activation of JNK and macrophage autophagy through TLR4-mediated activation of p38 and JNK

Food and Agricultural Immunology, 2022
In this study, we investigated the effect of Solanum nigrum aerial parts (SNAP) on macrophage activation and macrophage autophagy in RAW264.7 cells. SNAP increased the production of immunostimulatory factors and phagocytosis in RAW264.7 cells.
Ju Hyung Yu, Min Yeong Choi, So Jung Park, Na Gyeong Geum, Jae Won Lee, Gwang Hun Park, Hyun Ji Eo, Jin Boo Jeong   +7 more
doaj   +1 more source

ARRB1 suppresses the activation of hepatic macrophages via modulating endoplasmic reticulum stress in lipopolysaccharide-induced acute liver injury

Cell Death Discovery, 2021
Acute liver injury (ALI) caused by multiple inflammatory responses is a monocyte-/macrophage-mediated liver injury that is associated with high morbidity and mortality. Liver macrophage activation is a vital event that triggers ALI.
Yiming Lei, Sizhe Wan, Huiling Liu, Haoxiong Zhou, Lingjun Chen, Yidong Yang, Bin Wu   +6 more
doaj   +1 more source

In Vitro Screening Method for Characterization of Macrophage Activation Responses

Methods and Protocols, 2022
Macrophage activation refers to the enhanced functionality of macrophages in response to endogenous or exogenous stimuli. Due to the existence of limitless stimuli and a multitude of receptors on macrophage surfaces, the nature of activation (or acquired
Brandon W. Lewis, Sonika Patial, Yogesh Saini   +2 more
doaj   +1 more source

Neuropathology in COVID-19 autopsies is defined by microglial activation and lesions of the white matter with emphasis in cerebellar and brain stem areas

Frontiers in Neurology, 2023
IntroductionThis study aimed to investigate microglial and macrophage activation in 17 patients who died in the context of a COVID-19 infection in 2020 and 2021.MethodsThrough immunohistochemical analysis, the lysosomal marker CD68 was used to detect ...
Julian A. Stein, Manuel Kaes, Sigrun Smola, Sigrun Smola, Walter J. Schulz-Schaeffer   +4 more
doaj   +1 more source

Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages

Frontiers in Molecular Biosciences, 2021
Macrophage activation is an important process in controlling infection, but persistent macrophage activation leads to chronic inflammation and diseases, such as tumor progression, insulin resistance and atherosclerosis.
Jing Liu, Zhaoyun Zong, Wenhao Zhang, Yuling Chen, Xueying Wang, Jie Shen, Changmei Yang, Xiaohui Liu, Haiteng Deng   +8 more
doaj   +1 more source

Activation of Murine Macrophages [PDF]

Current Protocols in Immunology, 2008
AbstractOur understanding of cell mediated immunity (CMI) has revealed the importance of activated macrophages as key immune effector cells. Over the past decade, we have come to realize that macrophages exhibit remarkable plasticity, and different populations of macrophages with distinct physiologies can develop in response to different stimuli.
David M, Mosser, Xia, Zhang
openaire   +2 more sources