Metabolism fine-tunes macrophage activation
eLife, 2016 A signaling pathway that rewires metabolism in macrophages to trigger changes in gene expression has been identified.
AnnMarie Torres +2 more
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Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]
, 2004 Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R +34 more
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Macrophage activation syndrome in COVID-19
Акушерство, гинекология и репродукция, 2021 The novel coronavirus epidemic is characterized by high rates of morbidity and relatively high mortality. Laboratory test results in patients include leukopenia, an increase in liver function tests and ferritin levels reaching hundreds, and sometimes ...
K. N. Grigorieva +11 more
doaj +1 more source
Metabolic Regulation of Macrophage Activation
Journal of Innate Immunity, 2021 Macrophages, the central mediators of innate immune responses, being in the first-line of defense, they have to readily respond to pathogenic or tissue damage signals to initiate the inflammatory cascade.
Ourania Kolliniati +3 more
doaj +1 more source
Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages [PDF]
, 2018 open11noSeveral studies suggest that curcumin and related compounds possess antioxidant and anti-inflammatory properties including modulation of lipopolysaccharide- (LPS-) mediated signalling in macrophage cell models. We here investigated the effects of
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Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. [PDF]
, 2015 Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant in mouse and human CP.
Chawla, Ajay +6 more
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Estrogen, angiogenesis, immunity and cell metabolism: Solving the puzzle [PDF]
, 2018 Estrogen plays an important role in the regulation of cardiovascular physiology and the immune system by inducing direct effects on multiple cell types including immune and vascular cells. Sex steroid hormones are implicated in cardiovascular protection,
Bolego, Chiara +5 more
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Scientific Reports, 2021 Hyperactivation of the immune system through obesity and diabetes may enhance infection severity complicated by Acute Respiratory Distress Syndrome (ARDS).
Abu Saleh Md Moin +4 more
doaj +1 more source
Macrophage-derived upd3 Cytokine causes impaired glucose homeostasis and reduced lifespan in drosophila fed a lipid-rich diet [PDF]
, 2014 Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that ...
Dionne, MS +5 more
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Activation of Macrophages by Peroxidases
Experimental Biology and Medicine, 1986 Peritoneal macrophages from C57BL/6 mice were activated in vitro with various peroxidases and their cytotoxic activity toward 3T12 cells was determined. Destruction of 3T12 cells by macrophages stimulated with horseradish peroxidase, lactoperoxidase, and microperoxidase was observed at peroxidase concentrations as low as 9, 1.6, and 200 nM ...
R Q, Wei +3 more
openaire +2 more sources