Results 51 to 60 of about 646,237 (202)

Identification of Grb2 protein as a potential mediator of macrophage activation in acute pancreatitis based on bioinformatics and experimental verification

Frontiers in Immunology
IntroductionMacrophage activation is closely associated with Acute pancreatitis (AP). We screened and found that Growth factor receptor bound protein 2 (Grb2) is highly expressed in macrophages during AP.
Qinhao Shen, Shuai Wang, Keyan Wu, Liuhui Wang, Weijuan Gong, Guotao Lu, Weiwei Chen, Chenchen Yuan, Bo Tu, Wei Li, Yaodong Wang, Weixuan Yang   +11 more
doaj   +1 more source

Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection.

PLoS Genetics, 2015
Macrophages display flexible activation states that range between pro-inflammatory (classical activation) and anti-inflammatory (alternative activation). These macrophage polarization states contribute to a variety of organismal phenotypes such as tissue
Musa A Hassan, Kirk D Jensen, Vincent Butty, Kenneth Hu, Erwan Boedec, Pjotr Prins, Jeroen P J Saeij   +6 more
doaj   +1 more source

Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury

Cell Death Discovery, 2023
Aged livers have shown aggravated liver ischemia and reperfusion (IR) injury. Timely efferocytosis of apoptotic cells is a key mechanism for avoiding excessive inflammation and tissue injury.
Haoran Hu, Xuyu Cheng, Fei Li, Zhu Guan, Jian Xu, Dongming Wu, Yiyun Gao, Xinyu Zhan, Ping Wang, Haoming Zhou, Zhuqing Rao, Feng Cheng   +11 more
doaj   +1 more source

Macrophages in wound healing: activation and plasticity. [PDF]

, 2019
Macrophages are critically involved in wound healing, from dampening inflammation to clearing cell debris and coordinating tissue repair. Within the wound, the complexity of macrophage function is increasingly recognized, with adverse outcomes when ...
Kim, Sang Yong, Nair, Meera G
core  

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

Frontiers in Immunology, 2020
Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate immune responses in cancer. This study investigated the mechanisms by which lactate suppresses macrophage pro-inflammatory responses. Macrophages [Raw 264.7
Kun Yang, Kun Yang, Jingjing Xu, Min Fan, Min Fan, Fei Tu, Fei Tu, Xiaohui Wang, Tuanzhu Ha, Tuanzhu Ha, David L. Williams, David L. Williams, Chuanfu Li, Chuanfu Li   +13 more
doaj   +1 more source

XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression

JHEP Reports, 2022
Background & Aims: XBP1 modulates the macrophage proinflammatory response, but its function in macrophage stimulator of interferon genes (STING) activation and liver fibrosis is unknown.
Qi Wang, Qingfa Bu, Mu Liu, Rui Zhang, Jian Gu, Lei Li, Jinren Zhou, Yuan Liang, Wantong Su, Zheng Liu, Mingming Wang, Zhexiong Lian, Ling Lu, Haoming Zhou   +13 more
doaj   +1 more source

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. [PDF]

, 2019
Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown.
Edgerton, V Reggie, Hara, Masamitsu, Harimaya, Katsumi, Inoue, Kazuhide, Iwamoto, Yukihide, Kijima, Ken, Kobayakawa, Kazu, Kubota, Kensuke, Masuda, Takahiro, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Ohkawa, Yasuyuki, Okada, Seiji, Ozato, Keiko, Saito, Takeyuki, Tamaru, Tetsuya, Tamura, Tomohiko, Tsuda, Makoto, Yokota, Kazuya, Yoshizaki, Shingo   +19 more
core   +1 more source

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. [PDF]

, 2014
Low-grade systemic inflammation is often associated with metabolic syndrome, which plays a critical role in the development of the obesity-associated inflammatory diseases, including insulin resistance and atherosclerosis.
DeFranco, Anthony L, Dicorleto, Paul E, Febbraio, Maria, Fox, Paul L, Harding, Clifford V, Hazen, Stanley L, Hise, Amy G, Hu, Bingqing, Li, Xiaoxia, Morton, Richard E, Nagy, Laura E, Ransohoff, Richard M, Roychowdhury, Sanjoy, Schmitt, David, Smith, Jonathan D, Wang, Jian-an, Xiao, Nengming, Yu, Minjia, Zhao, Junjie, Zhou, Hao   +19 more
core   +2 more sources

TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling

JHEP Reports, 2023
Background & Aims: Oxidative stress-mediated ferroptosis and macrophage-related inflammation play an important role in various liver diseases. Here, we explored if and how hepatocyte ferroptosis regulates macrophage stimulator of interferon genes ...
Wantong Su, Weicheng Gao, Rui Zhang, Qi Wang, Lei Li, Qingfa Bu, Zibo Xu, Zheng Liu, Mingming Wang, Yaqing Zhu, Guoping Wu, Haoming Zhou, Xun Wang, Ling Lu   +13 more
doaj   +1 more source

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. [PDF]

, 2017
Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy.
Castegna, Alessandra, De Tullio, Giacoma, Ghesquière, Bart, Guarini, Attilio, Hooper, D Craig, Lamers, Wouter H., Martín-Pérez, Rosa, Mazzone, Massimiliano, McVicar, Daniel W., Menga, Alessio, Palmieri, Erika M., Quinto, Annamaria, Riera-Domingo, Carla   +12 more
core   +5 more sources