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Reversibility of liver fibrosis [PDF]
Clinics and Research in Hepatology and Gastroenterology, 2015 Liver fibrosis is a serious health problem worldwide, which can be induced by a wide spectrum of chronic liver injuries. However, until today, there is no effective therapy available for liver fibrosis except the removal of underlying etiology or liver transplantation. Recent studies indicate that liver fibrosis is reversible when the causative agent(s)
Mengxi Sun, Tatiana Kisseleva
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Biomarkers of liver fibrosis [PDF]
Clinical Liver Disease, 2016 Currently the only accepted method (gold standard) for the diagnosis of the fibrotic stages of chronic liver disease (CLD) is liver biopsy, to allow histological assessment. Liver biopsy is an invasive investigation associated with a range adverse events (e.g. pain, haemorrhage) limiting its serial usage in clinical practice.
Morling, Joanne R., Guha, Indra Neil
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Cells, 2019 An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological
Giuseppe Mazza +26 more
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Diagnostics, 2023 (1) Background: This study aimed to correlate the indocyanine green clearance (ICG) test with histopathological grades of liver fibrosis and liver cirrhosis to assess its diagnostic accuracy in differentiating normal liver parenchyma from liver fibrosis ...
Lukas Luerken +9 more
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Reversibility of liver fibrosis [PDF]
Fibrogenesis & Tissue Repair, 2012 Liver fibrosis, and its end stage cirrhosis are a major cause of morbidity and mortality and therapeutic options are limited. However, the traditional view of liver disease as an irreversible process is obsolete and it is now evident that the development of liver fibrosis is a dynamic and potentially bidirectional process.
Pellicoro, Antonella +2 more
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The role of hepatic microenvironment in hepatic fibrosis development
Annals of Medicine, 2022 Aim Fibrosis is a common pathological feature of most types of chronic liver injuries. There is no specific treatment for liver fibrosis at present. The liver microenvironment, which fosters the survival and activity of liver cells, plays an important ...
Ying Meng +3 more
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Hypoxia-induced factor and its role in liver fibrosis [PDF]
PeerJ, 2022 Liver fibrosis develops as a result of severe liver damage and is considered a major clinical concern throughout the world. Many factors are crucial for liver fibrosis progression.
Jan Mohammad Omar, Yang Hai, Shizhu Jin
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Saudi Journal of Gastroenterology, 2009 Hepatic fibrosis is a scarring process associated with an increased and altered deposition of extracellular matrix in the liver. It is caused by a variety of stimuli and if fibrosis continues unopposed, it would progress to cirrhosis which poses a significant health problem worldwide.
Ismail Mona, Pinzani Massimo
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Journal of Diabetes Investigation, 2022 Aims/Introduction To investigate whether the Fibrosis‐4 index can help stratify the risk of diabetes mellitus in patients with fatty liver disease.
Yasuhiko Todo +19 more
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Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: Liver fibrosis/cirrhosis is significant health burden worldwide, resulting in liver failure or cancer and accounting for many deaths each year.
Xiaolei Li +6 more
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