Results 21 to 30 of about 490,020 (307)

Heparanase and macrophage interplay in the onset of liver fibrosis [PDF]

, 2017
The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed at investigating the ...
Crescenzi, Marika, Floreani, Annarosa, Masola, Valentina, Onisto, Maurizio, Russo, Francesco Paolo, Secchi, Maria Francesca   +5 more
core   +2 more sources

Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition

Cells, 2019
An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological
Giuseppe Mazza, Andrea Telese, Walid Al-Akkad, Luca Frenguelli, Ana Levi, Martina Marrali, Lisa Longato, Kessarin Thanapirom, Maria Giovanna Vilia, Benedetta Lombardi, Claire Crowley, Mark Crawford, Morten A. Karsdal, Diana J. Leeming, Giusi Marrone, Katrin Bottcher, Benjamin Robinson, Armando Del Rio Hernandez, Domenico Tamburrino, Gabriele Spoletini, Massimo Malago, Andrew R. Hall, Jasminka Godovac-Zimmermann, Tu Vinh Luong, Paolo De Coppi, Massimo Pinzani, Krista Rombouts   +26 more
doaj   +1 more source

Diagnostic Accuracy of Indocyanine Green Clearance Test for Different Stages of Liver Fibrosis and Cirrhosis

Diagnostics, 2023
(1) Background: This study aimed to correlate the indocyanine green clearance (ICG) test with histopathological grades of liver fibrosis and liver cirrhosis to assess its diagnostic accuracy in differentiating normal liver parenchyma from liver fibrosis ...
Lukas Luerken, Marco Dollinger, Andrea Goetz, Kirstin Utpatel, Michael Christian Doppler, Jakob Benedikt Weiss, Wibke Uller, André Ignee, Niklas Verloh, Michael Haimerl   +9 more
doaj   +1 more source

A Prospective Study of Long-term Outcomes in Female Patients with Nonalcoholic Steatohepatitis Using Age- and Body Mass Index-matched Cohorts [PDF]

, 2013
In patients with nonalcoholic steatohepatitis (NASH), the prevalence of cirrhosis is higher among women than men, and hepatocellular carcinoma (HCC) develops mainly in the cirrhotic stage among women.
Hashizume, Hiroaki, Horiguchi, Norio, Kakizaki, Satoru, Mori, Masatomo, Sato, Ken, Yamazaki, Yuichi   +5 more
core   +1 more source

The role of hepatic microenvironment in hepatic fibrosis development

Annals of Medicine, 2022
Aim Fibrosis is a common pathological feature of most types of chronic liver injuries. There is no specific treatment for liver fibrosis at present. The liver microenvironment, which fosters the survival and activity of liver cells, plays an important ...
Ying Meng, Tong Zhao, Zhengyi Zhang, Dekui Zhang   +3 more
doaj   +1 more source

Combined evaluation of Fibrosis‐4 index and fatty liver for stratifying the risk for diabetes mellitus

Journal of Diabetes Investigation, 2022
Aims/Introduction To investigate whether the Fibrosis‐4 index can help stratify the risk of diabetes mellitus in patients with fatty liver disease.
Yasuhiko Todo, Teruki Miyake, Shinya Furukawa, Bunzo Matsuura, Toru Ishihara, Masumi Miyazaki, Akihito Shiomi, Hironobu Nakaguchi, Sayaka Kanzaki, Yasunori Yamamoto, Yohei Koizumi, Osamu Yoshida, Yoshio Tokumoto, Masashi Hirooka, Eiji Takeshita, Teru Kumagi, Yoshio Ikeda, Masanori Abe, Takeru Iwata, Yoichi Hiasa   +19 more
doaj   +1 more source

GDF15 Ameliorates Liver Fibrosis by Metabolic Reprogramming of Macrophages to Acquire Anti-Inflammatory PropertiesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Liver fibrosis/cirrhosis is significant health burden worldwide, resulting in liver failure or cancer and accounting for many deaths each year.
Xiaolei Li, Qian Huai, Cheng Zhu, Xu Zhang, Wentao Xu, Hanren Dai, Hua Wang   +6 more
doaj   +1 more source

Hypoxia-induced factor and its role in liver fibrosis [PDF]

PeerJ, 2022
Liver fibrosis develops as a result of severe liver damage and is considered a major clinical concern throughout the world. Many factors are crucial for liver fibrosis progression.
Jan Mohammad Omar, Yang Hai, Shizhu Jin
doaj   +2 more sources

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing. [PDF]

, 2017
Fibrotic diseases contribute to 45% of deaths in the industrialized world, and therefore a better understanding of the pathophysiological mechanisms underlying tissue fibrosis is sorely needed.
Amatucci, Aldo, Anderson, Daniel G, Brenner, David, Burkly, Linda C, Cameron, Thomas O, Cao, Lizhi, Dalkilic-Liddle, Isin, Duffield, Jeremy, Hamann, Stefan, Hossbach, Markus, Kauffman, Kevin J, Kisseleva, Tatiana, Koteliansky, Victor, Mir, Faryal F, Novobrantseva, Tatiana, Reynolds, Taylor, Vollmann, Elisabeth H   +16 more
core   +2 more sources

Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. [PDF]

, 2016
Excess collagen synthesis (fibrogenesis) in the liver plays a causal role in the progression of nonalcoholic fatty liver disease (NAFLD). Methods are needed to identify patients with more rapidly progressing disease and to demonstrate early response to ...
Angel, Thomas E, Beysen, Carine, Brenner, David A, Colangelo, Marc, Cui, Jeffrey, Decaris, Martin L, Emson, Claire L, Gatmaitan, Michelle, Hellerstein, Marc K, Hernandez, Carolyn, Lazaro, Len, Li, Kelvin W, Liu, Shanshan, Loomba, Rohit, Nyangau, Edna, Turner, Scott M, Wang, Yenny   +16 more
core   +1 more source