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Matrix metalloproteinases in liver injury, repair and fibrosis [PDF]
Matrix Biology, 2015 The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Sérgio Duarte +2 more
exaly +3 more sources
Empagliflozin-induced liver injury [PDF]
European Journal of Case Reports in Internal MedicineBackground: Drug-induced liver injury is an uncommon, idiosyncratic adverse reaction with heterogeneous clinical presentations, ranging from asymptomatic transaminase elevations to acute liver failure. Sodium-glucose cotransporter 2 inhibitors, widely prescribed for type 2 diabetes due to their glycaemic, cardiovascular, and renal benefits, are ...
Gonçalves, Hélder Diogo +6 more
openaire +3 more sources
Pathogen distribution and liver injury severity in children with community-acquired pneumonia complicated by liver injury in Suzhou, China [PDF]
Frontiers in PediatricsBackgroundLiver injury is a extrapulmonary complication of community-acquired pneumonia (CAP). However, limited data exist on the pathogen distribution and severity of liver injury in children with CAP-associated liver injury.
Kun Wang, ZhengJiayi Li, Fangfang Cheng
doaj +2 more sources
The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury [PDF]
, 2012 Recent evidence has demonstrated additional roles for the neuronal guidance protein receptor UNC5B outside the nervous system. Given the fact that ischemia reperfusion injury (IRI) of the liver is a common source of liver dysfunction and the role of ...
Granja, Tiago +7 more
core +16 more sources
Cell Death and Disease, 2022 Angiogenesis is a fundamental process underlying the occurrence, growth and metastasis of hepatocellular carcinoma (HCC), a prevalent tumour type with an extremely poor prognosis due to abundant vasculature.
Xuehong Wang +8 more
doaj +1 more source
Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis
Molecular Medicine, 2022 Background Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate acute pancreatitis.
Juan Xiao +4 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background Increasing evidence suggests a vital role of the pre-metastatic niche in the formation of distant metastasis of many cancers. However, how the pre-metastatic niche is formed and promotes pulmonary metastasis of hepatocellular carcinoma (HCC ...
Chong Zhang +8 more
doaj +1 more source
BMC Medical Genetics, 2020 Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. Current studies have shown that PNPLA3 (Patatin-like phospholipase domain containing 3) rs738409 G/C gene polymorphism is associated ...
Shan Tang +13 more
doaj +1 more source
Cell Death and Disease, 2022 The effect of glucosylceramide (GlcCer) reprogramming on liver cancer metastasis remains poorly understood. In this study, we demonstrated that the protein expression of GBA1, which catalyses the conversion of GlcCer to ceramide, was downregulated in ...
Zhidong Qiu +11 more
doaj +1 more source
Molecules, 2022 More than one hundred cannabinoids have been found in cannabis. Δ9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however, the mechanisms underlying THC-induced toxicity remain elusive.
Qianru Rao +10 more
doaj +1 more source