Results 1 to 10 of about 618,743 (313)

Empagliflozin-Induced Liver Injury. [PDF]

Eur J Case Rep Intern Med
Background: Drug-induced liver injury is an uncommon, idiosyncratic adverse reaction with heterogeneous clinical presentations, ranging from asymptomatic transaminase elevations to acute liver failure. Sodium-glucose cotransporter 2 inhibitors, widely prescribed for type 2 diabetes due to their glycaemic, cardiovascular, and renal benefits, are ...
Gonçalves HD, Parreira I, Vasconcelos-Teixeira S, Melício A, Dias M, Madeira Lopes J, Duarte L.   +6 more
europepmc   +3 more sources

S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression

Cell Death and Disease, 2022
Angiogenesis is a fundamental process underlying the occurrence, growth and metastasis of hepatocellular carcinoma (HCC), a prevalent tumour type with an extremely poor prognosis due to abundant vasculature.
Xuehong Wang, Zhidong Qiu, Wei Dong, Zebin Yang, Junnan Wang, Hailiang Xu, Tian Sun, Zhaoquan Huang, Junfei Jin   +8 more
doaj   +1 more source

Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis

Molecular Medicine, 2022
Background Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate acute pancreatitis.
Juan Xiao, Wenying Zeng, Pengcheng Zhang, Yuan Zhou, Qiangqiang Fang   +4 more
doaj   +1 more source

Pulmonary interleukin 1 beta/serum amyloid A3 axis promotes lung metastasis of hepatocellular carcinoma by facilitating the pre-metastatic niche formation

Journal of Experimental & Clinical Cancer Research, 2023
Background Increasing evidence suggests a vital role of the pre-metastatic niche in the formation of distant metastasis of many cancers. However, how the pre-metastatic niche is formed and promotes pulmonary metastasis of hepatocellular carcinoma (HCC ...
Chong Zhang, Qing Li, Qi Xu, Wei Dong, Chunmei Li, Bin Deng, Jiao Gong, Li-Zhen Zhang, Junfei Jin   +8 more
doaj   +1 more source

Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis

BMC Medical Genetics, 2020
Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. Current studies have shown that PNPLA3 (Patatin-like phospholipase domain containing 3) rs738409 G/C gene polymorphism is associated ...
Shan Tang, Jing Zhang, Ting Ting Mei, Hai Qing Guo, Xin Huan Wei, Wen Yan Zhang, Ya Li Liu, Shan Liang, Zuo Peng Fan, Li Xia Ma, Wei Lin, Yi Rong Liu, Li Xia Qiu, Hai Bin Yu   +13 more
doaj   +1 more source

GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway

Cell Death and Disease, 2022
The effect of glucosylceramide (GlcCer) reprogramming on liver cancer metastasis remains poorly understood. In this study, we demonstrated that the protein expression of GBA1, which catalyses the conversion of GlcCer to ceramide, was downregulated in ...
Zhidong Qiu, Xuehong Wang, Zebin Yang, Sicong Liao, Wei Dong, Tian Sun, Huixian Wu, Qinqin Zhang, Zhixiong Pan, Sin Man Lam, Guanghou Shui, Junfei Jin   +11 more
doaj   +1 more source

Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol

Molecules, 2022
More than one hundred cannabinoids have been found in cannabis. Δ9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however, the mechanisms underlying THC-induced toxicity remain elusive.
Qianru Rao, Ting Zhang, Manyun Dai, Bin Li, Qianlun Pu, Min Zhao, Yan Cheng, Dongmei Yan, Qi Zhao, Zhanxuan E. Wu, Fei Li   +10 more
doaj   +1 more source

Epidemiology of Liver Injuries [PDF]

Scandinavian Journal of Surgery, 2003
Background and Aims: The aim of this study was to investigate the epidemiology of liver injuries and to grade injuries according to the Organ Injury Scale in a population-based study in Stockholm County comprising 1.75 million inhabitants.
P, Talving, M, Beckman, T, Häggmark, L, Iselius   +3 more
openaire   +2 more sources

Metabolic Profile of C-Prenyl Coumarins Using Mass Spectrometry-Based Metabolomics

Molecules, 2021
C-prenyl coumarins (C-PYCs) are compounds with similar structures and various bioactivities, which are widely distributed in medicinal plants. Until now, the metabolic characterizations of C-PYCs and the relationship between metabolism and bioactivities ...
Yan Cheng, Xiaofang Ma, Qi Zhao, Chunyan Wang, Dongmei Yan, Fei Li   +5 more
doaj   +1 more source

Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma

World Journal of Surgical Oncology, 2022
Purpose Liver cancer is one of the most common tumors with the seventh-highest incidence and the third-highest mortality. Many studies have shown that small extracellular vesicles (sEVs) play an important role in liver cancer.
Wei Dong, Zeyu Xia, Zehua Chai, Zhidong Qiu, Xuehong Wang, Zebin Yang, Junnan Wang, Tingrui Zhang, Qinqin Zhang, Junfei Jin   +9 more
doaj   +1 more source