Results 31 to 40 of about 618,743 (313)

Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review

Frontiers in Pharmacology, 2022
Isoniazid (INH) and rifampicin (RFP) are the first-line medications for tuberculosis treatment, and liver injury is the major adverse effect. Natural medicinal ingredients provide distinct benefits in alleviating patients’ symptoms, lowering the liver ...
Xiuping Zhuang, Xiuping Zhuang, Li Li, Tianyi Liu, Rui Zhang, Peimin Yang, Xin Wang, Long Dai   +7 more
doaj   +1 more source

Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock : CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage [PDF]

, 2005
Exposure to bacterial superantigens such as staphylococcal enterotoxin B (SEB) leads to the induction of toxic shock syndrome which results in multiorgan failure, including liver damage.
Fisher, M., Andras K. Szakal, Ursula Gunthert, Robert J. McKallip, Szakal, A. K., Michael Fisher, Mitzi Nagarkatti, McKallip, R. J., Gunthert, U., Nagarkatti, P. S., Nagarkatti, M., Prakash S. Nagarkatti   +11 more
core   +1 more source

Drug induced liver injury – a 2023 update

, 2023
Drug-Induced Liver Injury (DILI) constitutes hepatic damage attributed to drug exposure. DILI may be categorized as hepatocellular, cholestatic or mixed and might also involve immune responses. When DILI occurs in dose-dependent manner, it is referred to
Isaac Thom Shawa, Rebecca Allison, Kermanizadeh, A., Gyan Tripathi, Wolfgang Moritz, Ali Kermanizadeh, Allison, R., Asha Guraka, Guraka, A., Shawa, I., Tripathi, G., Moritz, W.   +11 more
core   +1 more source

Liver Injury Patterns and Hepatic Toxicity among People Living with and without HIV and Attending Care in Urban Uganda

International Journal of Hepatology, 2023
Introduction. The evaluation of the patterns of liver injury, derived from liver chemistry panels, often may narrow on probable causes of the liver insult especially when coupled with clinical history, examination, and other diagnostic tests.
Clara Wekesa, Rosalind Parkes-Ratanshi, Gregory D. Kirk, Ponsiano Ocama   +3 more
doaj   +1 more source

Association between vessels that encapsulate tumour clusters vascular pattern and hepatocellular carcinoma recurrence following liver transplantation

Frontiers in Oncology, 2022
BackgroundVessels that encapsulate tumor clusters (VETC) is a novel vascular pattern seen on hepatocellular carcinoma (HCC) histology which has been shown to independently predict tumor recurrence and survival after liver resection.
Claude Dennis, David S. Prince, David S. Prince, Leila Moayed-Alaei, Devika Remash, Emily Carr-Boyd, David G. Bowen, David G. Bowen, Simone I. Strasser, Simone I. Strasser, Michael Crawford, Carlo Pulitano, Carlo Pulitano, James Kench, James Kench, Geoffrey W. McCaughan, Geoffrey W. McCaughan, Geoffrey W. McCaughan, Catriona McKenzie, Catriona McKenzie, Ken Liu, Ken Liu, Ken Liu   +22 more
doaj   +1 more source

Diagnosis of drug induced liver injury using a lymphocyte blast transformation test based on whole blood culture

, 1977
Twenty cases of suspected drug induced liver injury (16 cases of which satisfied the criteria for at least a query positive diagnosis as based on the Fourth Congress of "Drugs and the Liver" in Japan) were studied by the whole blood culture ...
Takata, Shinji
core   +1 more source

Hepatocyte-Derived Exosomes Reduce Hepatic Ischemia-Reperfusion (IR) Injury by Inhibiting Complement Activation

Frontiers in Bioscience-Landmark
Background: Exosomes are specialized secreted vesicles for intercellular communication and signaling pathways as specialized secreted vesicles.
Zhi Yang, Bin Deng, Tian Sun, Yongqin Wang, Wei Dong, Junfei Jin, Zhixiong Pan   +6 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Severe liver trauma among pediatric patients in the Japan Trauma Registry

World Journal of Pediatric Surgery, 2021
Background Limited information exists regarding the clinical characteristics, management practices, and outcomes of pediatric patients with liver injury in Japan.
Kiyohiro Oshima, Makoto Aoki, Toshikazu Abe, Shuichi Hagiwara, Daizoh Saitoh   +4 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source