Results 1 to 10 of about 233,130 (120)

Influence of Lavandula angustifolia on metabolic indicators and morphofunctional state of rat organs with a high-fat diet

open access: yesБіологія тварин, 2022
Herbal preparations recommended in the treatment protocols for metabolic disorders are highly effective and less toxic than chemically synthesized ones.
M. A. Lieshchova   +2 more
doaj   +1 more source

Health concerns of lambs fed cottonseed hulls combined with chitosan by examining the blood metabolic profile and histopathology of the kidney, liver, and rumen

open access: yesVeterinární Medicína, 2021
This study analysed the effect of cottonseed hulls and chitosan in diets for lambs by determining the blood metabolite profile, and the histopathology of the kidney, liver, and rumen.
T Silva Magalhaes   +11 more
doaj   +1 more source

The developmental gene Chordin is amplified and expressed in human cancers

open access: yesMolecular & Cellular Oncology, 2023
Chordin (CHRD) is a secreted protein important in early development, yet a role for CHRD in human disease has not been identified. In this study we investigated CHRD in cancer and normal adult tissues using the wealth of genome-wide data available in ...
Eric Sosa, Edward M. De Robertis
doaj   +1 more source

Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues

open access: yesMolecular Therapy: Methods & Clinical Development, 2023
Lipid nanoparticles (LNPs) for delivery of mRNA usually contain ionizable lipid/helper lipid/cholesterol/PEG-lipid in molar ratios of 50:10:38.5:1.5, respectively.
Nisha Chander   +4 more
doaj   +1 more source

Wharton’s Jelly Mesenchymal Stem Cell: Various Protocols for Isolation and Differentiation of Hepatocyte-Like Cells; Narrative Review [PDF]

open access: yesIranian Journal of Medical Sciences, 2019
There are several differentiation methods for mesenchymal stem cells (MSCs) into hepatocyte-like cell. Investigators reported various hepatic differentiation protocols such as modifying culturing conditions or using various growth factors/cytokines.
Negar Varaa   +3 more
doaj   +1 more source

Recent Advances in Models of Immune-Mediated Drug-Induced Liver Injury

open access: yesFrontiers in Toxicology, 2021
Hepatic inflammation is a key feature of a variety of liver diseases including drug-induced liver injury (DILI), orchestrated by the innate immune response (Kupffer cells, monocytes, neutrophils, dendritic cells) and the adaptive immune system (T cells ...
Farah Tasnim   +18 more
doaj   +1 more source

Features of iron homeostasis in patients with steatohepatitis of alcoholic and non-alcoholic etiology and its correlation with the intensity of oxidative stress and apoptosis

open access: yesJournal of Education, Health and Sport, 2021
Topicality. Comorbid course of alcoholic steatohepatitis (ASH) and non alcoholic steatohepatitis (NASH) with dysmetabolic iron overload syndrome (DIOS) is caused by the cascade of interload reactions, which may contribute to the progression of the ...
O. S. Khukhlina   +2 more
doaj   +1 more source

METABOLIC CHANGES IN HEPATOCYTES OF EXPERIMENTAL ANIMALS AFTER PROLONGED TREATMENT WITH SIMVASTATIN

open access: yesМедицинский вестник Юга России, 2013
Purpose: To analyse the metabolic changes in the liver cells of experimental animals after prolonged treatment with simvastatin.Materials and Methods: Our experiment was taken on 40 rates (males) which were divided on two groups: 1-st (control) – 20 ...
Z. I. Mikashinovich   +2 more
doaj   +1 more source

TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

open access: yesCell Reports, 2021
Summary: Chronic injury to hepatocytes results in inflammation, steatohepatitis, fibrosis, and nonalcoholic fatty liver disease (NAFLD). The tetraspanin TM4SF5 is implicated in fibrosis and cancer.
Eunmi Kim   +10 more
doaj   +1 more source

Mechanisms of transcriptional control of glucose metabolism in hepatocytes

open access: yesСахарный диабет, 2016
The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes ...
Konstantin Y. Kulebyakin   +3 more
doaj   +1 more source

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