Results 1 to 10 of about 3,202,592 (310)

Analysis of the effect of hashimoto's thyroiditis and insulin resistance on ovarian volume in patients with polycystic ovary syndrome

BMC Women's Health, 2023
Objective In this study, patients were divided into two groups. Patients with polycystic ovary syndrome (PCOS) and patients with polycystic ovary syndrome + Hashimoto's Thyroid (PCOS + HT).
Gülcan Gencer, Aliye Nigar Serin, Kerem Gencer   +2 more
doaj   +1 more source

Sustained expression of hemopexin in an animal model of sickle cell anemia

Blood Vessels, Thrombosis & Hemostasis
: Sickle cell disease is a condition characterized by vaso-occlusive episodes and sustained hemolysis, leading to a chronic inflammatory state. Several studies have shown that the release of heme to the extracellular space due to hemolysis contributes to
Franciele De Lima, Carla Roberta Peachazepi De Moraes, Ivanio Teixeira Borba-Junior, Heloísa Balan Assalin, Mario José Abdalla Saad, Fernando Ferreira Costa, Erich V. De Paula   +6 more
doaj   +1 more source

Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats

Cardiovascular Diabetology, 2008
Despite the marked advances in research on insulin resistance (IR) in humans and animal models of insulin resistance, the mechanisms underlying high salt-induced insulin resistance remain unclear.
Shehata Marlene F
doaj   +1 more source

Changing Clinical Characteristics according to Insulin Resistance and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients in Korea [PDF]

Diabetes & Metabolism Journal, 2015
BackgroundThe role of increased insulin resistance in the pathogenesis of type 2 diabetes has been emphasized in Asian populations. Thus, we evaluated the proportion of insulin resistance and the insulin secretory capacity in patients with early phase ...
Jang Won Son, Cheol-Young Park, Sungrae Kim, Han-Kyu Lee, Yil-Seob Lee,   +5 more
doaj   +1 more source

Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites

Biomedicines, 2022
The concept of insulin resistance has been around since a few decades after the discovery of insulin itself. To allude to the classic Charles Dicken’s novel published 62 years before the discovery of insulin, in some ways, this is the best of times, as ...
Elizabeth M. Rhea, William A. Banks, Jacob Raber   +2 more
doaj   +1 more source

Rab4b controls hepatic glucose production during fasting through glycophagy

Nature Communications
Hepatic glucose production, essential for maintaining glycemia, is often altered in metabolic-associated fatty liver and glycogen storage diseases. Therefore, understanding the mechanisms that regulate the glucose production by hepatocyte is pivotal ...
Marion Dussot, Lucie Le Parc, Sihame Sabbane, Alycia Zedda, Abderrahman Chafik, Alexandre Gallerand, Karine Dumas, Stéphanie Bonnafous, Yun Kwon, Sandra Lacas-Gervais, Charlotte Hinault Boyer, Giulia Chinetti, Sophie Giorgetti-Peraldi, Philippe Gual, Stoyan Ivanov, Anja Zeigerer, Jean-François Tanti, Mireille Cormont, Jerome Gilleron   +18 more
doaj   +1 more source

Effects of a Circuit Training Program on Myokine Levels in Insulin-Resistant Women: A Randomised Controlled Trial

Journal of Diabetes Research
Conclusion: The circuit training program implemented in women newly diagnosed with insulin resistance significantly increased their serum IL-6 and not their IL-10, FGF21, and irisin levels.
Joanna Karolkiewicz, Monika Krzywicka, Monika Szulińska, Katarzyna Musialik, Dominka Musiałowska, Jacek Zieliński, Agnieszka Bilska, Marzena Ratajczak   +7 more
doaj   +1 more source

Insulin dynamics in young women with polycystic ovary syndrome and normal glucose tolerance across categories of body mass index.

PLoS ONE, 2014
BackgroundEvidence favours insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps primary, defects in polycystic ovary syndrome (PCOS). The aim of the present study was to evaluate insulin metabolism in young women with PCOS but
Melania Manco, Lidia Castagneto-Gissey, Eugenio Arrighi, Annamaria Carnicelli, Claudia Brufani, Rosa Luciano, Geltrude Mingrone   +6 more
doaj   +1 more source

Research progress on the role of FGF21 in insulin resistance

Frontiers in Endocrinology
The elevated global prevalence of metabolic syndrome and type 2 diabetes mellitus (T2DM) has led to a dramatic increase in patients with insulin resistance.
Haixin Zhang, Rongyu Zhu, Quanhao Sun, Likun Du   +3 more
doaj   +1 more source

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

eLife, 2018
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue.
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James   +23 more
doaj   +1 more source