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Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System
BiomedicinesHyperinsulinemia refers to an elevated level of circulating insulin (80 and 100 µU/mL), often leading to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ghassan Bkaily +2 more
exaly +4 more sources
Acute effects of euglycemic‐hyperinsulinemia on myocardial contractility in male mice
Physiological Reports, 2022 Type 2 diabetes and obesity are associated with increased risk of cardiovascular disease, including heart failure. A hallmark of these dysmetabolic states is hyperinsulinemia and decreased cardiac reserve.
Satya Murthy Tadinada +4 more
doaj +2 more sources
Chronic hyperinsulinemia promotes human hepatocyte senescence
Molecular Metabolism, 2022 Objective: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging ...
Ritesh K. Baboota +10 more
doaj +2 more sources
Prevalence of hyperinsulinemia and its association with measures of adiposity and body composition in 16-25-year-old adolescents and young adults in Mumbai [PDF]
BMC Endocrine DisordersBackground Hyperinsulinemia and insulin resistance (IR) are early indicators of metabolic dysfunction that often precede the development of Type 2 Diabetes (T2D).
Panchali Moitra +5 more
doaj +2 more sources
Frontiers in Clinical Diabetes and Healthcare, 2023 ObjectiveThis study aimed to investigate the clinical implications of fasting serum insulin (FINS) levels in subjects with type 2 diabetes who were receiving insulin therapy.MethodsA total of 1,553 subjects with type 2 diabetes [774 subjects who had ...
Lingli Zhou +8 more
doaj +1 more source
Hyperinsulinemia Associated Depression
Clinical Medicine Insights: Endocrinology and Diabetes, 2022 Hyperinsulinemia promotes fat accumulation, causing obesity. Being an inflammatory state, obesity can induce further inflammation and is a risk factor for HPA (hypothalamic pituitary axis) dysregulation through hypercortisolism-related hyperglycemia.
Haider Sarwar +12 more
doaj +1 more source
Cardiovascular diseases in youth patients with glucose metabolism impairment
Arterial Hypertension, 2021 Glucose metabolism disorders in adolescent patients have a diverse background. The most common cause is type 1 diabetes. Persistently elevated blood glucose initiates many processes that lead to blood vessel and nerve damage.
Aleksandra Pilśniak +2 more
doaj +1 more source
Hepatology Communications, EarlyView., 2022 Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk +6 more
wiley +1 more source
Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance [PDF]
, 2021 Hyperinsulinemia is commonly viewed as a compensatory response to insulin resistance, yet studies have demonstrated that chronically elevated insulin may also drive insulin resistance. The molecular mechanisms underpinning this potentially cyclic process
Hussein, Bahira +29 more
core +1 more source
Valproate-Related Hyperinsulinemia
Pediatric Neurology Briefs, 2006 Changes in insulin metabolism during treatment with valproate (VPA) were investigated in a study of 51 patients receiving monotherapy (31 male and 20 female) and 45 healthy controls at University of Oulu, and Hospital of Children and Adolescents ...
J Gordon Millichap
doaj +1 more source