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Hyperinsulinemia Associated Depression
Clinical Medicine Insights: Endocrinology and Diabetes, 2022 Hyperinsulinemia promotes fat accumulation, causing obesity. Being an inflammatory state, obesity can induce further inflammation and is a risk factor for HPA (hypothalamic pituitary axis) dysregulation through hypercortisolism-related hyperglycemia.
Haider Sarwar +12 more
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Prevalence of hyperinsulinemia and its association with measures of adiposity and body composition in 16-25-year-old adolescents and young adults in Mumbai [PDF]
BMC Endocrine DisordersBackground Hyperinsulinemia and insulin resistance (IR) are early indicators of metabolic dysfunction that often precede the development of Type 2 Diabetes (T2D).
Panchali Moitra +5 more
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Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System [PDF]
BiomedicinesHyperinsulinemia refers to an elevated level of circulating insulin (80 and 100 µU/mL), often leading to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ghassan Bkaily +3 more
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Frontiers in Clinical Diabetes and Healthcare, 2023 ObjectiveThis study aimed to investigate the clinical implications of fasting serum insulin (FINS) levels in subjects with type 2 diabetes who were receiving insulin therapy.MethodsA total of 1,553 subjects with type 2 diabetes [774 subjects who had ...
Lingli Zhou +8 more
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Chronic hyperinsulinemia promotes human hepatocyte senescence
Molecular Metabolism, 2022 Objective: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging ...
Ritesh K. Baboota +10 more
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Acute effects of euglycemic‐hyperinsulinemia on myocardial contractility in male mice
Physiological Reports, 2022 Type 2 diabetes and obesity are associated with increased risk of cardiovascular disease, including heart failure. A hallmark of these dysmetabolic states is hyperinsulinemia and decreased cardiac reserve.
Satya Murthy Tadinada +4 more
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Cardiovascular diseases in youth patients with glucose metabolism impairment
Arterial Hypertension, 2021 Glucose metabolism disorders in adolescent patients have a diverse background. The most common cause is type 1 diabetes. Persistently elevated blood glucose initiates many processes that lead to blood vessel and nerve damage.
Aleksandra Pilśniak +2 more
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Hyperinsulinemia in Obesity, Inflammation, and Cancer [PDF]
Diabetes & Metabolism Journal, 2021 The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia. Studies are beginning to elucidate the cause-effect relationships between hyperinsulinemia and numerous consequences ...
Anni M.Y. Zhang +3 more
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Valproate-Related Hyperinsulinemia
Pediatric Neurology Briefs, 2006 Changes in insulin metabolism during treatment with valproate (VPA) were investigated in a study of 51 patients receiving monotherapy (31 male and 20 female) and 45 healthy controls at University of Oulu, and Hospital of Children and Adolescents ...
J Gordon Millichap
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Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors
Open Veterinary Journal, 2023 Background: Sodium-Glucose CoTransporter-2 [SGLT2] inhibitors, the -flozin group of drugs, which block glucose reuptake in the renal proximal tubule, are being increasingly used off-label to treat horses with refractory hyperinsulinemia. After two years
Eleanor M. Kellon, Kathleen M. Gustafson
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