Results 31 to 40 of about 82,926 (310)

Hyperinsulinemia adversely affects lung structure and function

open access: yesAmerican Journal of Physiology - Lung Cellular and Molecular Physiology, 2016
Anurag Agrawal   +2 more
exaly   +2 more sources

Acute effects of euglycemic‐hyperinsulinemia on myocardial contractility in male mice

open access: yesPhysiological Reports, 2022
Type 2 diabetes and obesity are associated with increased risk of cardiovascular disease, including heart failure. A hallmark of these dysmetabolic states is hyperinsulinemia and decreased cardiac reserve.
Satya Murthy Tadinada   +4 more
doaj   +1 more source

Hyperinsulinemia: an early biomarker of metabolic dysfunction

open access: yesFrontiers in Clinical Diabetes and Healthcare, 2023
Introduction Hyperinsulinemia in the absence of impaired glucose tolerance and normal HbA1c is considered indicative of pre-diabetes. Very few Indian studies have focused on hyperinsulinemia particularly in young adults.
R. Vaidya   +10 more
semanticscholar   +1 more source

Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study

open access: yesEBioMedicine, 2021
Background It is commonly accepted that in obesity free fatty acids (FFA) cause insulin resistance and hyperglycemia, which drives hyperinsulinemia. However, hyperinsulinemia is observed in subjects with normoglycaemia and thus the paradigm above should ...
E. Fryk   +12 more
semanticscholar   +1 more source

Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models

open access: yesNature Communications, 2021
Accumulating evidence indicates that obesity with its associated metabolic dysregulation, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer.
Manasi Das   +10 more
semanticscholar   +1 more source

Cardiovascular diseases in youth patients with glucose metabolism impairment

open access: yesArterial Hypertension, 2021
Glucose metabolism disorders in adolescent patients have a diverse background. The most common cause is type 1 diabetes. Persistently elevated blood glucose initiates many processes that lead to blood vessel and nerve damage.
Aleksandra Pilśniak   +2 more
doaj   +1 more source

Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19

open access: yesDiabetes, 2021
Aging, obesity, and diabetes are major risk factors for the severe progression and outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 [COVID-19]), but the underlying mechanism is not yet fully ...
Jihoon Shin   +6 more
semanticscholar   +1 more source

ROLE OF HYPERINSULINEMIA AND INSULIN RESISTANCE IN HYPERTENSION: METABOLIC SYNDROME REVISITED

open access: yesCanadian Journal of Cardiology, 2020
Hyperinsulinemia and insulin resistance were proposed more than 30 years ago to be important contributors to elevated blood pressure (BP) associated with obesity and the metabolic syndrome, also called syndrome X.
Alexandre A. da Silva   +5 more
semanticscholar   +1 more source

Noninvasive tests for nonalcoholic fatty liver disease in a multi‐ethnic population: The HELIUS study

open access: yesHepatology Communications, EarlyView., 2022
Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk   +6 more
wiley   +1 more source

What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

open access: yesDiabetes, 2021
We hypothesize that basal hyperinsulinemia is synergistically mediated by an interplay between increased oxidative stress and excess lipid in the form of reactive oxygen species (ROS) and long-chain acyl-CoA esters (LC-CoA).
B. Corkey, J. Deeney, M. Merrins
semanticscholar   +1 more source

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