Results 51 to 60 of about 62,541 (232)

Influence of insulin resistance on renal function in patients with abdominal obesity.

Medičnì Perspektivi, 2015
The purpose of the study - to assess the role of insulin resistance in the development of initial manifestations of renal disease in patients with abdominal obesity.
T. O. Pertseva, M. K. Rokutova
doaj   +1 more source

Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

MedComm, 2021
Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic atypical PKC (aPKC)
Mini P. Sajan, Barbara C. Hansen, Mildred Acevedo‐Duncan, Mark S. Kindy, Denise R. Cooper, Robert V. Farese   +5 more
doaj   +1 more source

Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress

Equine Veterinary Journal, EarlyView.
Abstract Background Lamellar endoplasmic reticulum (ER) stress occurs in hyperinsulinemia‐associated and sepsis‐related laminitis. Adiponectin is associated with reduced laminitis risk and inhibits ER stress in other species. Objectives To induce ER stress in ex vivo equine lamellar cells using pharmacological agents.
Marine A. Barnabé, Jonathan Elliott, Nicola J. Menzies‐Gow, Simon R. Bailey, Nicholas J. Bamford, Yu‐Mei Chang, Matthew C. Gage   +6 more
wiley   +1 more source

The impact of hyperinsulinemia on short-term prognosis in patients with hypertriglyceridemia-induced acute pancreatitis

Frontiers in Endocrinology
PurposeThe short-term prognosis of hyperinsulinemia in patients with hyperlipidemia resulting in acute pancreatitis remains uncertain, so this research explores the correlation between them.Material and methodsThis study retrospectively analyzed patients
Mengjun Wang, Mengjun Wang, Mengjun Wang, Lei Zheng, Long Qian, Maoqi Xu   +5 more
doaj   +1 more source

Prevalence of insulin dysregulation in a sport horse population as determined by traditional and stall‐side testing

Equine Veterinary Journal, EarlyView.
Abstract Background The prevalence of insulin dysregulation (ID) has not been investigated in sport horses. Stall‐side insulin assays offer convenience but need further validation. Objectives To determine the prevalence of and risk factors for ID in a sport horse population using an oral sugar test (OST) and assess agreement between stall‐side and ...
Kimberly L. Hallowell, Caitlyn R. Horne, Cary S. Miller, Sara R. Tufts, Katarzyna Dembek, Kim R. Love, Andrew W. van Eps, Lauren V. Schnabel   +7 more
wiley   +1 more source

Pancreatic α‐cell dysfunction associated with equine insulin dysregulation

Equine Veterinary Journal, EarlyView.
Abstract Background Insulin dysregulation (ID) in horses is characterised by insulin resistance and exaggerated insulin responses, yet the underlying endocrine mechanisms remain incompletely understood. In humans, α‐cell dysfunction characterised by exaggerated glucagon secretion contributes to metabolic disease; however, the role of pancreatic α‐cell ...
Sanna Lindåse, Emma Strage, Josefin Söder, Johan Bröjer   +3 more
wiley   +1 more source

Metabolic and Endocrine Insights in Donkeys

Animals
Donkey medicine is gaining attention due to their increased use as companion animals, in shows, asinotherapy, etc. The increasing demand and unique aspects call for specialized care, requiring new information (physiology, infectious disorders ...
Francisco J. Mendoza, Ramiro E. Toribio, Alejandro Perez-Ecija   +2 more
doaj   +1 more source

Comparable attenuation of sympathetic nervous system activity in obese subjects with normal glucose tolerance, impaired glucose tolerance and treatment naïve type 2 diabetes following equivalent weight loss

Frontiers in Physiology, 2016
Background and Purpose: Elevated sympathetic nervous system (SNS) activity is a characteristic of obesity and type 2 diabetes (T2D) that contributes to target organ damage and cardiovascular risk.
Nora E. Straznicky, Mariee T. Grima, Carolina I. Sari, Elisabeth A. Lambert, Sarah E. Phillips, Nina Eikelis, Justin A. Mariani, Daisuke Kobayashi, Dagmara Anna Hering, John B Dixon, Gavin W Lambert   +10 more
doaj   +1 more source

Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release

Cell Reports, 2021
Summary: Hepatic lipid accumulation in obesity correlates with the severity of hyperinsulinemia and systemic insulin resistance. Obesity-induced hepatocellular lipid accumulation results in hepatocyte depolarization.
Caroline E. Geisler, Susma Ghimire, Chelsea Hepler, Kendra E. Miller, Stephanie M. Bruggink, Kyle P. Kentch, Mark R. Higgins, Christopher T. Banek, Jun Yoshino, Samuel Klein, Benjamin J. Renquist   +10 more
doaj   +1 more source

Hyperinsulinemia Promotes Esophageal Cancer Development in a Surgically-Induced Duodeno-Esophageal Reflux Murine Model [PDF]

, 2018
Hyperinsulinemia could have a role in the growing incidence of esophageal adenocarcinoma (EAC) and its pre-cancerous lesion, Barrett's Esophagus, a possible consequence of Gastro-Esophageal Reflux Disease.
FRANCIA, SIMONA, Derek LeRoith, Arcidiacono, Diletta, Alberti, Alfredo, Federico Fabris, Fassan, Matteo, Cassaro, Mauro, Mauro Cassaro, Emily Gallagher, LeRoith, Derek, Realdon, Stefano, Arben Dedja, Giacometti, Cinzia, Massimo Rugge, Cinzia Giacometti, NUCCI, DANIELE, FABRIS, FEDERICO, Daniele Nucci, Alfredo Alberti, Rugge, Massimo, Matteo Fassan, Stefano Realdon, Alice Zaramella, Simona Francia, Dedja, Arben, ZARAMELLA, ALICE, Gallagher, Emily J, Diletta Arcidiacono   +27 more
core   +1 more source