Results 71 to 80 of about 49,307 (224)

Metabolic Phenotype Predicts Biochemical Response to Inositol Supplementation in Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To evaluate the effect of inositol supplementation on biochemical hyperandrogenism in women with polycystic ovary syndrome (PCOS) and to explore whether metabolic phenotype modifies the endocrine response. Design Systematic review and meta‐analysis of randomized controlled trials conducted in accordance with PRISMA guidelines ...
Daniele Tienforti, Gennaro Puocci, Claudia Venditti, Valentina Gizzi, Carlo Pisanò, Elisa Cocci, Elisabetta Perfetto, Francesco D'Alessandro, Luca Spagnolo, Marco Giorgio Baroni, Arcangelo Barbonetti   +10 more
wiley   +1 more source

Sex‐specific differences in the prevalence of intermediate hyperglycaemia states: A systematic review and meta‐analysis

Diabetic Medicine, EarlyView.
There are sex‐specific disparities in the prevalence of different isolated intermediate hyperglycaemic states, which, in the context of clinical guidance to use FPG or HbA1c for identification, may contribute to underdiagnosis and undertreatment in primary care and introduce ascertainment bias into research and policy. Abstract Aims To evaluate the sex‐
Louise Cooper, Ian Porter, Claire Meek, Simon J. Griffin, Amy Ahern   +4 more
wiley   +1 more source

Current treatment options for acanthosis nigricans

Clinical, Cosmetic and Investigational Dermatology, 2018
Nupur U Patel,1 Catherine Roach,1 Hossein Alinia,1 William W Huang,1 Steven R Feldman1–3 1Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC, 2Department of Pathology, Wake ...
Patel NU, Roach C, Alinia H, Huang WW, Feldman SR   +4 more
doaj  

Mechanism of the mitogenic influence of hyperinsulinemia [PDF]

Diabetology & Metabolic Syndrome, 2011
Either endogenous or exogenous hyperinsulinemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras protein. Increased availability of farnesylated Ras at the plasma membrane enhances mitogenic responsiveness of cells to various growth factors, thus contributing ...
openaire   +3 more sources

Enriched Metabolic Phenotyping Refines Phenotypic Resolution of Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Data‐driven clustering studies of type 2 diabetes (T2D) based on limited routine clinical variables have reproducibly described major metabolic subgroups, including severe insulin‐deficient diabetes (SIDD), severe insulin‐resistant diabetes (SIRD), mild obesity‐related diabetes and mild age‐related diabetes.
Min Wang, Yang Ou, Heng Su, Bing Zhang, Ben Niu, Anwar Ahmed, Guoqiang Xing   +6 more
wiley   +1 more source

Dose–Response Effect of Glucagon on Glucose, Beta‐Cell Secretion and Metabolism in Healthy Individuals

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Glucagon is a key regulator of glucose and energy metabolism, yet the dose–response effects of glucagon on markers of metabolism in humans are not fully characterised. We investigated the dose‐dependent effects of glucagon on glucose metabolism, β‐cell secretion and markers of hepatic metabolism in healthy adults.
Sophie Betty Brock, Nina Lerberg Hansen, Elvar Már Sturlaugsson Jóhönnuson, Sasha Alexandra Sampson Kjeldsen, Nicolai J. Wewer Albrechtsen   +4 more
wiley   +1 more source

Hyperinsulinemia [PDF]

, 2020
  +5 more sources

Diabetes and cortical thickness in ethnically diverse cognitively normal older adults

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Mechanisms linking type 2 diabetes mellitus (T2DM) with dementia are poorly understood. We examined T2DM associations with cortical thickness and hippocampal volume in ethnoracially diverse, cognitively unimpaired older adults.
Amaryllis A. Tsiknia, Victoria R. Tennant, Noelle Lee, Brandon J. Hall, Raul Vintimilla, Nalini Hazra, Deydeep Kothapalli, Arthur W. Toga, Sid E. O'Bryant, Rajesh R. Nandy, Alexandra L. Clark, Melissa Petersen, Kristine Yaffe, Meredith N. Braskie, for the HABS‐HD study team   +14 more
doaj   +1 more source

Short‐Term Combined Treatment With Tirzepatide and Metformin for Overweight/Obese Chinese Women With Polycystic Ovary Syndrome: A Prospective, Open‐Label, Randomised Controlled Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This study aimed to assess the effects of low‐dose tirzepatide combined with metformin (COM) versus metformin (MET) monotherapy in overweight/obese women with polycystic ovary syndrome (PCOS). Materials and Methods Sixty overweight/obese women with PCOS were randomised to the MET group (1000 mg twice daily [BID]) or the COM group (MET ...
Zhuoran Yang, Yuxin Xu, Hu Du, Wenya Liu, Haiyan Chen, Dongfang Liu, Lili Zhang, Cong Wang   +7 more
wiley   +1 more source

Continuous glucose monitoring–guided management of capivasertib‐associated hyperglycemia: A case series of three patients

Journal of Diabetes Investigation, EarlyView.
Continuous glucose monitoring (CGM) visualized cyclic glycemic fluctuations associated with the 4‐days‐on/3‐days‐off capivasertib schedule. Compared with off‐treatment days, dosing days showed higher mean sensor glucose, greater coefficient of variation (CV), more time above 250 mg/dL, and lower time in range (TIR; 70–180 mg/dL).
Hiroki Okumura, Ryotaro Bouchi, Kenju Ando, Hannah Mizuno, Hirofumi Sugimoto, Kotaro Umamoto, Noriko Kodani, Noriko Ihana‐Sugiyama, Kazuo Izumi, Mitsuru Ohsugi, Kohjiro Ueki, Akihiko Shimomura, Chikako Shimizu, Akiyo Tanabe   +13 more
wiley   +1 more source