Results 61 to 70 of about 82,926 (310)
Biomedicines, 2021 Acute porphyria attacks are associated with the strong up-regulation of hepatic heme synthesis and over-production of neurotoxic heme precursors. First-line therapy is based on carbohydrate loading.
Isabel Solares +11 more
doaj +1 more source
International Journal of Molecular SciencesThe worldwide incidence of prediabetes/type 2 has continued to rise the last 40 years. In the same period, the mean daily energy intake has increased, and the quality of food has significantly changed.
Joseph A. M. J. L. Janssen
semanticscholar +1 more source
Adipocyte, 2020 Hyperinsulinemia is the hallmark of the development of insulin resistance and precedes the diagnosis of type 2 diabetes. Here we evaluated the effects of prolonged exposure (≥4 days) to high insulin doses (150 nM) in vitro in two adipose cell types ...
A. Rossi +7 more
doaj +1 more source
Does Oxidative Stress Cause Insulin Resistance in Women with Polycystic Ovary Syndrome?
مجله دانشکده پزشکی اصفهان, 2020 Background: Polycystic ovary syndrome (PCOS), with a prevalence of 4-12 percent, is the most common endocrine-metabolic disorder in reproductive age of women.
Farideh Zafari-Zangeneh
doaj +1 more source
Role of lipotoxicity in achieving glycemic control in patients with diabetes type 2 and obesity
Медицинский совет, 2013 Obesity increases the risk of diabetes mellitus type 2 due to the development of insulin resistance. Therapy for diabetes mellitus type 2 is limited by a relatively small amount of knowledge on the mechanisms of insulin resistance, despite the ...
А. S. Ametov +4 more
doaj +1 more source
Medicina, 2021 Background and Objectives: Hyperinsulinemia and insulin resistance are not synonymous; if the risk of developing insulin resistance in adolescents is monitored, they do not necessarily have hyperinsulinemia.
Igor Lukic +5 more
doaj +1 more source
Prolonged hyperinsulinemia affects metabolic signal transduction markers in a tissue specific manner
, 2016 Insulin dysregulation is common in horses although the mechanisms of metabolic dysfunction are poorly understood. We hypothesized that insulin signaling in striated (cardiac and skeletal) muscle and lamellae may be mediated through different receptors as
Lacombe, V.A. +4 more
core +1 more source
Медицинский совет, 2015 Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age associated with hyperandrogenism, anovulatory infertility and metabolic disorders.
G. E. Chernukha +2 more
doaj +1 more source
Aging Reduces Insulin Clearance in Mice
Frontiers in Endocrinology, 2021 Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in elderly. Since insulin secretion and clearance decline with age, hyperinsulinemia seems to be maintained, primarily, due to a decrease in the insulin clearance.
Carine Marmentini +8 more
doaj +1 more source
Cardiac effect of acute hyperinsulinemia and chronic fat feeding
, 2022 Within cardiomyocytes, the negative effects summarised by changing insulin signaling, increasing substrate accumulation and inflexibility in metabolism shifting.
A-Kasem, Aya
core