Results 81 to 90 of about 82,926 (310)

Baseline Body Mass Index Category and Incident Treated Hypertension in Australian Men: A Linked Prospective Cohort Study Using PBS/MBS Data

Chronic Diseases and Translational Medicine, EarlyView.
Kaplan–Meier hypertension‐free survival by baseline body mass index category, primary adult cohort (men aged ≥ 18 years, n = 12,742). Time since baseline in years is plotted on the horizontal axis and the probability of remaining free of treated hypertension is plotted on the vertical axis. Numbers at risk are shown beneath the plot.
Ebenezer Afrifa‐Yamoah
wiley   +1 more source

A systematic review using the Theoretical Domains Framework to identify barriers and facilitators to the adoption of prescribing guidelines

International Journal of Pharmacy Practice, EarlyView., 2020
Abstract Objectives Evidence‐based guidelines have the potential to reduce variation and increase prescribing quality. Identifying the key determinants to their uptake, using a theory‐based approach, may assist in the design of successful interventions to increase their adoption into practice.
Paulina Paksaite, Margaret Watson, Joel Crosskey, Eni Sula, Celine West   +4 more
wiley   +1 more source

The Potential for Ketogenic Diets to Control Glucotoxicity, Hyperinsulinemia, and Insulin Resistance to Improve Fertility in Women with Polycystic Ovary Syndrome

Clinical and Experimental Obstetrics & Gynecology
Objective: This review aims to summarize the association between insulin resistance (IR) and symptoms of Polycystic Ovary Syndrome (PCOS) while explaining how nutritional interventions, specifically ketogenic diets, help manage PCOS.
Leticia Ramírez-Martínez, Cecilia Palafox-Gómez, Leonardo M. Porchia, Esther López-Bayghen   +3 more
doaj   +1 more source

Metformin Can Attenuate Beta-Cell Hypersecretion—Implications for Treatment of Children with Obesity

Metabolites, 2023
In children with obesity, insulin hypersecretion is proposed to precede insulin resistance. We investigated if metformin could be used to attenuate insulin secretion from palmitate-treated isolated islets and its implication for children with obesity ...
Quan Wen, Rasmus Stenlid, Azazul Islam Chowdhury, Iris Ciba, Banu Aydin, Sara Y. Cerenius, Hannes Manell, Anders Forslund, Peter Bergsten   +8 more
doaj   +1 more source

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

Diabetes, 2019
Although insulin resistance consistently occurs with type 1 diabetes, its predominant driver is uncertain. We therefore determined the relative contributions of hyperglycemia and iatrogenic hyperinsulinemia to insulin resistance using hyperinsulinemic ...
J. Gregory, T. Smith, J. Slaughter, H. R. Mason, Curtis C. Hughey, Marta S. Smith, Balamurugan Kandasamy, S. Greeley, L. Philipson, R. Naylor, L. Letourneau, N. Abumrad, A. Cherrington, D. Moore   +13 more
semanticscholar   +1 more source

Short‐term clinical responses in horses and ponies treated with canagliflozin: A clinical field study

Equine Veterinary Journal, EarlyView.
Abstract Background Treatment with the sodium‐glucose co‐transporter 2 (SGLT2) inhibitor canagliflozin in insulin dysregulated (ID) horses has shown promising results in randomised clinical trials. Larger field studies are needed to further evaluate treatment responses and potential adverse effects under real‐world conditions.
Moa Hällbom, Sanna Truelsen Lindåse, Monika Wartel, Johan Bröjer   +3 more
wiley   +1 more source

Effects of T2DM on cancer progression: pivotal precipitating factors and underlying mechanisms

Frontiers in Endocrinology
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder affecting people worldwide. It is characterized by several key features, including hyperinsulinemia, hyperglycemia, hyperlipidemia, and dysbiosis.
Yu-Yuan Zhang, Yu-Yuan Zhang, Yong-Jiang Li, Yong-Jiang Li, Chun-Dong Xue, Chun-Dong Xue, Shen Li, Zheng-Nan Gao, Kai-Rong Qin, Kai-Rong Qin   +9 more
doaj   +1 more source

Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress

Equine Veterinary Journal, EarlyView.
Abstract Background Lamellar endoplasmic reticulum (ER) stress occurs in hyperinsulinemia‐associated and sepsis‐related laminitis. Adiponectin is associated with reduced laminitis risk and inhibits ER stress in other species. Objectives To induce ER stress in ex vivo equine lamellar cells using pharmacological agents.
Marine A. Barnabé, Jonathan Elliott, Nicola J. Menzies‐Gow, Simon R. Bailey, Nicholas J. Bamford, Yu‐Mei Chang, Matthew C. Gage   +6 more
wiley   +1 more source

Influence of insulin resistance on renal function in patients with abdominal obesity.

Medičnì Perspektivi, 2015
The purpose of the study - to assess the role of insulin resistance in the development of initial manifestations of renal disease in patients with abdominal obesity.
T. O. Pertseva, M. K. Rokutova
doaj   +1 more source

Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

MedComm, 2021
Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic atypical PKC (aPKC)
Mini P. Sajan, Barbara C. Hansen, Mildred Acevedo‐Duncan, Mark S. Kindy, Denise R. Cooper, Robert V. Farese   +5 more
doaj   +1 more source