Results 81 to 90 of about 62,541 (232)

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Insulin resistance has closer correlation with the occurrence of metabolic dysfunction associated steatotic liver disease diagnosed by liver biopsy

Frontiers in Medicine
ObjectiveTo explore any correlation between serum urate (SU) level or insulin resistance (IR) and metabolic dysfunction associated steatotic liver disease (MASLD) in patients with metabolic syndrome (MS).MethodsData from all MASLD patients, diagnosed by ...
Weihua Cao, Tingting Jiang, Wen Deng, Shiyu Wang, Xinxin Li, Ziyu Zhang, Lu Zhang, Yao Lu, Min Chang, Ruyu Liu, Shuling Wu, Ge Shen, Yuanjiao Gao, Hongxiao Hao, Xiaoxue Chen, Leiping Hu, Mengjiao Xu, Wei Yi, Yao Xie, Yao Xie, Minghui Li, Minghui Li   +21 more
doaj   +1 more source

Macrophages, low-grade inflammation, insulin resistance and hyperinsulinemia

, 2022
Metabolic derangement with poor glycemic control accompanying overweight and obesity is associated with chronic low-grade inflammation and hyperinsulinemia.
Henkel-Oberländer, Janin (Prof. Dr.), Klauder, Julia (Dr.), Püschel, Gerhard (Prof. Dr. med.)   +2 more
core   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source

Dietary Flavonoid Hyperoside Ameliorates High‐Fat Diet‐Induced Type 2 Diabetes Mellitus by Enhancing Brown Adipose Tissue Thermogenesis, White Adipose Tissue Browning, and Gut Microbiota Remodeling

Phytotherapy Research, EarlyView.
Hyperoside ameliorates metabolic dysfunction in high‐fat diet‐induced type 2 diabetic mice, accompanied by enhanced brown adipose tissue thermogenic activity, inguinal white adipose tissue browning‐related changes, reduced M1 macrophage polarization, and gut microbiota remodeling.
WeiFeng Cai, WenXin Zeng, Yu Luo, Qiang Liu, CuiPing Jiang, YanKui Yi, JieYu Chen, ChunYan Shen   +7 more
wiley   +1 more source

Current treatment options for acanthosis nigricans

Clinical, Cosmetic and Investigational Dermatology, 2018
Nupur U Patel,1 Catherine Roach,1 Hossein Alinia,1 William W Huang,1 Steven R Feldman1–3 1Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC, 2Department of Pathology, Wake ...
Patel NU, Roach C, Alinia H, Huang WW, Feldman SR   +4 more
doaj  

Influencing Factors Associated With Infantile Hemangioma: A Case–Control Study Among Chinese Pediatric Populations

The Journal of Dermatology, EarlyView.
ABSTRACT Infantile hemangioma (IH) is the most common benign vascular tumor of infancy. While its epidemiology is well‐documented in Caucasian populations, large‐scale systematic studies regarding clinical characteristics and risk factors in the Chinese population remain limited.
Xinyu Liu, Dan Song, Liang Wang, Changfeng Wang, Lei Guo   +4 more
wiley   +1 more source

Effect of hyperinsulinemia and very-low-calorie diet on interstitial cytokine levels in subcutaneous adipose tissue of obese women.

, 2009
International audienceAim: Type II diabetes and obesity are associated with an enhanced release of a number of adipocytokines. Hyperinsulinemia - frequently present in type II diabetes and obesity - might be one of the drivers of the enhanced production ...
Langin, Dominique, Hejnová, Jindra, Bajzová, Magda, Vrzalova, Jindra, Kovacikova, Michaela, Polák, Jan, Klimcakova, Eva, Rossmeislova, Lenka, Siklova-Vitkova, Michaela, Kovácová, Zuzana, Hnevkovska, Zuzana, Stich, Vladimir   +11 more
core   +1 more source

Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

, 2022
Background Hyperinsulinemia is independently associated with increased risk and mortality of pancreatic cancer. We recently reported that genetically reduced insulin production resulted in ~ 50% suppression of pancreatic intraepithelial ...
Yang, Jenny C. C., Chhuor, Justin, Zhang, Anni, Daly, Brian, Dou, Yan, Wang, Su, Zhao, Yiwei B., Hu, Xiaoke, Li, Hong, Johnson, James D., Chu, Ken H., de Winter, Twan, Flibotte, Stephane, Kopp, Janel, Ruiter, Titine, Rideout, Elizabeth J., Schaeffer, David F., Brian F. Daly, Ken H. Chu, Anni M. Y. Zhang, Titine Ruiter, Twan J. J. de Winter, Stephane Flibotte, Elizabeth J. Rideout, Xiaoke Hu, Jenny C. C. Yang, David F. Schaeffer, James D. Johnson, Justin Chhuor, Janel L. Kopp, Hong Li, Su Wang, Yan Dou, Yiwei Bernie Zhao   +33 more
core   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source