Results 101 to 110 of about 49,307 (224)
Obesity Reviews, Volume 27, Issue 7, July 2026.ABSTRACT In a scenario with increasing cases of obesity and diabetes worldwide, branched‐chain amino acids (BCAA) metabolism has become an important factor in the understanding of these pathologies. More recently, its chronic high plasma levels have been postulated, alongside glucose, inflammatory factors, and other molecules, as an important ...
Bernardo Starling‐Soares +4 more
wiley +1 more source
The Relationship Between 2D:4D Digit Ratio and Polycystic Ovary Syndrome: A Systematic Review
American Journal of Human Biology, Volume 38, Issue 6, June 2026.ABSTRACT Objectives This systematic review aimed to synthesize current evidence on the association between 2D:4D ratios and PCOS. Methods A comprehensive literature search was performed in PubMed, Web of Science, Scopus, and Cochrane Library databases between May and June 2025. Two independent researchers conducted study screening, data extraction, and
Tuba Güner Emül, Emine Kaplan Serin
wiley +1 more source
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Activation of the voltage gated K+ channel KV7.1 leads to hyperpolarization shift of cell membranes. In a thorough SAR study eight positions of the lead compound (R)‐L3 were modified. (R)‐configuration, the indolylmethyl moiety in 3‐position and the 2‐fluorophenyl moiety in 5‐position appeared to be essential for high KV7.1 activation, whereas an OH ...
Florian Roßner +3 more
wiley +1 more source
Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 85-99, June 2026.Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves +8 more
wiley +1 more source
Clinical Cardiology, Volume 49, Issue 6, June 2026.An integrative conceptual framework linking the five principal domains addressed in this review. Beginning at the molecular level, loss‐of‐function mutations in KCNQ1 and KCNH2 reduce outward repolarizing currents (IKs and IKr), while gain‐of‐function SCN5A mutations augment late inward sodium current (INa), establishing the genetic substrate for ...
Mojtaba Farjam +2 more
wiley +1 more source
Streptozotocin induced hyperglycemia in the axolotl
Developmental Dynamics, Volume 255, Issue 6, Page 567-584, June 2026.Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen +2 more
wiley +1 more source
eFood, Volume 7, Issue 3, June 2026.Upcycling agricultural by‐products into functional resources, this study demonstrates that Cucumis melo var. makuwa leaf (CML) extract exerts a marked weight‐independent improvement of hepatic steatosis. CML extract markedly alleviates lipid accumulation, oxidative stress, and inflammation in MASLD, highlighting its potent hepatoprotective and ...
Ji Young Hwang +12 more
wiley +1 more source
Effects and Mechanisms of Stevioside on Metabolic Dysfunction‐Associated Steatotic Liver Disease
Food Science &Nutrition, Volume 14, Issue 6, June 2026.SV has the potential to prevent or treat MASLD by improving hepatic lipid metabolism, enhancing anti‐inflammatory and antioxidant capacity, and attenuating hepatic fibrosis. ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects more than 30% of adults globally and has emerged as a significant public health concern ...
Kangjun Li +6 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.This cross‐sectional study investigated the relationships between ultra‐processed food (UPF) consumption, night eating symptoms, and gastrointestinal (GI)‐specific anxiety in 205 women with polycystic ovary syndrome (PCOS). UPF consumption was associated with GI‐specific anxiety in unadjusted analyses but was not an independent predictor after ...
Emine Merve Ekici +3 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Background and Aims This study aimed to evaluate the impact of the Transitional Care Model (TCM) on quality of life (QoL) and caregiver burden among family caregivers of patients with multiple chronic conditions (MCCs). Methods A two‐arm, single‐blind (data analysts blinded) randomized clinical trial was conducted from April to November 2024 ...
Maryam karami +3 more
wiley +1 more source