Results 101 to 110 of about 62,541 (232)

Obesity-related cognitive impairment: The role of endothelial dysfunction

Neurobiology of Disease, 2019
Obesity is a global pandemic associated with macro- and microvascular endothelial dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk factor for the development of cognitive impairment. In this review, we present
Joy Jones Buie, Luke S. Watson, Crystal J. Smith, Catrina Sims-Robinson   +3 more
doaj   +1 more source

Hyperinsulinemia

, 2014
: Concurrent with the epidemic of childhood obesity (17% of adolescents), an unprecedented world-wide increase in the prevalence of several adiposity-related complications (including fatty liver disease (hepatic steatosis), type 2 diabetes and early ...

core  

Analysis of Risk Factors for Normal Glucose Tolerance-Hyperinsulinemia [PDF]

, 2018
The aim of this paper is to study the prevalence of individuals with normal glucose tolerance-hyperinsulinemia in Nanshan of Shenzhen, determine the cut point values of normal glucose tolerance-hyperinsulinemia, and investigate the risk factors for it ...
Li, MD, Lian, Nie, MD, Lei, Ye, MD, Xiaoman, Yu, MD, Ming, Ai, MD, Wei, Zhong, MD, Zhibiao, Chi, MD, Lianxiang   +6 more
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Nephroprotective Effects of the Dual GCGR/GLP‐1R Agonist Survodutide in Hypertension‐Accelerated Diabetic Kidney Disease

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Survodutide is a novel long‐acting dual glucagon (GCGR)/glucagon‐like peptide‐1 (GLP‐1R) receptor agonist currently in phase‐3 clinical development for the treatment of people living with obesity and metabolic dysfunction‐associated steatohepatitis.
Alexander Hamilton, Louise Thisted, Maria Ougaard, Max Hahn, Kasper Andersen, Johanna Perens, Robert Augustin, Besnik Bajrami, Wolfgang Rist, Michael Christensen, Henrik H. Hansen, Thomas Klein   +11 more
wiley   +1 more source

Dietary Cholest-4-en-3-one, a Cholesterol Metabolite of Gut Microbiota, Alleviates Hyperlipidemia, Hepatic Cholesterol Accumulation, and Hyperinsulinemia in Obese, Diabetic db/db Mice

Metabolites
Previous studies have shown that dietary cholest-4-en-3-one (4-cholestenone, 4-STN) exerts anti-obesity and lipid-lowering effects in mice. However, its underlying mechanisms are not fully understood.
Mina Higuchi, Mai Okumura, Sarasa Mitsuta, Bungo Shirouchi   +3 more
doaj   +1 more source

Nonuniform regional sympathetic nerve responses to hyperinsulinemia in rats

, 1993
The insulin hypothesis of hypertension proposes that hyperinsulinemia increases sympathetic nerve activity (SNA) and raises arterial pressure. The goals of this study were 1) to determine if hyperinsulinemia produces regionally uniform or nonuniform ...
T. W. Balon, D. A. Morgan, B. H. Ginsberg, A. L. Mark   +3 more
core   +1 more source

Circulating miR‐342‐3p as a biomarker for diagnosing gestational diabetes mellitus and predicting adverse perinatal outcomes: A retrospective cohort study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims This study evaluated the clinical utility of circulating miR‐342‐3p for diagnosing gestational diabetes mellitus (GDM) and predicting adverse perinatal outcomes (APOs). Methods A retrospective cohort of 261 GDM women (the GDM group) and 261 propensity score‐matched healthy controls (the Normal group) was analyzed.
Kangjun Yu, Sanqiang Niu, Hai Liang
wiley   +1 more source

Insulin Resistance/Hyperinsulinemia as an Independent Risk Factor That Has Been Overlooked for Too Long

Biomedicines
Unfortunately, cardiovascular diseases and cancers are still the leading causes of death in developed and developing countries despite the considerable progress made in the prevention and treatment of diseases. Maybe we missed something?
Serafino Fazio, Flora Affuso, Arturo Cesaro, Loredana Tibullo, Valeria Fazio, Paolo Calabrò   +5 more
doaj   +1 more source

Association of atherogenic index of plasma with gestational diabetes mellitus and birth weight outcomes, and the mediating role of blood glucose

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims This study aimed to examine the associations of maternal first‐trimester atherogenic index of plasma (AIP) with gestational diabetes mellitus (GDM) and birth weight outcomes, and the mediating role of second‐trimester blood glucose. Methods This prospective cohort study included 5,706 pregnant women without pre‐existing diabetes or other ...
Doudou Zhao, Yanfang Song, Nan Li, Yu Zhang, Yiting Li, Kangxin Wang, Yang Mi, Lei Shang, Pengfei Qu   +8 more
wiley   +1 more source

The low fasting serum C‐peptide level was associated with reduced sural nerve action potential amplitudes: A cross‐sectional study of Japanese type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
Low fasting serum C‐peptide levels were independently associated with abnormal sural nerve action potential amplitude measured by DPNCheck® in patients with type 2 diabetes. Fasting serum C‐peptide may serve as a clinically relevant marker for diabetic polyneuropathy. ABSTRACT Aims/Introduction The association between the fasting serum C‐peptide levels
Taichi Muramatsu, Kaori Inoue‐Yamamoto, Daisuke Yamamuro, Akifumi Kushiyama   +3 more
wiley   +1 more source