Results 1 to 10 of about 2,026,798 (359)
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*
Endocrine Reviews, 1997 Andrea Dunaif
exaly +2 more sources
European Journal of Endocrinology, 1999 The pathogenesis of type 2 diabetes is characterized by insulin resistance, primarily in skeletal muscle, fat and liver, and a relative failure of the pancreatic b-cell (1, 2). Considerable controversy surrounds the issue of which of these deficiencies is the primary cause of diabetes.
openaire +2 more sources
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Signal Transduction and Targeted Therapy, 2022 The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition.
Mengwei Li +5 more
semanticscholar +1 more source
Insulin Resistance: From Mechanisms to Therapeutic Strategies
Diabetes & Metabolism Journal, 2021 Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin.
Shin-Hae Lee, Shi-Young Park, C. Choi
semanticscholar +1 more source
Adipose tissue and insulin resistance in obese.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021 Currently, obesity has become a global health issue and is referred to as an epidemic. Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin resistance.
Bulbul Ahmed, R. Sultana, M. Greene
semanticscholar +1 more source
Mechanisms of Insulin Action and Insulin Resistance.
Physiological Reviews, 2018 The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. In the intervening century, some discoveries have matured, coalescing into solid and fertile ground for ...
Max C. Petersen, G. Shulman
semanticscholar +1 more source
Association between insulin resistance and the development of cardiovascular disease
Cardiovascular Diabetology, 2018 For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance.
V. Ormazábal +5 more
semanticscholar +1 more source
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Nature Reviews Neurology, 2018 Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and type 2 diabetes mellitus (T2DM), two of the most pressing epidemics of our time.
S. Arnold +11 more
semanticscholar +1 more source
Lancet Neurology, 2020 Insulin is a peptide secreted by the pancreas and plays an important role in the regulation of glucose metabolism in peripheral tissues. Although the role of insulin in the periphery is well understood, less is known about its multifactorial role in the ...
D. Kellar, S. Craft
semanticscholar +1 more source
Cell Metabolism, 2009 Summary Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance.
C. Newgard +20 more
semanticscholar +1 more source