Screening and Identification of Disaccharides with Insulin Mimetic Activity against L6 Cells [PDF]
, 2014 Insulin mimetics are considered as prospective anti-diabetic agents, and the disaccharide, neohesperidose, has been found to show insulin mimetic activity against L6 cells.
Hishiki, Ryogo +3 more
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Diabetology & Metabolic Syndrome, 2018 Background In humans and animal models, excessive intake of dietary fat, fructose and cholesterol has been linked to the development of non-alcoholic fatty liver disease (NAFLD). However, the individual roles of the dietary components remain unclear.
Victoria Svop Jensen +7 more
doaj +1 more source
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Signal Transduction and Targeted Therapy, 2022 The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition.
Mengwei Li +5 more
semanticscholar +1 more source
The effects of peripheral and central high insulin on brain insulin signaling and amyloid-β in young and old APP/PS1 mice [PDF]
, 2016 Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in vivo experiments are needed to validate these relationships ...
Caesar, Emily E +9 more
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Insulin infusion sets associated with adverse events: strategies for improved diabetes education
Frontiers in Medicine, 2023 IntroductionInsulin Infusion Sets (IIS) play a crucial role in ensuring the safe delivery of insulin through a Continuous Subcutaneous Insulin Infusion (CSII) for individuals with Type 1 Diabetes (T1D). Recent advancements in therapy have highlighted the
Ana Lucia Domingues Neves +12 more
doaj +1 more source
Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents [PDF]
, 2018 OBJECTIVE: To compare prevalence of insulin resistance between perinatally HIV-infected (PHIV+) and perinatally HIV-exposed, but uninfected adolescents (PHEU), determine incidence of and contributory factors to new and resolved cases of insulin ...
Dimeglio, Linda A. +13 more
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Journal of Diabetes Research, 2018 Introduction. This study aimed at evaluating the efficacy and safety of dapagliflozin in patients with type 2 diabetes (T2D) who also received metformin in clinical practice in Italy. Methods.
Alessandro Scorsone +8 more
doaj +1 more source
Role of some serum biomarkers in the early detection of diabetic cardiomyopathy
Future Science OA, 2021 Aim: To assess the role of serum biomarkers in early prediction of diabetic cardiomyopathy. Materials and methods: The participants were three groups of Type 2 diabetes mellitus (DM) patients having diastolic dysfunction (DM-DD), systolic dysfunction (DM-
Amany H Abdelrahman +9 more
doaj +1 more source
Serum IgG2 levels are specifically associated with whole-body insulin-mediated glucose disposal in non-diabetic offspring of type 2 diabetic individuals. a cross-sectional study [PDF]
, 2018 .Preclinical studies suggested that IgG2c isotype may specifically impair skeletal muscle insulin sensitivity in mice. In this study we investigated the association between serum levels of the four IgG subclasses and insulin sensitivity in non-diabetic
Andreozzi, F +11 more
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Insulin Resistance: From Mechanisms to Therapeutic Strategies
Diabetes & Metabolism Journal, 2021 Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin.
Shin-Hae Lee, Shi-Young Park, C. Choi
semanticscholar +1 more source