Results 91 to 100 of about 62,541 (232)

Diabetes and cortical thickness in ethnically diverse cognitively normal older adults

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Mechanisms linking type 2 diabetes mellitus (T2DM) with dementia are poorly understood. We examined T2DM associations with cortical thickness and hippocampal volume in ethnoracially diverse, cognitively unimpaired older adults.
Amaryllis A. Tsiknia, Victoria R. Tennant, Noelle Lee, Brandon J. Hall, Raul Vintimilla, Nalini Hazra, Deydeep Kothapalli, Arthur W. Toga, Sid E. O'Bryant, Rajesh R. Nandy, Alexandra L. Clark, Melissa Petersen, Kristine Yaffe, Meredith N. Braskie, for the HABS‐HD study team   +14 more
doaj   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

The Bidirectional Association Between MASLD and Male Hypogonadism: An Updated Meta‐Analysis

Andrology, EarlyView.
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) and male hypogonadism are increasingly prevalent, metabolically interrelated conditions. Testosterone (T) deficiency has been implicated in hepatic lipid dysregulation, insulin resistance, and visceral adiposity, whereas MASLD may impair the hypothalamic–pituitary ...
Giorgia Spaggiari, Leonardo Dalla Valentina, Cristina Felicani, Filippo Gabrielli, Simonetta Lugari, Giovanni Corona, Paolo Ventura, Manuela Simoni, Fabio Nascimbeni, Daniele Santi   +9 more
wiley   +1 more source

Evidence That Chromium Modulates Cellular Cholesterol Homeostasis and ABCA1 Functionality Impaired by Hyperinsulinemia—Brief Report

, 2011
Objective— Trivalent chromium (Cr 3+ ) is an essential micronutrient. Findings since the 1950s suggest that Cr 3+ might benefit cholesterol homeostasis.
Whitney Sealls, Brent A. Penque, Jeffrey S. Elmendorf, Elmendorf, Jeffrey S., Sealls, Whitney, Penque, Brent A.   +5 more
core   +1 more source

Retrospective Evaluation of a New Danish National Guideline: Impact on Neonatal Hypoglycemia and Breastfeeding

Acta Paediatrica, EarlyView.
ABSTRACT Aim This study evaluates the impact of the most recent Danish national guideline for the management of neonatal hypoglycemia on neonate nutrition at discharge and the incidence of neonatal hypoglycaemia within the first 24 h postpartum. The updated guideline introduced a 50% reduction in early feeding volume to support exclusive breastfeeding ...
Mariuma Samim, Najma Abdihakim Mohamud, Huda Al‐Hage, Lars Bender, Rasa Cipliene   +4 more
wiley   +1 more source

Male LEW.1WR1 Rats Develop Metabolic Dysfunction, Steatohepatitis, and Liver Damage

Endocrines
Most patients with non-alcoholic steatohepatitis (NASH) have insulin resistance, and there is a near-universal association between NASH and insulin resistance.
Quiana C. Wilkerson-Vidal, Madushika M. Wimalarathne, Emily C. Hunt, Luis Mercado, Moses Adaji David, Christopher R. Apperson, Alan Smiley, Sharifa Tahirah Love-Rutledge, Bernhard W. G. Vogler   +8 more
doaj   +1 more source

Antenatal Corticosteroids in Gestational Diabetes: A Systematic Review of Glycemic Response and Management Strategies

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Antenatal corticosteroids (ACS) promote foetal lung maturation in pregnancies at risk of preterm birth; however, in gestational diabetes mellitus (GDM), they can exacerbate maternal glycemia and contribute to adverse neonatal outcomes. Clinical guidelines offer limited direction on optimal treatment adjustment.
Alexandra Katz, Aidan Shulkin, Samantha Jacobson, Chella Price, Michael A. Tsoukas, Isabella Albanese, Agnieszka Majdan, Jill Pancer, Ariane Godbout, Kaberi Dasgupta, Anne‐Sophie Brazeau, Tricia Peters   +11 more
wiley   +1 more source

Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation

Journal of Ovarian Research, 2011
Background Metformin, an oral biguanide traditionally used for the treatment of type 2 diabetes, is widely used for the management of polycystic ovary syndrome (PCOS)-related anovulation.
Sabatini Mary E, Guo Lankai, Lynch Maureen P, Doyle Joseph O, Lee HoJoon, Rueda Bo R, Styer Aaron K   +6 more
doaj   +1 more source

Hypothalamic hyperinsulinemia and obesity: role of adrenal glucocorticoids

, 1983
The effects of adrenalectomy on the obesity and hyperinsulinemia induced by ventromedial hypothalamic (VMH) lesions were studied in female rats. Plasma insulin and glucose levels were assayed after a 4-h fast and 17 min after the initiation of a meal (6
A. R. Banta, B. K. Bruce, G. N. Tharel, B. M. King, L. A. Frohman   +4 more
core   +1 more source

Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer

Biomedicines
Despite all the progress made by science in the prevention and treatment of cardiovascular diseases and cancers, these are still the main reasons for hospitalizations and death in the Western world.
Serafino Fazio, Paolo Bellavite, Flora Affuso   +2 more
doaj   +1 more source