Results 121 to 130 of about 82,926 (310)

Hyperinsulinemia augments endothelin‐1 protein expression and impairs vasodilation of human skeletal muscle arterioles

Physiological Reports, 2016
Hyperinsulinemia is a hallmark of insulin resistance‐associated metabolic disorders. Under physiological conditions, insulin maintains a balance between nitric oxide (NO) and, the potent vasoconstrictor, endothelin‐1 (ET‐1). We tested the hypothesis that
Abeer M. Mahmoud, Mary R. Szczurek, Brian K. Blackburn, Jacob T Mey, Zhenlong Chen, Austin T. Robinson, J. Bian, T. Unterman, R. Minshall, Michael D. Brown, J. Kirwan, S. Phillips, J. Haus   +12 more
semanticscholar   +1 more source

Influencing Factors Associated With Infantile Hemangioma: A Case–Control Study Among Chinese Pediatric Populations

The Journal of Dermatology, EarlyView.
ABSTRACT Infantile hemangioma (IH) is the most common benign vascular tumor of infancy. While its epidemiology is well‐documented in Caucasian populations, large‐scale systematic studies regarding clinical characteristics and risk factors in the Chinese population remain limited.
Xinyu Liu, Dan Song, Liang Wang, Changfeng Wang, Lei Guo   +4 more
wiley   +1 more source

Insulin resistance has closer correlation with the occurrence of metabolic dysfunction associated steatotic liver disease diagnosed by liver biopsy

Frontiers in Medicine
ObjectiveTo explore any correlation between serum urate (SU) level or insulin resistance (IR) and metabolic dysfunction associated steatotic liver disease (MASLD) in patients with metabolic syndrome (MS).MethodsData from all MASLD patients, diagnosed by ...
Weihua Cao, Tingting Jiang, Wen Deng, Shiyu Wang, Xinxin Li, Ziyu Zhang, Lu Zhang, Yao Lu, Min Chang, Ruyu Liu, Shuling Wu, Ge Shen, Yuanjiao Gao, Hongxiao Hao, Xiaoxue Chen, Leiping Hu, Mengjiao Xu, Wei Yi, Yao Xie, Yao Xie, Minghui Li, Minghui Li   +21 more
doaj   +1 more source

Impact of hyperinsulinemia on myosin heavy chain gene regulation

, 1999
The purpose of this study was to determine whether hyperinsulinemia alters myosin heavy chain (MHC) gene expression in human skeletal muscle. A biopsy from the vastus lateralis was obtained in young, lean [age 24.6 ± 1.0 (SE) yr, body fat 11.9 ± 1.9 ...
G. Lynis Dohm, Joseph A. Houmard, D. Sean O’Neill, Donghai Zheng, Matthew S. Hickey   +4 more
core   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Hyperinsulinemia

, 2014
: Concurrent with the epidemic of childhood obesity (17% of adolescents), an unprecedented world-wide increase in the prevalence of several adiposity-related complications (including fatty liver disease (hepatic steatosis), type 2 diabetes and early ...

core  

Hyperinsulinemia and Cardiovascular Disease in Elderly Men

, 1998
—Hyperinsulinemia has been associated with cardiovascular disease (CVD), but whether this relation is independent of other CVD risk factors is uncertain. Most studies have focused on coronary heart disease (CHD), but few have included peripheral vascular
Richard Arakaki, Katsuhiko Yano, Cecil M. Burchfiel, Dan S. Sharp, J. David Curb, Beatriz L. Rodriguez, Robert D. Abbott   +6 more
core   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Current treatment options for acanthosis nigricans

Clinical, Cosmetic and Investigational Dermatology, 2018
Nupur U Patel,1 Catherine Roach,1 Hossein Alinia,1 William W Huang,1 Steven R Feldman1–3 1Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC, 2Department of Pathology, Wake ...
Patel NU, Roach C, Alinia H, Huang WW, Feldman SR   +4 more
doaj  

Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance

Journal of Biological Chemistry, 2015
Background: Enhanced hepatic expression of the fatty acid transporter Cd36 correlates with liver fat accumulation, hepatosteatosis, insulin resistance, and hyperinsulinemia.
Pär Steneberg, A. Sykaras, Fredrik Backlund, Jurate Straseviçiene, I. Söderström, H. Edlund   +5 more
semanticscholar   +1 more source