Results 21 to 30 of about 82,926 (310)

Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases

open access: yesJournal of Clinical Medicine, 2022
Metabolic derangement with poor glycemic control accompanying overweight and obesity is associated with chronic low-grade inflammation and hyperinsulinemia.
G. Püschel, J. Klauder, J. Henkel
semanticscholar   +2 more sources

Prevalence of hyperinsulinemia and its association with measures of adiposity and body composition in 16-25-year-old adolescents and young adults in Mumbai [PDF]

open access: yesBMC Endocrine Disorders
Background Hyperinsulinemia and insulin resistance (IR) are early indicators of metabolic dysfunction that often precede the development of Type 2 Diabetes (T2D).
Panchali Moitra   +5 more
doaj   +2 more sources

Association between hyperinsulinemia and increased risk of cancer death in nonobese and obese people: A population‐based observational study

open access: yesInternational Journal of Cancer, 2017
Obesity, metabolic syndrome and type 2 diabetes are associated with cancer‐related mortality. We assessed whether hyperinsulinemia is a risk factor for cancer death in nonobese people without diabetes.
Tetsuro Tsujimoto
exaly   +2 more sources

Metabolic syndrome, hyperinsulinemia, and cancer [PDF]

open access: yesThe American Journal of Clinical Nutrition, 2007
The term metabolic syndrome describes the association between obesity, insulin resistance, and the risk of several prominent chronic diseases, including cancer. The causal link between many of these components remains unexplained, however. What is clear are the events that precede the development of the syndrome itself.
Isabel R, Hsu   +3 more
openaire   +3 more sources

Hyperinsulinemia: A unifying theory of chronic disease? [PDF]

open access: yes, 2015
Globally, there is an increasing prevalence of non-communicable diseases. The morbidity and mortality from these conditions confer a greater economic societal burden.
C. Crofts
semanticscholar   +2 more sources

Equine hyperinsulinemia: investigation of the enteroinsular axis during insulin dysregulation. [PDF]

open access: yesAmerican Journal of Physiology. Endocrinology and Metabolism, 2016
Compared with some other species, insulin dysregulation in equids is poorly understood. However, hyperinsulinemia causes laminitis, a significant and often lethal disease affecting the pedal bone/hoof wall attachment site.
M. D. de Laat, J. McGree, M. Sillence
semanticscholar   +3 more sources

Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders

open access: yesNature Communications, 2018
Hyperinsulinemia is the earliest symptom of insulin resistance (IR), but a causal relationship between the two remains to be established. Here we show that a protein kinase D2 (PRKD2) nonsense mutation (K410X) in two rhesus monkeys with extreme ...
Yao Xiao   +23 more
semanticscholar   +2 more sources

Molecular mechanisms of hyperinsulinemia in obesity [PDF]

open access: yes, 2023
Treballs Finals de Grau de Nutrició Humana i Dietètica, Facultat de Farmàcia i Ciències de l'Alimentació, Campus de l'Alimentació de Torribera, Universitat de Barcelona. Curs: 2022-2023.
Bayod Jaime, Laura
core   +6 more sources

Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer

open access: yesInternational Journal of Molecular Sciences, 2021
For many years, the dogma has been that insulin resistance precedes the development of hyperinsulinemia. However, recent data suggest a reverse order and place hyperinsulinemia mechanistically upstream of insulin resistance.
J. Janssen
semanticscholar   +1 more source

The clinical implications of fasting serum insulin levels in patients with insulin-treated type 2 diabetes: a cross-sectional survey

open access: yesFrontiers in Clinical Diabetes and Healthcare, 2023
ObjectiveThis study aimed to investigate the clinical implications of fasting serum insulin (FINS) levels in subjects with type 2 diabetes who were receiving insulin therapy.MethodsA total of 1,553 subjects with type 2 diabetes [774 subjects who had ...
Lingli Zhou   +8 more
doaj   +1 more source

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