Results 21 to 30 of about 49,307 (224)

Valproate Induced Obesity and Polycystic Ovaries

Pediatric Neurology Briefs, 1996
Fourteen (64%) of 22 women receiving valproate monotherapy for epilepsy had polycystic ovaries, hyperandrogenism, or both, in a study at the Departments of Neurology, Obstetrics and Gynecology, and Pediatrics, University of Oulu, Finland.
J Gordon Millichap
doaj   +1 more source

MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions

Cells, 2022
The dysregulation of microRNAs has recently been associated with cancer development and progression in pancreatic ductal adenocarcinoma (PDAC) and cystic pancreatic lesions.
Christian Prinz, Leonard Fehring, Robin Frese   +2 more
doaj   +1 more source

High Prevalence of Insulin Resistance in Asymptomatic Patients with Acute Intermittent Porphyria and Liver-Targeted Insulin as a Novel Therapeutic Approach

Biomedicines, 2021
Acute porphyria attacks are associated with the strong up-regulation of hepatic heme synthesis and over-production of neurotoxic heme precursors. First-line therapy is based on carbohydrate loading.
Isabel Solares, Laura Izquierdo-Sánchez, Montserrat Morales-Conejo, Daniel Jericó, Francisco Javier Castelbón, Karol Marcela Córdoba, Ana Sampedro, Carlos Lumbreras, María Jesús Moreno-Aliaga, Rafael Enríquez de Salamanca, Pedro Berraondo, Antonio Fontanellas   +11 more
doaj   +1 more source

In vitro characterization of the effects of chronic insulin stimulation in mouse 3T3-L1 and human SGBS adipocytes

Adipocyte, 2020
Hyperinsulinemia is the hallmark of the development of insulin resistance and precedes the diagnosis of type 2 diabetes. Here we evaluated the effects of prolonged exposure (≥4 days) to high insulin doses (150 nM) in vitro in two adipose cell types ...
A. Rossi, M. Eid, J. Dodgson, G. Davies, B. Musial, M. Wabitsch, C. Church, D.C. Hornigold   +7 more
doaj   +1 more source

Does Oxidative Stress Cause Insulin Resistance in Women with Polycystic Ovary Syndrome?

مجله دانشکده پزشکی اصفهان, 2020
Background: Polycystic ovary syndrome (PCOS), with a prevalence of 4-12 percent, is the most common endocrine-metabolic disorder in reproductive age of women.
Farideh Zafari-Zangeneh
doaj   +1 more source

Role of lipotoxicity in achieving glycemic control in patients with diabetes type 2 and obesity

Медицинский совет, 2013
Obesity increases the risk of diabetes mellitus type 2 due to the development of insulin resistance. Therapy for diabetes mellitus type 2 is limited by a relatively small amount of knowledge on the mechanisms of insulin resistance, despite the ...
А. S. Ametov, N. A. Chernikova, F. R. Abdulkadirova, R. A. Pokrovskaya, O. Y. Alferova   +4 more
doaj   +1 more source

Risk Assessment and Determination of Factors That Cause the Development of Hyperinsulinemia in School-Age Adolescents

Medicina, 2021
Background and Objectives: Hyperinsulinemia and insulin resistance are not synonymous; if the risk of developing insulin resistance in adolescents is monitored, they do not necessarily have hyperinsulinemia.
Igor Lukic, Nikola Savic, Maja Simic, Nevena Rankovic, Dragica Rankovic, Ljubomir Lazic   +5 more
doaj   +1 more source

New prospects in the management of functional reproductive disorders associated with polycystic ovary syndrome

Медицинский совет, 2015
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age associated with hyperandrogenism, anovulatory infertility and metabolic disorders.
G. E. Chernukha, E. K. Kaprina, A. A. Naidukova   +2 more
doaj   +1 more source

Aging Reduces Insulin Clearance in Mice

Frontiers in Endocrinology, 2021
Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in elderly. Since insulin secretion and clearance decline with age, hyperinsulinemia seems to be maintained, primarily, due to a decrease in the insulin clearance.
Carine Marmentini, Gabriela M. Soares, Gabriela A. Bronczek, Silvano Piovan, Cecília E. Mareze-Costa, Everardo M. Carneiro, Antonio C. Boschero, Mirian A. Kurauti, Mirian A. Kurauti   +8 more
doaj   +1 more source

The effects of hyperinsulinemia on cochlear functions

Noise and Health, 2020
Hyperinsulinemia is the most common metabolic change associated with cochleovestibular diseases.We aimed to investigate the auditory functions in hyperinsulinemic individuals.A total of 164 patients were included in this case-control study. While 76 patients with insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] of ≥2.5 ...
Arzu Or Koca, Hüseyin Samet Koca, Cüneyd Anil   +2 more
openaire   +3 more sources