Results 11 to 20 of about 82,926 (310)
Chronic hyperinsulinemia promotes human hepatocyte senescence
Molecular Metabolism, 2022 Objective: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging ...
Ritesh K. Baboota +10 more
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Hyperinsulinemia in Obesity, Inflammation, and Cancer [PDF]
Diabetes & Metabolism Journal, 2021 The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia.
Anni M.Y. Zhang +3 more
doaj +7 more sources
Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System
BiomedicinesHyperinsulinemia refers to an elevated level of circulating insulin (80 and 100 µU/mL), often leading to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ghassan Bkaily, Danielle Jacques
exaly +4 more sources
Mild Suppression of Hyperinsulinemia to Treat Obesity and Insulin Resistance
Trends in Endocrinology and Metabolism, 2018 Insulin plays roles in lipid uptake, lipolysis, and lipogenesis, in addition to controlling blood glucose levels. Excessive circulating insulin is associated with adipose tissue expansion and obesity, yet a causal role for hyperinsulinemia in the ...
Melissa Page, James D Johnson
exaly +3 more sources
Definitions, 2020 For Educational Purposes Only Seek appropriate professional assistance for all serious health problems. Handout prepared by Tree of Light Publishing P.O. Box 911239, St.
semanticscholar +5 more sources
Cell Metabolism, 2023 The rising pancreatic cancer incidence due to obesity and type 2 diabetes is closely tied to hyperinsulinemia, an independent cancer risk factor. Previous studies demonstrated reducing insulin production suppressed pancreatic intraepithelial neoplasia ...
Janel Kopp
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Hyperinsulinemia Associated Depression
Clinical Medicine Insights: Endocrinology and Diabetes, 2022 Hyperinsulinemia promotes fat accumulation, causing obesity. Being an inflammatory state, obesity can induce further inflammation and is a risk factor for HPA (hypothalamic pituitary axis) dysregulation through hypercortisolism-related hyperglycemia.
Haider Sarwar +12 more
doaj +3 more sources
Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction
Journal of the Endocrine Society, 2019 Hyperinsulinemia is strongly associated with type 2 diabetes. Racial and ethnic minority populations are disproportionately affected by diabetes and obesity-related complications.
Nawfal Istfan +2 more
exaly +2 more sources
DPP4 Activity, Hyperinsulinemia and Atherosclerosis.
The Journal of Clinical Endocrinology & Metabolism, 2021 CONTEXT Obesity and type 2 diabetes are associated with chronic hyperinsulinemia, elevated plasma levels of dipeptidyl peptidase-4 (DPP4), and a pro-atherosclerotic milieu.
Kaitlin M. Love, Zhen-Qi Liu
semanticscholar +4 more sources
Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition
Developmental Cell, 2020 Metabolic diseases such as type 2 diabetes are associated with increased cancer incidence. Here, we show that hyperinsulinemia promotes epithelial tumorigenesis by abrogating cell competition.
Tatsushi Igaki +2 more
exaly +2 more sources