Results 11 to 20 of about 62,541 (232)

Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors

Open Veterinary Journal, 2023
Background: Sodium-Glucose CoTransporter-2 [SGLT2] inhibitors, the -flozin group of drugs, which block glucose reuptake in the renal proximal tubule, are being increasingly used off-label to treat horses with refractory hyperinsulinemia. After two years
Eleanor M. Kellon, Kathleen M. Gustafson
doaj   +1 more source

The rs12617336 and rs17574 Dipeptidyl Peptidase-4 Polymorphisms Are Associated With Hypoalphalipoproteinemia and Dipeptidyl Peptidase-4 Serum Levels: A Case-Control Study of the Genetics of Atherosclerotic Disease (GEA) Cohort

Frontiers in Genetics, 2021
Dipeptidyl peptidase-4 (DPP4) can influence lipid homeostasis and atherosclerosis progression. We aimed to assess the association of DPP4 gene polymorphisms with hypoalphalipoproteinemia and DPP4 serum levels, in a cohort of Mexican individuals.
Gilberto Vargas-Alarcón, María del Carmen González-Salazar, Christian Vázquez-Vázquez, Adrián Hernández-Díaz Couder, Fausto Sánchez-Muñoz, Juan Reyes-Barrera, Sergio A. Criales-Vera, Marco Sánchez-Guerra, Citlalli Osorio-Yáñez, Rosalinda Posadas-Sánchez   +9 more
doaj   +1 more source

Hyperinsulinemia: Best management practice [PDF]

, 2016
Chronic hyperinsulinemia associated with insulin resistance is directly and indirectly associated with many metabolic disorders that contribute to significant morbidity and mortality.
Crofts, Catherine Anne Price, Schofield, Grant M, Zinn, Caryn, Wheldon, Mark C   +3 more
core   +1 more source

Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease

Medicina, 2023
Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily increasing globally and seems to parallel the increasing prevalence of obesity.
Melvin R. Hayden
doaj   +1 more source

Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21 [PDF]

, 2009
OBJECTIVE—Fibroblast growth factor (FGF)-21 improves insulin sensitivity and lipid metabolism in obese or diabetic animal models, while human studies revealed increased FGF-21 levels in obesity and type 2 diabetes.
Pfeiffer, Andreas F. H., Meinus, S., Andres, Janin, Biedasek, Katrin, Biedasek, K., Spranger, J., Mai, K., Reinecke, F., Spuler, S., Pfeiffer, A.F., Moehlig, M., Sabath, Markus, Clemenz, M., Mai, Knut, Bobbert, T., Meinus, Sabine, Spranger, Joachim, Reinecke, Franziska, Weickert, Martin O., Bobbert, Thomas, Weicht, J., Möhlig, Matthias, Andres, J., Weicht, Jessica, Kintscher, U., Spuler, Simone, Clemenz, Markus, Sabath, M., Weickert, M.O., Kintscher, Ulrich   +29 more
core   +1 more source

The contribution of hyperinsulinemia to the hyperandrogenism of polycystic ovary syndrome

Journal of Metabolic Health, 2019
Background: Polycystic Ovary Syndrome (PCOS) is a very common endocrine disorder of young women. Aim: The proper treatment of PCOS requires a thorough understanding of the underlying cause of disease.
Nadia B. Pateguana, Alvin Janes
doaj   +1 more source

A Potential Role for Endogenous Glucagon in Preventing Post-Bariatric Hypoglycemia

Frontiers in Endocrinology, 2020
Obesity and obesity-related diseases are major public health concerns that have been exponentially growing in the last decades. Bariatric surgery is an effective long-term treatment to achieve weight loss and obesity comorbidity remission. Post-bariatric
Carolina B. Lobato, Carolina B. Lobato, Sofia S. Pereira, Sofia S. Pereira, Sofia S. Pereira, Sofia S. Pereira, Marta Guimarães, Marta Guimarães, Marta Guimarães, Bolette Hartmann, Bolette Hartmann, Nicolai J. Wewer Albrechtsen, Nicolai J. Wewer Albrechtsen, Nicolai J. Wewer Albrechtsen, Linda Hilsted, Jens J. Holst, Jens J. Holst, Mário Nora, Mário Nora, Mariana P. Monteiro, Mariana P. Monteiro   +20 more
doaj   +1 more source

A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity

Frontiers in Endocrinology, 2022
ObjectivesTo assess the benefit of a bariatric surgery in four artificial intelligence-identified metabolic (AIM) subtypes of obesity with respect to the improvement of glucometabolism and the remission of diabetes and hyperinsulinemia.MethodsThis ...
Yao Liu, Chunjun Sheng, Wenhuan Feng, Fang Sun, Jingjing Zhang, Jingjing Zhang, Ying Chen, Lili Su, Jia Liu, Lei Du, Xuyang Jia, Hui You, Xiu Huang, Shandong Wu, Shandong Wu, Shandong Wu, Ziwei Lin, Shen Qu   +17 more
doaj   +1 more source

Valproate Induced Obesity and Polycystic Ovaries

Pediatric Neurology Briefs, 1996
Fourteen (64%) of 22 women receiving valproate monotherapy for epilepsy had polycystic ovaries, hyperandrogenism, or both, in a study at the Departments of Neurology, Obstetrics and Gynecology, and Pediatrics, University of Oulu, Finland.
J Gordon Millichap
doaj   +1 more source

Hyperinsulinemia: A unifying theory of chronic disease? [PDF]

, 2015
Globally, there is an increasing prevalence of non-communicable diseases. The morbidity and mortality from these conditions confer a greater economic societal burden.
Crofts, Catherine Anne Price, Schofield, Grant, Zinn, Caryn, Wheldon, Mark   +3 more
core   +1 more source