Results 31 to 40 of about 3,033,419 (310)

Quantifying the improvement of surrogate indices of hepatic insulin resistance using complex measurement techniques [PDF]

, 2012
We evaluated the ability of simple and complex surrogate-indices to identify individuals from an overweight/obese cohort with hepatic insulin-resistance (HEP-IR).
Martin Osterhoff, Osterhoff Martin, Pfeiffer, Andreas F. H., Christian V Loeffelholz, Roden, Michael, Dr., Loeffelholz Christian v., Pfeiffer Andreas F. H., Nowotny, Peter, Möhlig Matthias, Nowotny Peter, Khan, Michael, Hattersley, John G., Weickert Martin O., Hierholzer, Johannes, Martin O Weickert, Arafat Ayman M., Roden Michael, Arafat, Ayman M., Machann Jürgen, Peter Nowotny, Weickert, Martin O., Möhlig, Matthias, Loeffelholz, Christian von, Hattersley John G., Michael Khan, Johannes Hierholzer, John G Hattersley, Matthias Möhlig, Michael Roden, Osterhoff, Martin, Khan Michael, Andreas F H Pfeiffer, Ayman M Arafat, Hierholzer Johannes, Jürgen Machann, Machann, Jürgen   +35 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Mechanisms of Insulin Action and Insulin Resistance [PDF]

Physiological Reviews, 2018
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. In the intervening century, some discoveries have matured, coalescing into solid and fertile ground for clinical application; others remain incompletely investigated and scientifically controversial.
Max C, Petersen, Gerald I, Shulman
openaire   +2 more sources

Hypothesis: ‘Vasocrine’ signalling from perivascular fat - a mechanism linking insulin resistance and vascular disease [PDF]

, 2005
Adipose tissue expresses cytokines which inhibit insulin signalling pathways in liver and muscle. Obesity also results in impairment of endothelium-dependent vasodilatation to insulin. We propose a vasoregulatory role for local deposits of fat around the
Stehouwer, C.D.A., Eringa, E., Eringa, Etto, Stehouwer, C.D.A.; id_orcid, Eringa, E.C., Stehouwer, Coen D.A., Yudkin, J.S., Yudkin, John S.   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Oral cabergoline for the management of equine pituitary pars intermedia dysfunction: Five cases

Open Veterinary Journal
Background: Oral pergolide has become the mainstay of treatment for equine pituitary pars intermedia dysfunction (PPID). It has a high success rate but some horses are, or become, refractory to the effects.
Eleanor M. Kellon
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b

Cellular & Molecular Biology Letters
Background The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network ...
Jérôme Gilleron, Abderrahman Chafik, Sandra Lacas-Gervais, Jean-François Tanti, Mireille Cormont   +4 more
doaj   +1 more source

Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance?

Nutrition & Diabetes, 2022
There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes.
Lauren Carmichael, Michelle A. Keske, Andrew C. Betik, Lewan Parker, Barbara Brayner, Katherine M. Roberts-Thomson, Glenn D. Wadley, D. Lee Hamilton, Gunveen Kaur   +8 more
doaj   +1 more source

Role of Insulin Resistance in Non-Obese Adolescents [PDF]

, 2010
2010-08Insulin resistance in the obese is closely related with cardiovascular diseases and their risk factors not only in adults but also in children and adolescents.
Koketsu, Masaaki, Nagashima, Masami, Inasaka, Hiroshi, Baba, Reizo, Tamakoshi, Akiko   +4 more
core   +1 more source