Results 41 to 50 of about 948,845 (312)

Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites

Biomedicines, 2022
The concept of insulin resistance has been around since a few decades after the discovery of insulin itself. To allude to the classic Charles Dicken’s novel published 62 years before the discovery of insulin, in some ways, this is the best of times, as ...
Elizabeth M. Rhea, William A. Banks, Jacob Raber   +2 more
doaj   +1 more source

Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome [PDF]

, 2013
Context/Objective: Current diagnostic criteria for polycystic ovary syndrome (PCOS) have generated distinct PCOS phenotypes, based on the different combinations of diagnostic features found in each patient.
Bonin, Cecilia, Bonora, Enzo, Dall'Alda, Marlene, Di Sarra, Daniela, Fiers, Tom, Giagulli, Vito Angelo, Kaufman, Jean, Moghetti, Paolo, Signori, Chiara, Spiazzi, Giovanna, Tosi, Flavia, Zambotti, Francesca, Zanolin, Maria Elisabetta   +12 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Metabolic syndrome and insulin resistance in obese adolescents

Revista Paulista de Pediatria, 2014
Objective: To verify the prevalence of metabolic syndrome and insulin resistance in obese adolescents and its relationship with different body composition indicators.
Amanda Oliva Gobato, Ana Carolina J. Vasques, Mariana Porto Zambon, Antonio de Azevedo Barros Filho, Gabriel Hessel   +4 more
doaj   +1 more source

Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance?

Nutrition & Diabetes, 2022
There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes.
Lauren Carmichael, Michelle A. Keske, Andrew C. Betik, Lewan Parker, Barbara Brayner, Katherine M. Roberts-Thomson, Glenn D. Wadley, D. Lee Hamilton, Gunveen Kaur   +8 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b

Cellular & Molecular Biology Letters
Background The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network ...
Jérôme Gilleron, Abderrahman Chafik, Sandra Lacas-Gervais, Jean-François Tanti, Mireille Cormont   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Sustained expression of hemopexin in an animal model of sickle cell anemia

Blood Vessels, Thrombosis & Hemostasis
: Sickle cell disease is a condition characterized by vaso-occlusive episodes and sustained hemolysis, leading to a chronic inflammatory state. Several studies have shown that the release of heme to the extracellular space due to hemolysis contributes to
Franciele De Lima, Carla Roberta Peachazepi De Moraes, Ivanio Teixeira Borba-Junior, Heloísa Balan Assalin, Mario José Abdalla Saad, Fernando Ferreira Costa, Erich V. De Paula   +6 more
doaj   +1 more source

Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats

Cardiovascular Diabetology, 2008
Despite the marked advances in research on insulin resistance (IR) in humans and animal models of insulin resistance, the mechanisms underlying high salt-induced insulin resistance remain unclear.
Shehata Marlene F
doaj   +1 more source