Results 61 to 70 of about 3,202,592 (310)

Myocardial Insulin Resistance: An Overview of Its Causes, Effects, and Potential Therapy

, 2012
: Insulin resistance ensues when normal physiological concentrations of insulin are unable to induce effective cellular insulin signalling and glucose uptake by insulin sensitive tissues.
Daniel G., Eugene F. du Toit, Du Toit, Eugene, Donner, Dan   +3 more
core   +1 more source

Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. [PDF]

, 2014
Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin ...
Monty G. Mythen (551722), Carl A Leckstrom, Mythen, Monty G., Mario Siervo, Hugh E Montgomery, Monty G Mythen, Fernandez, Bernadette O, Feelisch, Martin, Bernadette O. Fernandez (358499), Kay Mitchell, Martin Feelisch, Siervo, Mario, Riley, Heather L., Fernandez, Bernadette O., Montgomery, Hugh E., Martin Feelisch (358503), Michael P W Grocott, Heather L. Riley (551717), HASH(0x55a67fe3ce10), Michael P. W. Grocott (551723), Denny Z H Levett, Caudwell Xtreme Everest Research Group, Mario Siervo (359964), Denny Z. H. Levett (551721), Carl A. Leckstrom (551718), Levett, Denny Z.H., Bernadette O Fernandez, Daniel S Martin, Hugh E. Montgomery (364638), Grocott, Michael P. W., Levett, Denny Z. H., Leckstrom, Carl A., Martin, Daniel S., Kay Mitchell (551720), Daniel S. Martin (551719), Mitchell, Kay, Heather L Riley, Fernandez Bernadette O., Grocott Michael P. W., Montgomery Hugh E., Leckstrom Carl A., Siervo Mario, Mitchell Kay, Feelisch Martin, Martin Daniel S., Riley Heather L., Mythen Monty G., Levett Denny Z. H.   +47 more
core   +2 more sources

Obesity and insulin resistance: Pathophysiology and treatment

, 2021
The prevalence of obesity is a major cause of many chronic metabolic disorders, including type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and cancer.
Tong, Y, Huang, L, Chen, C, Xu, S, Chen Chen, Lili Huang, Sai Xu, Yue Tong   +7 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Inflammation, insulin resistance, and diabetes : mendelian randomization using CRP haplotypes points upstream [PDF]

, 2008
Background Raised C-reactive protein (CRP) is a risk factor for type 2 diabetes. According to the Mendelian randomization method, the association is likely to be causal if genetic variants that affect CRP level are associated with markers of diabetes ...
Timpson, NJ, Daniel R Witte, Kumari, Meena, Brunner, Eric J, Nicholas J Timpson, Witte Daniel R, Shah Tina, Kumari, M., Michelle Miller, Smith George Davey, Smith, GD, Humphries, SE, Smith, G.D., Aroon D Hingorani, Hingorani, AD, Marmot, MG, Rumley, A., Ann Rumley, Kumari Meena, Meena Kumari, Steve E Humphries, Michael G Marmot, Kumari, M, Witte, Daniel R, Shah, T, Casas, Juan P., Miller, M., Lowe, G.D., Marmot, Michael G, Juan P Casas, Rumley, Ann, Smith, George Davey, Shah, Tina, Humphries, S.E., Witte, DR, Gordon D O Lowe, Brunner Eric J, Lawlor, DA, Cooper Jackie A, Humphries Steve E, Cooper, J.A., Brunner, Eric, Hingorani, Aroon D, Marmot Michael G, Cooper, Jackie A., Miller, Michelle A., Lawlor, D.A., Witte, D.R., Timpson, Nicholas J., Lowe, GDO, Kivimäki, Mika, Casas Juan P, Mika Kivimäki, Cooper, Jackie A, Witte, Daniel R., Kivimaki, M., Kivimäki Mika, Miller, Michelle, Lawlor, Debbie A, Lowe, Gordon DO, Hingorani, A.D., Marmot, M.G., Humphries, Steve E, Tina Shah, Marmot, Michael G., Davey Smith, G, Lowe Gordon D. O, Brunner, EJ, Lowe, GD, Hingorani Aroon D, Cooper, JM, Lowe, G. D. O., Timpson, Nicholas J, Timpson Nicholas J, Brunner, E.J., Kivimaki, MJ, Lawlor, D, Casas, Juan P, Lawlor, Debbie A., Cooper, JA, Miller, M, Kivimaki, M, Eric J Brunner, Jackie A Cooper, Timpson, N.J., Debbie A Lawlor, Miller Michelle, Shah, T., Casas, JP, George Davey Smith, Rumley Ann, Casas, J.P., Rumley, A, Lawlor Debbie A, Humphries, Steve E., Hingorani, Aroon   +95 more
core   +1 more source

Obesity and insulin resistance [PDF]

Journal of Clinical Investigation, 2000
The association of obesity with type 2 diabetes has been recognized for decades, and the major basis for this link is the ability of obesity to engender insulin resistance. Insulin resistance is a fundamental aspect of the etiology of type 2 diabetes and is also linked to a wide array of other pathophysiologic sequelae including hypertension ...
B B, Kahn, J S, Flier
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
Aims/HypothesisReduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve insulin sensitivity but blunt ...
Hage Hassan, Rima, Hundal, Harinder S, Gray, Alexander; id_orcid, Lipina Christopher, Hundal, Harinder S., Alexander Gray, Hajduch, Eric, Rima Hage Hassan, David Magill, Eric Hajduch, Hage Hassan Rima, Nardi, Francesca, Francesca Nardi, Hajduch Eric, Magill David, Gray, Alexander, Hundal Harinder S., Lipina, Christopher, Nardi Francesca, Harinder S Hundal, Magill, David, Christopher Lipina, Gray Alexander   +22 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source