Results 61 to 70 of about 635,089 (319)

Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats

Cardiovascular Diabetology, 2008
Despite the marked advances in research on insulin resistance (IR) in humans and animal models of insulin resistance, the mechanisms underlying high salt-induced insulin resistance remain unclear.
Shehata Marlene F
doaj   +1 more source

Changing Clinical Characteristics according to Insulin Resistance and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients in Korea [PDF]

Diabetes & Metabolism Journal, 2015
BackgroundThe role of increased insulin resistance in the pathogenesis of type 2 diabetes has been emphasized in Asian populations. Thus, we evaluated the proportion of insulin resistance and the insulin secretory capacity in patients with early phase ...
Jang Won Son, Cheol-Young Park, Sungrae Kim, Han-Kyu Lee, Yil-Seob Lee,   +5 more
doaj   +1 more source

Inflammation, insulin resistance, and diabetes : mendelian randomization using CRP haplotypes points upstream [PDF]

, 2008
Background Raised C-reactive protein (CRP) is a risk factor for type 2 diabetes. According to the Mendelian randomization method, the association is likely to be causal if genetic variants that affect CRP level are associated with markers of diabetes ...
Timpson, NJ, Daniel R Witte, Kumari, Meena, Brunner, Eric J, Nicholas J Timpson, Witte Daniel R, Shah Tina, Kumari, M., Michelle Miller, Smith George Davey, Smith, GD, Humphries, SE, Smith, G.D., Aroon D Hingorani, Hingorani, AD, Marmot, MG, Rumley, A., Ann Rumley, Kumari Meena, Meena Kumari, Steve E Humphries, Michael G Marmot, Kumari, M, Witte, Daniel R, Shah, T, Casas, Juan P., Miller, M., Lowe, G.D., Marmot, Michael G, Juan P Casas, Rumley, Ann, Smith, George Davey, Shah, Tina, Humphries, S.E., Witte, DR, Gordon D O Lowe, Brunner Eric J, Lawlor, DA, Cooper Jackie A, Humphries Steve E, Cooper, J.A., Brunner, Eric, Hingorani, Aroon D, Marmot Michael G, Cooper, Jackie A., Miller, Michelle A., Lawlor, D.A., Witte, D.R., Timpson, Nicholas J., Lowe, GDO, Kivimäki, Mika, Casas Juan P, Mika Kivimäki, Cooper, Jackie A, Witte, Daniel R., Kivimaki, M., Kivimäki Mika, Miller, Michelle, Lawlor, Debbie A, Lowe, Gordon DO, Hingorani, A.D., Marmot, M.G., Humphries, Steve E, Tina Shah, Marmot, Michael G., Davey Smith, G, Lowe Gordon D. O, Brunner, EJ, Lowe, GD, Hingorani Aroon D, Cooper, JM, Lowe, G. D. O., Timpson, Nicholas J, Timpson Nicholas J, Brunner, E.J., Kivimaki, MJ, Lawlor, D, Casas, Juan P, Lawlor, Debbie A., Cooper, JA, Miller, M, Kivimaki, M, Eric J Brunner, Jackie A Cooper, Timpson, N.J., Debbie A Lawlor, Miller Michelle, Shah, T., Casas, JP, George Davey Smith, Rumley Ann, Casas, J.P., Rumley, A, Lawlor Debbie A, Humphries, Steve E., Hingorani, Aroon   +95 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites

Biomedicines, 2022
The concept of insulin resistance has been around since a few decades after the discovery of insulin itself. To allude to the classic Charles Dicken’s novel published 62 years before the discovery of insulin, in some ways, this is the best of times, as ...
Elizabeth M. Rhea, William A. Banks, Jacob Raber   +2 more
doaj   +1 more source

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. [PDF]

, 2011
OBJECTIVE: The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally ...
Gaunt, TR, Weedon, Michael N., De Silva, N. Maneka G., Weedon, MN, Luan, Jian'an, Harbord, Roger M., Harbord, Roger M, Ward, Kirsten J, Luan, J, Smith, GD, N. Maneka G. De Silva, Morris, Andrew D, Morris, Andrew D., Gaunt, Tom, Ebrahim, S, Ward, KJ, Claudia Langenberg, Knight, Beatrice A., Donnelly, Louise A, Beverley Shields, McCarthy, Mark I, Shah Ebrahim, De Silva, N. Maneka G, Palmer, Colin N A, Timothy M. Frayling, Ebrahim, Shah, Tom Gaunt, Debbie A. Lawlor, Rachel M. Freathy, Sandhu, MS, Ebrahim, Shah B J, Sandhu, Manjinder S., Hattersley, Andrew T., Harbord, RM, Beatrice A. Knight, Hattersley, Andrew T, Smith, George Davey, Palmer, Colin N. A., Knight, Beatrice A, Lawlor, DA, Louise A. Donnelly, Knight, BA, Langenberg, C, Freathy, RM, Roger M. Harbord, Freathy, Rachel M, Andrew T. Hattersley, Weedon, Michael N, Hattersley, AT, Palmer, CN, McCarthy, MI, Michael N. Weedon, Palmer, Tom M, Sandhu, Manjinder S, Palmer, CNA, Shields, B, Lawlor, Debbie A, Andrew D. Morris, Langenberg, Claudia, Shields, Beverley, De Silva, N Maneka G, Ward, Kirsten J., Mark I. McCarthy, Palmer, Colin NA, Donnelly, LA, De Silva, NM, Davey Smith, G, Frayling, Timothy M., Wareham, N, Tom M. Palmer, Gaunt, T, Nicholas Wareham, Morris, AD, Jian'an Luan, Lawlor, D, Manjinder S. Sandhu, Lawlor, Debbie A., Wareham, Nicholas, McCarthy, Mark I., Freathy, Rachel M., Palmer, TM, Frayling, Timothy M, Kirsten J. Ward, Donnelly, Louise A., George Davey Smith, Palmer, Tom M., De Silva, N M G, Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +89 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Obesity and Cardiovascular Risk: Variations in Visfatin Gene Can Modify the Obesity Associated Cardiovascular Risk. Results from the Segovia Population Based-Study. Spain.

PLoS ONE, 2016
ObjectivesOur aim was to investigate if genetic variations in the visfatin gene (SNPs rs7789066/ rs11977021/rs4730153) could modify the cardiovascular-risk (CV-risk) despite the metabolic phenotype (obesity and glucose tolerance).
María Teresa Martínez Larrad, Arturo Corbatón Anchuelo, Cristina Fernández Pérez, Milagros Pérez Barba, Yera Lazcano Redondo, Manuel Serrano Ríos, Segovia Insulin Resistance Study Group (SIRSG)   +6 more
doaj   +1 more source

Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans [PDF]

, 2010
Objective: To study the association of vaspin with glucose metabolism. Design: Cross-sectional and intervention study. Subjects and methods: The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108
Isken, Frank, Randeva, Harpal S., Spranger, Joachim, Weickert, Martin O., Pfeiffer, Andreas F. H., Loeffelholz, Christian von, Möhlig, Matthias, Mai, Knut, Arafat, Ayman, M.   +8 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source