Results 71 to 80 of about 3,033,419 (310)

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

eLife, 2018
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue.
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James   +23 more
doaj   +1 more source

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
Aims/HypothesisReduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve insulin sensitivity but blunt ...
Hage Hassan, Rima, Hundal, Harinder S, Gray, Alexander; id_orcid, Lipina Christopher, Hundal, Harinder S., Alexander Gray, Hajduch, Eric, Rima Hage Hassan, David Magill, Eric Hajduch, Hage Hassan Rima, Nardi, Francesca, Francesca Nardi, Hajduch Eric, Magill David, Gray, Alexander, Hundal Harinder S., Lipina, Christopher, Nardi Francesca, Harinder S Hundal, Magill, David, Christopher Lipina, Gray Alexander   +22 more
core   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease[S]

Journal of Lipid Research, 2017
We aimed to determine the risk factors associated with the depletion of large HDL particles and enrichment of small HDL particles observed in adolescents with T2D.
W. Sean Davidson, Anna Heink, Hannah Sexmith, Lawrence M. Dolan, Scott M. Gordon, James D. Otvos, John T. Melchior, Deborah A. Elder, Jane Khoury, Esmond Geh, Amy S. Shah   +10 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Mechanisms of Insulin Resistance in Patients with Obesity

Endocrines
Introduction: Insulin resistance is a common condition affecting thousands of people worldwide. This paper aims to examine the mechanisms underlying insulin resistance among people suffering from obesity.
Borros Arneth
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects

Journal of Lipid Research, 2012
Insulin resistance in adipose tissue increases the release of free fatty acids into the circulation, which likely contributes to impaired insulin action in liver and skeletal muscle associated with obesity.
Elisa Fabbrini, Faidon Magkos, Caterina Conte, Bettina Mittendorfer, Bruce W. Patterson, Adewole L. Okunade, Samuel Klein   +6 more
doaj   +1 more source

Insulin Resistance in PCOS

Endocrine, 2006
Polycystic ovary syndrome (PCOS) is the commonest endocrinopathy affecting women of reproductive age, manifested with a variety of clinical signs, none of which is pathognomonic. The association of insulin resistance and reproductive abnormalities with clinical hyperandrogenism in a woman was first demonstrated by Achard and Thiers in the "diabetes of ...
openaire   +3 more sources

Microalbuminuria and Insulin Resistance

, 2009
The glomerular barrier is highly selective and only minute amounts reaches the urine. Normally, the daily loss of albumin in urine is less than 30 mg and microalbuminuria denotes losses between 30-300 mg per day.
Haraldsson, Börje,
core