Results 71 to 80 of about 635,089 (319)

Effects of a Circuit Training Program on Myokine Levels in Insulin-Resistant Women: A Randomised Controlled Trial

Journal of Diabetes Research
Conclusion: The circuit training program implemented in women newly diagnosed with insulin resistance significantly increased their serum IL-6 and not their IL-10, FGF21, and irisin levels.
Joanna Karolkiewicz, Monika Krzywicka, Monika Szulińska, Katarzyna Musialik, Dominka Musiałowska, Jacek Zieliński, Agnieszka Bilska, Marzena Ratajczak   +7 more
doaj   +1 more source

Mechanisms linking glucotoxicity to the development of insulin resistance: a role for the endoplasmic reticulum stress [PDF]

, 2010
Aims/hypothesis: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of ER stress in the induction of insulin-resistance by glucosamine in skeletal muscle cells. Methods:
Iadicicco, Claudia
core  

A gene expression signature for insulin resistance [PDF]

, 2011
Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiology varies considerably between individuals.
Foletta, Victoria C., Andrew Sanigorski, Curran, Joanne E., Connor, Tim, Krippner, Guy, Fahey, Richard P., Collier, Greg R., Sanigorski, Andrew, Windmill, Kelly, Watt, Rose A., Joanne E. Curran, Juan-Carlos Molero, Jeremy B. Jowett, John Blangero, Stephen Wanyonyi, Tim Connor, Jowett, Jeremy B., Dyer, Thomas D., Shields, Katherine A., James, David E., Wanyonyi, Stephen, Konstantopoulos, Nicky, Courtney Swinton, Ken R. Walder, Walder, Ken R., Richard P. Fahey, Thomas D. Dyer, Nicky Konstantopoulos, Guy Krippner, Segal, David H., Katherine A. Shields, Victoria C. Foletta, Molero, Juan C., Blangero, John, David H. Segal, Kelly Windmill, Greg R. Collier, David E. James, Rose A. Watt, Swinton, Courtney   +39 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Insulin dynamics in young women with polycystic ovary syndrome and normal glucose tolerance across categories of body mass index.

PLoS ONE, 2014
BackgroundEvidence favours insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps primary, defects in polycystic ovary syndrome (PCOS). The aim of the present study was to evaluate insulin metabolism in young women with PCOS but
Melania Manco, Lidia Castagneto-Gissey, Eugenio Arrighi, Annamaria Carnicelli, Claudia Brufani, Rosa Luciano, Geltrude Mingrone   +6 more
doaj   +1 more source

Insulin Secretion In Insulin Resistance States [PDF]

, 2015
Insulin secretion is regulated mainly by glucose stimulus changes and is characterized by first and second phase (biphasic time course). β-cell glucose sensitivity is essential to maintain glucose homeostasis and loss of that capacity has been related to
De Barros-Mazon S., Alegre S.M., Marin D.M.   +2 more
core  

The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Hisadome, Kazunari, Choudhury, Agharul I., Smith, Mark A., Simmgen, M., Diakonov, Ivan, Allison W. Xu, Bedford, D.C., Michael L.J. Ashford, Speakman, J.R., Helen Heffron, Bedford, David C., Selman, Colin, Marc Claret, Xu, Allison W., Kazunari Hisadome, Claret, Marc, MacColl, Gavin, Bell, Jimmy D., Speakman, John R., Heffron, H., Melanie Clements, Barsh, Gregory S., Agharul I. Choudhury, Choudhury, A.I., Heffron, Helen, Hind Al-Qassab, Xu, A.W., Vazira Moosajee, Withers, D.J., Hisadome, K., Barsh, G.S., Clements, Melanie, Mark A. Smith, Ashford, Michael L.J.; id_orcid, Withers, Dominic J., Moosajee, Vazira, Dominic J. Withers, Claret, M., MacColl, G., Selman, C., Ivan Diakonov, Al-Qassab, H., Al-Qassab, Hind, Moosajee, V., Gavin MacColl, Simmgen, Marcus, Bell, J.D., Smith, M.A., Ashford, M.L.J., Gregory S. Barsh, Diakonov, I., Batterham, R.L., David C. Bedford, Batterham, Rachel L., Colin Selman, Jimmy D. Bell, Clements, M., Marcus Simmgen, Rachel L. Batterham, John R. Speakman   +59 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Research progress on the role of FGF21 in insulin resistance

Frontiers in Endocrinology
The elevated global prevalence of metabolic syndrome and type 2 diabetes mellitus (T2DM) has led to a dramatic increase in patients with insulin resistance.
Haixin Zhang, Rongyu Zhu, Quanhao Sun, Likun Du   +3 more
doaj   +1 more source

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

eLife, 2018
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue.
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James   +23 more
doaj   +1 more source