Results 91 to 100 of about 3,202,592 (310)

Deficiency of the bone mineralization inhibitor NPP1 protects against obesity and diabetes [PDF]

, 2014
The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease.
Elspeth M. Milne, Ahmed, S Faisal, Zhu, Dongxing, Morton, Nicholas M, Millan, José Luis, MacRae, Vicky E, Mathieu Ferron, José Luis Millan, Dongxing Zhu, Nicholas M. Morton, Ferron, Mathieu, Farquharson, Colin, Karsenty, Gerard, Gerard Karsenty, Carmen Huesa, Vicky E. MacRae, Morton, Nicholas M., James D. Glover, Ahmed, S. Faisal, Glover, James D, Colin Farquharson, Huesa, Carmen, MacRae, Vicky E., S. Faisal Ahmed, Glover, James D., Milne, Elspeth M, Milne, Elspeth M., Farquharson, Colin; id_orcid   +27 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Insulin resistance and its relation to adiposity, cardiorespiratory fitness and dietary intake among Azorean adolescents [PDF]

, 2012
Insulin resistance is an important compo nent in the development of metabolic syndrome and lifestyle-related diseases. The aim of the present study is to investigate the relationship between insulin resistance (IR), adiposity, cardiorespiratory fitness ...
Soares-Miranda, L., Vale, S., Marques, A. I., Santos, P. C., Moreira, C., Abreu, S., Rute, Santos, Mota, J.   +7 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans [PDF]

, 2010
Objective: To study the association of vaspin with glucose metabolism. Design: Cross-sectional and intervention study. Subjects and methods: The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108
Isken, Frank, Randeva, Harpal S., Spranger, Joachim, Weickert, Martin O., Pfeiffer, Andreas F. H., Loeffelholz, Christian von, Möhlig, Matthias, Mai, Knut, Arafat, Ayman, M., Frank Isken, Knut Mai, Matthias Möhlig, Joachim Spranger, Harpal S Randeva, Christian von Loeffelholz, Andreas F H Pfeiffer, Martin O Weickert, Ayman M Arafat   +17 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Effects of habitual endurance and resistance exercise on insulin action in primary human skeletal muscle stem cells

Physiological Reports
Endurance‐oriented exercise typically enhances insulin action in skeletal muscle; however, relatively little is known about the impact of resistance exercise. In the present study, insulin action was determined in primary human skeletal muscle stem cells
Polina Krassovskaia, Filip Jevtovic, Donghai Zheng, John Noone, Reichelle X. Yeo, Maria F. Pino, Cynthia L. Stowe, Shannon S. Emilson, Nicolas Musi, Kim M. Huffman, Caitlin Hebert, Sophia Bowen, Simona Zarini, Eric Ravussin, Nicholas T. Broskey, William E. Krauss, Bryan C. Bergman, Lauren M. Sparks, Joseph A. Houmard   +18 more
doaj   +1 more source

The Effects of Engeletin on Insulin Resistance Induced in Human HepG2 Liver Cells

Current Issues in Molecular Biology
In this study, we aimed to investigate the effect of Engeletin (ENG) on insulin resistance and the associated oxidative cell damage in human HepG2 liver cells. The cells were grown in a cell culture medium, and insulin resistance was induced.
Erdem Toktay, Secil Nazife Parlak, Tugba Kavas, Harun Un, Rustem Anıl Ugan, Muhammed Yayla   +5 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source