Results 101 to 110 of about 948,845 (312)

Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System

Biomedicines
Hyperinsulinemia refers to an elevated level of circulating insulin (80 and 100 µU/mL), often leading to metabolic disorders such as obesity, insulin resistance, and type 2 diabetes (T2D).
Ghassan Bkaily, Ashley Jazzar, Amira Abou-Aichi, Danielle Jacques   +3 more
doaj   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

The Effects of Engeletin on Insulin Resistance Induced in Human HepG2 Liver Cells

Current Issues in Molecular Biology
In this study, we aimed to investigate the effect of Engeletin (ENG) on insulin resistance and the associated oxidative cell damage in human HepG2 liver cells. The cells were grown in a cell culture medium, and insulin resistance was induced.
Erdem Toktay, Secil Nazife Parlak, Tugba Kavas, Harun Un, Rustem Anıl Ugan, Muhammed Yayla   +5 more
doaj   +1 more source

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]

, 2014
Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre, Antonescu, Bain, Boppart, Cancello, Cao, Carlson, Caroline P. Wheeler-Jones, Cazzolli, Chavez, Cleasby, Coll, Corraliza, de Alvaro, De Paepe, Devaraj, Diamond-Stanic, Dimopoulos, Elgazar-Carmon, Festa, Fink, Fujishiro, Gao, Griffin, Haversen, Hemi, Hevener, Hirabara, Hirosumi, Hoehn, Hommelberg, Hotamisligil, Hotamisligil, Hwang, Kadotani, Karten, Kewalramani, Kuma, Lee, Lee, Liang, Lumeng, Lumeng, Maekawa, Mark E. Cleasby, McCall, Nguyen, Nicola A. Talbot, Patel, Pillon, Pinnick, Plomgaard, Polkinghorne, Prieur, Samokhvalov, Schilling, Sell, Shi, Solinas, Storlien, Suganami, Tardif, Thong, Turner, Uysal, Varma, Weisberg, Yuan   +67 more
core   +2 more sources

Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications

Advanced Functional Materials, EarlyView.
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi, Norma Mallegni, Andrea Dorigato, Mario Milazzo   +3 more
wiley   +1 more source

Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. [PDF]

, 2013
ObjectiveWe aimed to identify factors that are independently associated with the metabolic clearance rate of insulin (MCRI) and to examine the association of MCRI with incident type 2 diabetes in nondiabetic Hispanics and African Americans.Research ...
Anderson, Andrea M, Bergman, Richard N, Goodarzi, Mark O, Haffner, Steven M, Hanley, Anthony J, Lee, C Christine, Lorenzo, Carlos, Norris, Jill M, Rotter, Jerome I, Stefanovski, Darko, Wagenknecht, Lynne E   +10 more
core   +2 more sources

Transfer Printing and Reconfiguration of Soft Electronics Using Digital Microfluidics and Laser Machining

Advanced Functional Materials, EarlyView.
This paper presents a digital microfluidics‐based technique for transferring and reconfiguring soft nanomembranes. Laser‐machined nanothin membranes are picked up, transported, and aligned via tailored surface tension and the actuation of water droplets, enabling the development of flexible electronics, the integration of functional materials on 3D ...
Quang Anh Nguyen, Chi Cong Nguyen, Tran Bach Dang, Phuoc Thien Phan, Jordan Thorpe, Michael Listyawan, Nhat Minh Doan, Sinuo Zhao, Hongru Chen, Trung Thien Hoang, Mingsheng Xu, Jisheng Han, Thanh Nho Do, Adam Hill, Timothée Mouterde, Hoang‐Phuong Phan   +15 more
wiley   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]

, 2017
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I, Chen, Tzu-Chieh, Costello, Damian E, Kuo, Taiyi, Lee, Rebecca A, Li, Mei-Lan, Mar, Darryl J, Nomura, Daniel K, Wang, Jen-Chywan   +8 more
core   +1 more source

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source