Results 81 to 90 of about 3,033,419 (310)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Role of the IRS-1 and/or -2 in the pathogenesis of insulin resistance in Dahl salt-sensitive (S) rats

Heart International, 2009
Insulin resistance is a common finding in hypertensive humans and animal models. The Dahl salt-sensitive (S) rat is an ideal model of genetically predetermined insulin resistance and salt-sensitive hypertension.
Marlene F. Shehata
doaj   +1 more source

Insulin resistance in morbid obesity: Reversal with intramyocellular fat depletion

, 2002
Obesity is a frequent cause of insulin resistance and poses a major risk for diabetes. Abnormal fat deposition within skeletal muscle has been identified as a mechanism of obesity-associated insulin resistance. We tested the hypothesis that dietary lipid
CAMASTRA S, MANCO M., VETTOR R., MANCO M, Vettor R, CAMASTRA, STEFANIA, MORRONI M, GRANZOTTO M., GRECO AV, MINGRONE G, CINTI, Saverio, MORRONI, MANRICO, GRECO A.V., CINTI S, Mingrone, Geltrude, GIANCATERINI A, GRANZOTTO M, CAMASTRA S., FERRANNINI E., Greco, Aldo Virgilio, FERRANNINI, ELEUTERIO, GIANCANTERINI A., VETTOR, ROBERTO, MINGRONE G.   +23 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Prolonged exposure to insulin might cause epigenetic alteration leading to insulin resistance

FEBS Open Bio
Glucose homeostasis is maintained by insulin. Insulin resistance is caused by multiple factors including hereditary factors and diet. The molecular mechanism underlying insulin resistance (IR) is not completely understood. Hyperinsulinemia often precedes
Shehnaz Bano, Shyam More, Dattatray S. Mongad, Abdul Khalique, Dhiraj P. Dhotre, Manoj K. Bhat, Vasudevan Seshadri   +6 more
doaj   +1 more source

Icariin Attenuates Amyloid-β (Aβ)-Induced Neuronal Insulin Resistance Through PTEN Downregulation

Frontiers in Pharmacology, 2020
Neuronal insulin resistance is implicated in neurodegenerative diseases. Icariin has been reported to improve insulin resistance in skeletal muscle cells and to restore impaired hypothalamic insulin signaling in the rats with chronic unpredictable mild ...
Xiaomei Zou, Xiyao Feng, Yalin Fu, Yalin Fu, Yuyang Zheng, Yuyang Zheng, Mingke Ma, Mingke Ma, Changhua Wang, Changhua Wang, Yemin Zhang, Yemin Zhang   +11 more
doaj   +1 more source

Obesity and Insulin Resistance metabolic relation and the Management of Insulin Resistance

, 2019
Insulin, since its discovery in the 19th century until our days, has been considered as one of the biggest interests of researchers in medicine. insulin synthesis in the pancreatic islet cells is stimulated by glucose and inhibited by fasting, as glucose
Egbaria, Olfat
core  

Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation [PDF]

, 2018
Pre-clinical data and human trials indicate that resveratrol supplementation may help to counteract diabetes. Several mechanisms of action have been proposed to explain its metabolic benefits, including activation of sirtuins and estrogen receptors (ER ...
Wong, Rachel H. X., Howe, Peter R. C., Rachel H. X. Wong, Peter R. C. Howe   +3 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Evaluation of glucose tolerance test and surrogate indexes of insulin sensitivity to detect insulin resistance syndrome in transition dairy cows [PDF]

, 2013
Healthy multiparous Holstein-Fresian cows (n=101, parity ≥ 2) from 3 large-scale dairy herds in Italy were subjected to an intravenous glucose tolerance test (GTT) 14-1 d before (Week -1) and 3-9 d after calving (Week +1).
Riuzzi, Sara
core