Results 51 to 60 of about 3,033,419 (310)

Changing Clinical Characteristics according to Insulin Resistance and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients in Korea [PDF]

Diabetes & Metabolism Journal, 2015
BackgroundThe role of increased insulin resistance in the pathogenesis of type 2 diabetes has been emphasized in Asian populations. Thus, we evaluated the proportion of insulin resistance and the insulin secretory capacity in patients with early phase ...
Jang Won Son, Cheol-Young Park, Sungrae Kim, Han-Kyu Lee, Yil-Seob Lee,   +5 more
doaj   +1 more source

Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites

Biomedicines, 2022
The concept of insulin resistance has been around since a few decades after the discovery of insulin itself. To allude to the classic Charles Dicken’s novel published 62 years before the discovery of insulin, in some ways, this is the best of times, as ...
Elizabeth M. Rhea, William A. Banks, Jacob Raber   +2 more
doaj   +1 more source

Role of Myotonic Dystrophy Protein Kinase [DMPK] in Glucose Homeostasis and Muscle Insulin Action [PDF]

, 2007
Myotonic dystrophy 1 (DM1) is caused by a CTG expansion in the 3′-unstranslated region of the DMPK gene, which encodes a serine/threonine protein kinase. One of the common clinical features of DM1 patients is insulin resistance, which has been associated
Liesa Marc, Ciaraldi, Theodore P, Martí, Luc, Ciaraldi, Theodore P., Palacin, Manuel, Catalucci, Daniele, Wolfgang H Dillmann, Esther Llagostera, Perla Kaliman, Catalucci Daniele, Camps, Marta, Reddy, Sita, Gomis, Ramon, 1946-, Luc Marti, Llagostera Martín, Esther, Antonio Zorzano, Ciaraldi Theodore P., Dillmann, Wolfgang H, Llagostera Esther, Gomis Ramon, Reddy Sita, Camps Marta, Dillmann, Wolfgang H., Kaliman Perla, Sita Reddy, Kaliman, Perla, Ruiz-Lozano Pilar, Llagostera, Esther, Richard Kondo, Ruiz-Lozano, Pilar, Zorzano Olarte, Antonio, Manuel Palacin, Zorzano Antonio, Kondo, Richard, Palacín Prieto, Manuel, Ramon Gomis, Daniele Catalucci, Liesa Torre-Marín, Montserrat, Dillmann Wolfgang H., Marti Luc, Camps Camprubí, Marta, Zorzano, Antonio, Marta Camps, Pilar Ruiz-Lozano, Liesa, Marc, Kondo Richard, Gomis, Ramon, Marc Liesa, Theodore P Ciaraldi, Palacin Manuel   +49 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Rab4b controls hepatic glucose production during fasting through glycophagy

Nature Communications
Hepatic glucose production, essential for maintaining glycemia, is often altered in metabolic-associated fatty liver and glycogen storage diseases. Therefore, understanding the mechanisms that regulate the glucose production by hepatocyte is pivotal ...
Marion Dussot, Lucie Le Parc, Sihame Sabbane, Alycia Zedda, Abderrahman Chafik, Alexandre Gallerand, Karine Dumas, Stéphanie Bonnafous, Yun Kwon, Sandra Lacas-Gervais, Charlotte Hinault Boyer, Giulia Chinetti, Sophie Giorgetti-Peraldi, Philippe Gual, Stoyan Ivanov, Anja Zeigerer, Jean-François Tanti, Mireille Cormont, Jerome Gilleron   +18 more
doaj   +1 more source

Enhanced mitochondrial superoxide scavenging does not Improve muscle insulin action in the high fat-fed mouse [PDF]

, 2015
Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or transgenically expressing catalase
Jeffrey S. Bonner¤b, Daniel S. Lark, Wasserman David H., Mary E Lustig, Darrell Neufer, David H. Wasserman, Lark Daniel S., Lustig, Mary E., Freyja D James, Bonner, Jeffrey S, Kang Li, James Freyja D., NC DOCKS at East Carolina University, Lark, Daniel Stephen, P Darrell Neufer, Freyja D. James, Lark, Daniel S., Wasserman, David H., Kang, Li, Bonner Jeffrey S., Daniel S Lark, Lustig Mary E., Bonner, Jeffrey S., Neufer P. Darrell, Mary E. Lustig, Neufer, Darrell, Neufer, P. Darrell, David H Wasserman, James, Freyja D., Jeffrey S Bonner, Li Kang   +30 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Obesity and Cardiovascular Risk: Variations in Visfatin Gene Can Modify the Obesity Associated Cardiovascular Risk. Results from the Segovia Population Based-Study. Spain.

PLoS ONE, 2016
ObjectivesOur aim was to investigate if genetic variations in the visfatin gene (SNPs rs7789066/ rs11977021/rs4730153) could modify the cardiovascular-risk (CV-risk) despite the metabolic phenotype (obesity and glucose tolerance).
María Teresa Martínez Larrad, Arturo Corbatón Anchuelo, Cristina Fernández Pérez, Milagros Pérez Barba, Yera Lazcano Redondo, Manuel Serrano Ríos, Segovia Insulin Resistance Study Group (SIRSG)   +6 more
doaj   +1 more source

Inflammation, insulin resistance, and diabetes : mendelian randomization using CRP haplotypes points upstream [PDF]

, 2008
Background Raised C-reactive protein (CRP) is a risk factor for type 2 diabetes. According to the Mendelian randomization method, the association is likely to be causal if genetic variants that affect CRP level are associated with markers of diabetes ...
Timpson, NJ, Daniel R Witte, Kumari, Meena, Brunner, Eric J, Nicholas J Timpson, Witte Daniel R, Shah Tina, Kumari, M., Michelle Miller, Smith George Davey, Smith, GD, Humphries, SE, Smith, G.D., Aroon D Hingorani, Hingorani, AD, Marmot, MG, Rumley, A., Ann Rumley, Kumari Meena, Meena Kumari, Steve E Humphries, Michael G Marmot, Kumari, M, Witte, Daniel R, Shah, T, Casas, Juan P., Miller, M., Lowe, G.D., Marmot, Michael G, Juan P Casas, Rumley, Ann, Smith, George Davey, Shah, Tina, Humphries, S.E., Witte, DR, Gordon D O Lowe, Brunner Eric J, Lawlor, DA, Cooper Jackie A, Humphries Steve E, Cooper, J.A., Brunner, Eric, Hingorani, Aroon D, Marmot Michael G, Cooper, Jackie A., Miller, Michelle A., Lawlor, D.A., Witte, D.R., Timpson, Nicholas J., Lowe, GDO, Kivimäki, Mika, Casas Juan P, Mika Kivimäki, Cooper, Jackie A, Witte, Daniel R., Kivimaki, M., Kivimäki Mika, Miller, Michelle, Lawlor, Debbie A, Lowe, Gordon DO, Hingorani, A.D., Marmot, M.G., Humphries, Steve E, Tina Shah, Marmot, Michael G., Davey Smith, G, Lowe Gordon D. O, Brunner, EJ, Lowe, GD, Hingorani Aroon D, Cooper, JM, Lowe, G. D. O., Timpson, Nicholas J, Timpson Nicholas J, Brunner, E.J., Kivimaki, MJ, Lawlor, D, Casas, Juan P, Lawlor, Debbie A., Cooper, JA, Miller, M, Kivimaki, M, Eric J Brunner, Jackie A Cooper, Timpson, N.J., Debbie A Lawlor, Miller Michelle, Shah, T., Casas, JP, George Davey Smith, Rumley Ann, Casas, J.P., Rumley, A, Lawlor Debbie A, Humphries, Steve E., Hingorani, Aroon   +95 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source