Results 11 to 20 of about 281,999 (311)
TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21(Cip1) or Rb status [PDF]
, 2008 Melville Trust for the Care and Cure of Cancer to SP and SS.Background: TGF beta has pleiotropic effects that range from regulation of proliferation and apoptosis to morphological changes and epithelial-mesenchymal transition (EMT).
Sharon Sheahan +14 more
core +1 more source
Revista Española de Enfermedades Digestivas, 2019 We have read with great interest the study by Vera MC et al. on the intrasplenic transplantation of hepatocytes from donors receiving the carcinogenic drugs diethylnitrosamine (DEN) and 2-actylaminofluorene (2-AAF). The most important conclusion of the study is that there were no signs of tumor progression in the recipient liver at seven and 60 days ...
Javier A, Cienfuegos +2 more
openaire +2 more sources
Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro [PDF]
, 1993 Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation.
Kurtz, Armin +11 more
core +1 more source
Recent Advances in Models of Immune-Mediated Drug-Induced Liver Injury
Frontiers in Toxicology, 2021 Hepatic inflammation is a key feature of a variety of liver diseases including drug-induced liver injury (DILI), orchestrated by the innate immune response (Kupffer cells, monocytes, neutrophils, dendritic cells) and the adaptive immune system (T cells ...
Farah Tasnim +18 more
doaj +1 more source
Journal of Education, Health and Sport, 2021 Topicality. Comorbid course of alcoholic steatohepatitis (ASH) and non alcoholic steatohepatitis (NASH) with dysmetabolic iron overload syndrome (DIOS) is caused by the cascade of interload reactions, which may contribute to the progression of the ...
O. S. Khukhlina +2 more
doaj +1 more source
METABOLIC CHANGES IN HEPATOCYTES OF EXPERIMENTAL ANIMALS AFTER PROLONGED TREATMENT WITH SIMVASTATIN
Медицинский вестник Юга России, 2013 Purpose: To analyse the metabolic changes in the liver cells of experimental animals after prolonged treatment with simvastatin.Materials and Methods: Our experiment was taken on 40 rates (males) which were divided on two groups: 1-st (control) – 20 ...
Z. I. Mikashinovich +2 more
doaj +1 more source
In vitro biotransformation assays using fish liver cells: Comparing rainbow trout and carp hepatocytes. [PDF]
, 2022 Biotransformation assays using primary hepatocytes from rainbow trout, Oncorhynchus mykiss, were validated as a reliable in vitro tool to predict in vivo bioconcentration factors (BCF) of chemicals in fish.
Segner, Helmut +7 more
core +1 more source
Cell Reports, 2021 Summary: Chronic injury to hepatocytes results in inflammation, steatohepatitis, fibrosis, and nonalcoholic fatty liver disease (NAFLD). The tetraspanin TM4SF5 is implicated in fibrosis and cancer.
Eunmi Kim +10 more
doaj +1 more source
Hepatocyte Transplantation [PDF]
Journal of Clinical and Experimental Hepatology, 2011 Hepatocyte transplantation (HTx) has been developed for use in liver-based metabolic disorders and in acute liver failure. Worldwide, there are around 80 patients that have been transplanted with hepatocytes. Almost all reported studies prove feasibility and safety of the procedure with short- to medium-term success.
Ragai R, Mitry +2 more
openaire +2 more sources
Mechanisms of transcriptional control of glucose metabolism in hepatocytes
Сахарный диабет, 2016 The hepatic tissue plays a key role in the regulation and maintenance of stable blood glucose levels. The liver is the main gluconeogenesis organ of the body and is under constant hormonal control to determine the metabolic activity of hepatocytes ...
Konstantin Y. Kulebyakin +3 more
doaj +1 more source