Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsis [PDF]
Nature CommunicationsSepsis-induced liver injury is common, but the underlying mechanisms remain poorly understood. Given the critical role of gut-liver crosstalk in sepsis, we hypothesize that gut-trained neutrophils, migrating via the portal vein, release neutrophil ...
Atsushi Murao +6 more
doaj +2 more sources
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche [PDF]
Immunity, 2019 Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific identities of macrophages in their respective niches. Using conditional depletion of liver Kupffer cells,
Johnny Bonnardel +2 more
exaly +3 more sources
Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy. [PDF]
PLoS ONE, 2015 TNF and Fas/FasL are vital components, not only in hepatocyte injury, but are also required for hepatocyte regeneration. Liver F4/80+Kupffer cells are classified into two subsets; resident radio-resistant CD68+cells with phagocytic and bactericidal ...
Kiyoshi Nishiyama +7 more
doaj +3 more sources
A broadly adaptable protocol for isolating Kupffer cells from non-model species: application to Mastomys natalensis and its susceptibility to Old World mammarenaviruses [PDF]
Frontiers in ImmunologyBackgroundKupffer cells are specialized, liver-resident macrophages that play central roles in hepatic homeostasis, immune surveillance and pathogen clearance.
Nicolas Corrales +3 more
doaj +2 more sources
Kupffer cells determine intrahepatic traffic of PEGylated liposomal doxorubicin [PDF]
Nature CommunicationsIntrahepatic accumulation dominates organ distribution for most nanomedicines. However, obscure intrahepatic fate largely hampers regulation on their in vivo performance.
Kuan Jiang +7 more
doaj +2 more sources
Induction of Th1Immune responses following laser ablation in a murine model of colorectal liver metastases [PDF]
Journal of Translational Medicine, 2011 Background Preliminary experimental studies have suggested that the in situ destruction of tumor tissue by local laser ablation (LA) may also stimulate host immunity against cancer.
Muralidharan Vijayaragavan +6 more
doaj +5 more sources
STAR Protocols, 2022 Summary: Kupffer cells play critical roles in both hepatitis B virus (HBV) persistence and clearance. Here, we provide a protocol for studying the interplay between Kupffer cells and HBV-positive hepatocytes ex vivo using mice as a model.
Yumei Li +4 more
doaj +1 more source
Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death. [PDF]
PLoS ONE, 2013 BACKGROUND: Dietary lipids play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) through alternation of liver innate immune response.
Tongfang Tang +4 more
doaj +1 more source
Involvement of the TNF and FasL produced by CD11b Kupffer cells/macrophages in CCl4-induced acute hepatic injury. [PDF]
PLoS ONE, 2014 We previously reported that F4/80(+) Kupffer cells are subclassified into CD68(+) Kupffer cells with phagocytic and ROS producing capacity, and CD11b(+) Kupffer cells with cytokine-producing capacity. Carbon tetrachloride (CCl4)-induced hepatic injury is
Atsushi Sato +6 more
doaj +1 more source
Epigenetic Regulation of Kupffer Cell Function in Health and Disease
Frontiers in Immunology, 2021 Kupffer cells, the resident macrophages of the liver, comprise the largest pool of tissue macrophages in the body. Within the liver sinusoids Kupffer cells perform functions common across many tissue macrophages including response to tissue damage and ...
Hunter Bennett +5 more
doaj +1 more source