Results 21 to 30 of about 45,372 (255)

PM2.5 exposure aggravates acute liver injury by creating an inflammatory microenvironment through Kupffer cell

Ecotoxicology and Environmental Safety, 2023
Aim: This work aimed to investigate the impact of PM2.5 exposure on acute liver injury Methods: C57BL/6 mice were used to examine the hepatic histopathological changes in PM2.5-exposed mice, as well as in CCl4-mediated acute liver injury mice after long ...
Hongyan Pei, Zhongmei He, Rui Du, Yu Zhu, Yi Yang   +4 more
doaj   +1 more source

c-Myb Dominates TBK1-Mediated Endotoxin Tolerance in Kupffer Cells by Negatively Regulating DTX4

Journal of Immunology Research, 2023
As a protective mechanism regulating excessive inflammation, endotoxin tolerance plays a vital role in regulating endotoxin shock. Kupffer cells are players in mediating endotoxin tolerance.
Yi-Lin Wu, Le-Han Pan, Zhu-Jun Yi, Wen-Feng Zhang, Jian-Ping Gong   +4 more
doaj   +1 more source

The Antidepressant Mirtazapine Activates Hepatic Macrophages, Facilitating Pathogen Clearance While Limiting Tissue Damage in Mice

Frontiers in Immunology, 2020
Background and AimsMirtazapine is an atypical antidepressant with antagonist activity for serotonin and histamine receptors. Clinical and experimental evidence suggests that, in addition to treating depression, mirtazapine also alters liver innate ...
Rachelle Paige Davis, Rachelle Paige Davis, Wagdi Almishri, Wagdi Almishri, Craig Neal Jenne, Craig Neal Jenne, Mark Gordon Swain, Mark Gordon Swain   +7 more
doaj   +1 more source

CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis. [PDF]

PLoS ONE, 2013
CD2-like receptor activating cytotoxic cells (CRACC) is known as a critical activating receptor of natural killer (NK) cells. We have previously reported that NK cells contribute to Poly I:C/D-galactosamine (D-GalN)-induced fulminant hepatitis.
Yangxi Li, Guoshuai Cao, Xiaodong Zheng, Jun Wang, Haiming Wei, Zhigang Tian, Rui Sun   +6 more
doaj   +1 more source

A Novel Function of Mitochondrial Phosphoenolpyruvate Carboxykinase as a Regulator of Inflammatory Response in Kupffer Cells

Frontiers in Cell and Developmental Biology, 2021
Background: There has been a recent appreciation that some metabolic enzymes can profoundly influence the nature of the immune response produced in macrophages.
Haibo Dong, Haibo Dong, Yue Feng, Yue Feng, Yang Yang, Yang Yang, Yun Hu, Yun Hu, Yimin Jia, Yimin Jia, Shu Yang, Shu Yang, Nannan Zhao, Nannan Zhao, Ruqian Zhao, Ruqian Zhao   +15 more
doaj   +1 more source

Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis

Frontiers in Immunology
IntroductionSepsis is a life-threatening inflammatory condition caused by dysregulated host responses to infection. Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently discovered damage-associated molecular pattern that causes ...
Junji Shimizu, Atsushi Murao, Yongchan Lee, Monowar Aziz, Monowar Aziz, Ping Wang, Ping Wang   +6 more
doaj   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure

Frontiers in Cell and Developmental Biology, 2021
Here, we studied the metabolic function of LAMTOR1 from macrophages using LAMTOR1 macrophage-specific knockout (MKO) mice. LAMTOR1 MKO mice showed resistance to high-fat diet (HFD)-induced obesity, lipid steatosis, and glucose metabolic disorders, with ...
Lingwen Ying, Mingliang Zhang, Xiaojing Ma, Yiming Si, Xiaoya Li, Jiaorong Su, Jun Yin, Jun Yin, Yuqian Bao   +8 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Inhibition of Kupffer Cell Activity Improves Transplantation of Human Adipose-Derived Stem Cells and Liver Functions

Cell Transplantation, 2013
Numerous approaches to cell transplantation of the hepatic or the extrahepatic origin into liver tissue have been developed; however, the efficiency of cell transplantation remains low and liver functions are not well corrected.
Il-Hwa Hong, Seon-Young Han, Mi-Ran Ki, Young-Mi Moon, Jin-Kyu Park, Sang-Young You, Eun-Mi Lee, Ah-Young Kim, Eun-Joo Lee, Jae-Ho Jeong, Kyung-Sun Kang, Kyu-Shik Jeong D.V.M., Ph.D.   +11 more
doaj   +1 more source