Results 21 to 30 of about 74,691 (293)

MicroRNA-223 Acts as an Important Regulator to Kupffer Cells Activation at the Early Stage of Con A-Induced Acute Liver Failure via AIM2 Signaling Pathway

Cellular Physiology and Biochemistry, 2014
Background: Acute liver failure (ALF), known as a rapid and severe clinical syndrome, can induce multiple organ dysfunction and failure. It was noticed that Kupffer cells activation at the initial phase was involved in some intense inflammatory responses
Fan Yang, Guohua Lou, Xiaotang Zhou, Min Zheng, Jiliang He, Zhi Chen   +5 more
doaj   +1 more source

The Presence of Vacuolated Kupffer Cells Raises a Clinical Suspicion of Niemann-Pick Disease Type C in Neonatal Cholestasis

Frontiers in Genetics, 2022
Early diagnosis of Niemann-Pick disease type C (NP-C) in neonatal cholestasis is still challenging because splenomegaly is non-specific and oxysterol profiling studies also have a relatively low specificity.
Neng-Li Wang, Lian Chen, Yi Lu, Xin-Bao Xie, Jing Lin, Kuerbanjiang Abuduxikuer, Jian-She Wang   +6 more
doaj   +1 more source

Intestinal fungi contribute to development of alcoholic liver disease [PDF]

, 2017
This study was supported in part by NIH grants R01 AA020703, U01 AA021856 and by Award Number I01BX002213 from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development (to B.S.). K.H.
Ali Keshavarzian, An-Ming Yang, Bernd Schnabl, Bode, Chien-Sheng Chen, Claus Hellerbrand, Cristina Llorente, Derrick E. Fouts, Ece A. Mutlu, Fettweis, Fouts, Gordon D. Brown, Guadalupe Garcia-Tsao, Hal M. Hoffman, Jun Xu, Karen Beeri, Katrin Hochrath, Kelvin Moncera, Kim Freese, Lee, Lirui Wang, Liu, Manolito G. Torralba, Peng Chen, Peter Stärkel, Phillipp Hartmann, Ramon Bataller, Samuel B. Ho, Sena Bluemel, Serene M.L. Lee, Sokol, Tatiana Kisseleva, Tatsuo Inamine, Wagner, Wajahat Z. Mehal, Yamahiro, Yang, Yukinori Koyama   +37 more
core   +3 more sources

Glutathione treatment protects the rat liver against injury after warm ischemia and Kupffer cell activation [PDF]

, 2002
Background/Aim: The generation of reactive oxygen species by activated Kupffer cells (KC) may contribute to reperfusion injury of the liver during liver transplantation or resection.
Baron, A., Bilzer, M., Ebensberger, S., Gerbes, Alexander L., Schauer, R., Steib, C.   +5 more
core   +1 more source

Demonstration of glucose-6-phosphate dehydrogenase in rat Kupffer cells by a newly-developed ultrastructural enzyme-cytochemistry

European Journal of Histochemistry, 2009
Although various tissue macrophages possess high glucose- 6-phosphate dehydrogenase (G6PD) activity, which is reported to be closely associated with their phagocytotic/bactericidal function, the fine subcellular localization of this enzyme in liver ...
S Matsubara, D Matsubara, T Ishibashi, T Takizawa   +3 more
doaj   +1 more source

PM2.5 exposure aggravates acute liver injury by creating an inflammatory microenvironment through Kupffer cell

Ecotoxicology and Environmental Safety, 2023
Aim: This work aimed to investigate the impact of PM2.5 exposure on acute liver injury Methods: C57BL/6 mice were used to examine the hepatic histopathological changes in PM2.5-exposed mice, as well as in CCl4-mediated acute liver injury mice after long ...
Hongyan Pei, Zhongmei He, Rui Du, Yu Zhu, Yi Yang   +4 more
doaj   +1 more source

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. [PDF]

, 2014
The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of ...
Bandyopadhyay, Gautam, Bogner-Strauss, Juliane G, Chi, Tyler J, Chung, Heekyung, Evans, Ronald M, Franck, Niclas, Hah, Nasun, Heinrichsdorff, Jan, Mayoral, Rafael, Morinaga, Hidetaka, Oh, Da Young, Olefsky, Jerrold M, Osborn, Olivia, Pessentheiner, Ariane R, Walenta, Evelyn   +14 more
core   +2 more sources

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy [PDF]

, 2013
AIM: To investigate the pathogenesis of non-alcoholic fatty liver disease (NAFLD) after pancreatoduodenectomy (PD). METHODS: A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the ...
Fujiwara, Toshiyoshi, Nagasaka, Takeshi, Sadamori, Hiroshi, Satoh, Daisuke, Shinoura, Susumu, Tanaka, Takehiro, Umeda, Yuzo, Utsumi, Masashi, Yagi, Takahito, Yoshida, Ryuichi   +9 more
core   +1 more source

Kupffer cells in hepatotoxicity

EXCLI journal, 2020
EXCLI Journal; 19:Doc1156; ISSN 1611 ...
openaire   +3 more sources