Results 41 to 50 of about 411,384 (307)

Hepatitis C, Innate Immunity and Alcohol: Friends or Foes?

Biomolecules, 2015
Hepatitis C and alcohol are the most widespread causes of liver disease worldwide. Approximately 80% of patients with a history of hepatitis C and alcohol abuse develop chronic liver injury.
Natalia A. Osna, Murali Ganesan, Kusum K. Kharbanda   +2 more
doaj   +1 more source

Inhibitory Effect of IL-1β on HBV and HDV Replication and HBs Antigen-Dependent Modulation of Its Secretion by Macrophages

Viruses, 2021
Co-infection with the hepatitis B virus and hepatitis delta virus (HDV) leads to the most aggressive form of viral hepatitis. Using in vitro infection models, we confirmed that IL-1β, a crucial innate immune molecule for pathogen control, was very potent
Marion Delphin, Suzanne Faure-Dupuy, Nathalie Isorce, Michel Rivoire, Anna Salvetti, David Durantel, Julie Lucifora   +6 more
doaj   +1 more source

IGFBP-5 as a biomarker of de-differentiation in hepatocytes [PDF]

, 2011
Describes IGFBP-5 as a biomarker of de-differentiation in hepatocytes presented at the 47th Congress of the European-Societies-of ...
Flint, David, Grant, Mary, Henderson, Catherine, Large, Emma   +3 more
core   +1 more source

Hepatocyte Differentiation [PDF]

, 2010
Increasingly, research suggests that for certain systems, animal models are insufficient for human toxicology testing. The development of robust, in vitro models of human toxicity is required to decrease our dependence on potentially misleading in vivo animal studies.
Katy M, Olsavsky Goyak, Elizabeth M, Laurenzana, Curtis J, Omiecinski   +2 more
openaire   +2 more sources

Effect of Thermal Stress on Caprine Hepatocyte’s Antioxidant Enzymes Activity and TGF β Secretion In Vitro [PDF]

Journal of Stress Physiology & Biochemistry, 2014
Liver is involved in several vital functions such as synthesis, secretion, storage and metabolism of plasma proteins and in detoxifying functions. In the present study, hepatocytes were obtained by disaggregation of caprine liver caudate lobe.
Phad Ashok Vyankati, Anand Laxmi
doaj  

Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy

Journal of Lipid Research, 2006
Scavenger receptor class B type I (SR-BI) plays a critical role in the delivery of HDL cholesterol and cholesteryl esters (CEs) to liver and steroidogenic tissues by a selective process that does not result in significant degradation of HDL protein ...
Chris J. Harder, Gerard Vassiliou, Heidi M. McBride, Ruth McPherson   +3 more
doaj   +1 more source

Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured?

Cells, 2021
Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells, activation of different immune cells and signaling pathways, as well as a ...
Arshi Khanam, Paul G. Saleeb, Shyam Kottilil   +2 more
doaj   +1 more source

Layered Long Term Co-Culture of Hepatocytes and Endothelial Cells on a Transwell Membrane: Toward Engineering the Liver Sinusoid

, 2013
This paper presents a novel liver model that mimics the liver sinusoid where most liver activities occur. A key aspect of our current liver model is a layered co-culture of primary rat hepatocytes (PRHs) and primary rat liver sinusoidal endothelial cells
Bouchard, Michael, Cirillo, Joseph, Kang, Young Bok (Abraham), Noh, Hongseok (Moses), Rawat, Siddhartha   +4 more
core   +1 more source

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression [PDF]

, 2018
The complete mechanism accounting for the progression from simple steatosis to steatohepatitis in nonalcoholic fatty liver disease (NAFLD) has not been elucidated.
Avolio, Carlo, Bellanti, Francesco, Blonda, Maria, di Bello, Giorgia, Facciorusso, Antonio, Iannelli, Giuseppina, Iuliano, Luigi, Poli, Giuseppe, Serviddio, Gaetano, Tamborra, Rosanna, Vendemiale, Gianluigi, Villani, Rosanna   +11 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source