Results 61 to 70 of about 281,999 (311)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

PPAR-mediated reduction of lipid accumulation in hepatocytes involves the autophagy-lysosome-mitochondrion axis

Annals of Medicine
Background and aim Lipid accumulation in hepatocytes is reduced by the activation of the peroxisome proliferator-activated receptor (PPAR) α, which is associated with increased lysosomal acid lipase (LAL) activity, transcription factor EB (TFEB ...
Federica Cetti, Alice Ossoli, Carola Garavaglia, Lorenzo Da Dalt, Giuseppe Danilo Norata, Monica Gomaraschi   +5 more
doaj   +1 more source

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice

Frontiers in Pharmacology, 2018
Background and Aim: To investigate whether double-knockdown of PHD1 and Keap1 in mice could enhance the resolution of carbon tetrachloride (CCl4)-induced liver fibrosis.Methods: The liver fibrosis model of mice was established by intraperitoneal ...
Jing Liu, Wencai Li, Manoj H. Limbu, Yiping Li, Zhi Wang, Zhengyuan Cheng, Xiaoyi Zhang, Pingsheng Chen   +7 more
doaj   +1 more source

The Influence of Coumestrol on Sphingolipid Signaling Pathway and Insulin Resistance Development in Primary Rat Hepatocytes

Biomolecules, 2021
Coumestrol is a phytoestrogen widely known for its anti-diabetic, anti-oxidant, and anti-inflammatory properties. Thus, it gets a lot of attention as a potential agent in the nutritional therapy of diseases such as obesity and type 2 diabetes.
Hubert Zywno, Wiktor Bzdega, Adrian Kolakowski, Piotr Kurzyna, Ewa Harasim-Symbor, Klaudia Sztolsztener, Adrian Chabowski, Karolina Konstantynowicz-Nowicka   +7 more
doaj   +1 more source

Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

, 2009
Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver.
Rakhshandehroo, M., Kersten, A.H., Müller, Michael, Müller Michael, Maryam Rakhshandehroo, Hooiveld Guido, Sander Kersten, Michael Müller, Guido Hooiveld, Müller, M.R., Kersten Sander, Rakhshandehroo, Maryam, Hooiveld, Guido, Hooiveld, G.J.E.J., Rakhshandehroo Maryam, Kersten, Sander   +15 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

The stem and progenitor cells and the functional activity of liver from age-different Wistar rats

Сибирский научный медицинский журнал
The liver has a big potential for self-healing, but the activity of regeneration decreases with age. Changes are occurring, including in the functional activity of various liver cell populations, the study of the characteristics of which can become the ...
O. V. Pershina, I. A. Uzyanbaev, A. V. Pakhomova, E. S. Pan, L. V. Kogay, N. N. Ermakova, L. A. Sandrikina, B. K. Kurbatov, V. A. Krupin   +8 more
doaj   +1 more source

Hexanoic, Octanoic and Decanoic Acids Promote Basal and Insulin-Induced Phosphorylation of the Akt-mTOR Axis and a Balanced Lipid Metabolism in the HepG2 Hepatoma Cell Line

Molecules, 2018
Metabolic illnesses such as non-alcoholic fatty liver disease (NAFLD) are in constant increase worldwide. Highly consumed long chain fatty acids (LCFA) are among the most obesogenic and steatogenic nutrients.
Sabri Ahmed Rial, Gaetan Ravaut, Tommy B. Malaret, Karl-F. Bergeron, Catherine Mounier   +4 more
doaj   +1 more source

Tri-Herbal Medicine Divya Sarva-Kalp-Kwath (Livogrit) Regulates Fatty Acid-Induced Steatosis in Human HepG2 Cells through Inhibition of Intracellular Triglycerides and Extracellular Glycerol Levels

Molecules, 2020
Steatosis is characterized by excessive triglycerides accumulation in liver cells. Recently, application of herbal formulations has gained importance in treating complex diseases.
Acharya Balkrishna, Vivek Gohel, Rani Singh, Monali Joshi, Yash Varshney, Jyotish Srivastava, Kunal Bhattacharya, Anurag Varshney   +7 more
doaj   +1 more source

Aging-Related Changes in the Ultrastructure of Hepatocytes and Cardiomyocytes of Elderly Mice Are Enhanced in ApoE-Deficient Animals

Cells, 2021
Biological aging is associated with various morphological and functional changes, yet the mechanisms of these phenomena remain unclear in many tissues and organs. Hyperlipidemia is among the factors putatively involved in the aging of the liver and heart.
Małgorzata Łysek-Gładysińska, Anna Wieczorek, Artur Jóźwik, Anna Walaszczyk, Karol Jelonek, Grażyna Szczukiewicz-Markowska, Olaf K. Horbańczuk, Monika Pietrowska, Piotr Widłak, Dorota Gabryś   +9 more
doaj   +1 more source