Results 81 to 90 of about 281,999 (311)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview

Cells, 2019
Fibrosis is a common feature in most pathogenetic processes in the liver, and usually results from a chronic insult that depletes the regenerative capacity of hepatocytes and activates multiple inflammatory pathways, recruiting resident and circulating ...
Daphne Pinheiro, Isabelle Dias, Karina Ribeiro Silva, Ana Carolina Stumbo, Alessandra Thole, Erika Cortez, Lais de Carvalho, Ralf Weiskirchen, Simone Carvalho   +8 more
doaj   +1 more source

THE ROLE OF INFLAMMASOME AND CASPASE-1 IN REGULATING ADAPTIVE RESPONSE TO OXIDATIVE STRESS IN MOUSE HEPATOCYTES [PDF]

, 2013
In myeloid cells, oxidative stress can induce the activation of caspase-1 through canonical inflammasome signaling, which leads to the release of proinflammatory cytokines IL-1β/IL-18 and a potentially damaging inflammatory response.
Sun, Qian
core  

Primary cultured cells as sensitive in vitro model for assessment of toxicants-comparison to hepatocytes and gill epithelia

, 2006
In an effort to develop cultured cell models for toxicity screening and environmental biomonitoring, we compared primary cultured gill epithelia and hepatocytes from freshwater tilapia (Oreochromis niloticus) to assess their sensitivity to AhR agonist ...
Zhou, Bingsheng, Wang, Jingxian, Wu, Rudolf S. S., Liu, Chunsheng, Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Lam, Paul K. S.   +5 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification

Epigenetics, 2017
Patterns of DNA methylation (5-methylcytosine, 5mC) are rearranged during differentiation contributing to the regulation of cell type-specific gene expression.
Lara C. Lewis, Peggy Cho Kiu Lo, Jeremy M. Foster, Nan Dai, Ivan R. Corrêa, Paulina M. Durczak, Gary Duncan, Ashley Ramsawhook, Guruprasad Padur Aithal, Chris Denning, Nicholas R. F. Hannan, Alexey Ruzov   +11 more
doaj   +1 more source

Microfibrous extracellular matrix enhances in vitro modeling of the liver hepatocytes by modulating metabolism and integrin expression

, 2020
A microfibrous ECM fabricated by electrospinning silk fibroin can modulate the energy metabolism, amino acids bioavailability, and integrins expression in hepatocytes, making the cells more physiologically ...
Chengpeng, Chen, Tianjiao, Huang, Jay H., Chung, Curtis G., Jones   +3 more
core   +1 more source

Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase [PDF]

, 2011
Background Plasmodium falciparum sporozoites injected by mosquitoes into the blood rapidly enter liver hepatocytes and undergo pre-erythrocytic developmental schizogony forming tens of thousands of merozoites per hepatocyte.
Piacentini Mauro, Rodolfo, Carlo, Giuseppina Di Giacomo, Doerig Christian, Di Giacomo, Giuseppina, Piacentini, Mauro, Lanar David E, William S Nicoll, Di Giacomo, G, Nicoll, W.S., Doerig, C., Hollingdale, M.R., David E Lanar, Sacci, JB, Sacci, John, John B Sacci, Piacentini, M, Zoe JM Holland, Michael R Hollingdale, Rodolfo, C., Lanar, D.E., Nicoll William S, Mauro Piacentini, Sacci John B, Doerig, Christian, Lanar, DE, Sacci, J.B., Hollingdale Michael R, Rodolfo Carlo, Hollingdale, MR, Rodolfo, C, Holland, Zoe, Lanar, David, Christian Doerig, Holland Zoe JM, Holland, Z.J.M., Carlo Rodolfo, Di Giacomo Giuseppina, Holland, ZJ, Nicoll, William, Nicoll, WS, Doerig, C, Hollingdale, Michael   +42 more
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source