Results 31 to 40 of about 281,999 (311)

The sensitivity of cells with the various level of NAD(P)H:quinone oxidoreductase 1 to cytotoxic action of quinonimines and α-тоcopherol synthetic derivatives [PDF]

The Ukrainian Biochemical Journal, 2015
The effects of α-tocopherol with shortened to 6 carbon atoms side chain (α-Toc-C6), α-tocopherol succinate (α-TS) and quinonimine 2,6-dichlorophenolindophenol (DCPIP) on DT-diaphorase activity and viability of rat thymocytes, splenocytes and hepatocytes ...
G. V. Petrova, А. V. Parshykov
doaj   +1 more source

Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.)

, 2013
Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the ...
Ekstrand, Bo, Klausen, Christina Lindgaard, Rasmussen, Martin Krøyer   +2 more
core   +1 more source

Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis [PDF]

, 2013
Particularly interesting new cysteine-histidine-rich protein (PINCH) protein is part of the ternary complex known as the IPP (integrin linked kinase (ILK)-PINCH-Parvin-α) complex.
Bhave, VS, Haynes, MM, Donthamsetty, Shashikiran, George K Michalopoulos, Shashikiran Donthamsetty, Meagan M Haynes, Mars, WM, Orr, A, Haynes, Meagan M., Bowen, WC, Anne Orr, Chuanyue Wu, Wu, Chuanyue, Orr, Anne, William C Bowen, Wu, C, Singh, Shree Ram, Vishakha S Bhave, Wendy M Mars, Bhave, Vishakha S., Michalopoulos, George K., Bhave, Vishakha, Donthamsetty, S, Mars, Wendy M., Michalopoulos, GK, Bowen, William C.   +25 more
core   +1 more source

Liver Cell Mitophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis

Antioxidants
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of the global population. MASLD and its advanced-stage liver fibrosis and cirrhosis are the leading causes of liver failure and liver-related death worldwide.
Jiaxin Chen, Linge Jian, Yangkun Guo, Chengwei Tang, Zhiyin Huang, Jinhang Gao   +5 more
doaj   +1 more source

Hepatitis C, Innate Immunity and Alcohol: Friends or Foes?

Biomolecules, 2015
Hepatitis C and alcohol are the most widespread causes of liver disease worldwide. Approximately 80% of patients with a history of hepatitis C and alcohol abuse develop chronic liver injury.
Natalia A. Osna, Murali Ganesan, Kusum K. Kharbanda   +2 more
doaj   +1 more source

Inhibitory Effect of IL-1β on HBV and HDV Replication and HBs Antigen-Dependent Modulation of Its Secretion by Macrophages

Viruses, 2021
Co-infection with the hepatitis B virus and hepatitis delta virus (HDV) leads to the most aggressive form of viral hepatitis. Using in vitro infection models, we confirmed that IL-1β, a crucial innate immune molecule for pathogen control, was very potent
Marion Delphin, Suzanne Faure-Dupuy, Nathalie Isorce, Michel Rivoire, Anna Salvetti, David Durantel, Julie Lucifora   +6 more
doaj   +1 more source

Hepatocyte Differentiation [PDF]

, 2010
Increasingly, research suggests that for certain systems, animal models are insufficient for human toxicology testing. The development of robust, in vitro models of human toxicity is required to decrease our dependence on potentially misleading in vivo animal studies.
Katy M, Olsavsky Goyak, Elizabeth M, Laurenzana, Curtis J, Omiecinski   +2 more
openaire   +2 more sources

Effect of Thermal Stress on Caprine Hepatocyte’s Antioxidant Enzymes Activity and TGF β Secretion In Vitro [PDF]

Journal of Stress Physiology & Biochemistry, 2014
Liver is involved in several vital functions such as synthesis, secretion, storage and metabolism of plasma proteins and in detoxifying functions. In the present study, hepatocytes were obtained by disaggregation of caprine liver caudate lobe.
Phad Ashok Vyankati, Anand Laxmi
doaj  

Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy

Journal of Lipid Research, 2006
Scavenger receptor class B type I (SR-BI) plays a critical role in the delivery of HDL cholesterol and cholesteryl esters (CEs) to liver and steroidogenic tissues by a selective process that does not result in significant degradation of HDL protein ...
Chris J. Harder, Gerard Vassiliou, Heidi M. McBride, Ruth McPherson   +3 more
doaj   +1 more source

Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured?

Cells, 2021
Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells, activation of different immune cells and signaling pathways, as well as a ...
Arshi Khanam, Paul G. Saleeb, Shyam Kottilil   +2 more
doaj   +1 more source