Results 31 to 40 of about 233,279 (266)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
CellsInsulin resistance (IR) disrupts hepatic glucose metabolism and mitochondrial function, which contributes to metabolic disorders. The present study examined the effects of tomatine on glucose metabolism in high-glucose-induced IR hepatocytes and explored
Yu Geon Lee, Donghwan Kim
doaj +1 more source
Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1
Journal of Lipid Research, 2003 ATP binding cassette transporter A1 (ABCA1) is a widely expressed lipid transporter essential for the generation of HDL. ABCA1 is particularly abundant in the liver, suggesting that the liver may play a major role in HDL homeostasis.
Cheryl L. Wellington +14 more
doaj +1 more source
Biosensors, 2021 The perfusion culture of primary hepatocytes has been widely adopted to build bioreactors for various applications. As a drug testing platform, a unique vertical-flow bioreactor (VfB) array was found to create the compaction culture of hepatocytes which ...
Liang Zhu +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
A surprising new hiding place for a dangerous pathogen
eLifeThe bacterium that causes TB can hide in liver cells called hepatocytes, and reprogram their metabolism for its own benefit.
Sheetal Gandotra, Yogendra Singh
doaj +1 more source
Uptake of long-chain fatty acids in HepG2 cells involves caveolae
Journal of Lipid Research, 2002 We investigated the role of caveolae in uptake and intracellular trafficking of long chain fatty acids (LCFA) in HepG2 human hepatoma cells. The uptake of [3H]oleic acid and [3H]stearic acid into HepG2 cells was measured by radioactive assays and ...
Jürgen Pohl +2 more
doaj +1 more source
Bioengineering, 2022 To use hepatocytes immediately when necessary for hepatocyte transplantation and bioartificial liver (BAL) systems, a serum-free cryopreservation protocol ensuring the high survival of hepatocytes and maintenance of their functions should be developed ...
Ji-Hyun Lee +8 more
doaj +1 more source
Hepatocyte Differentiation [PDF]
, 2010 Increasingly, research suggests that for certain systems, animal models are insufficient for human toxicology testing. The development of robust, in vitro models of human toxicity is required to decrease our dependence on potentially misleading in vivo animal studies.
Katy M, Olsavsky Goyak +2 more
openaire +2 more sources