Results 21 to 30 of about 20,962,508 (350)

Dusp1 modulates activin/smad2 mediated germ layer specification via FGF signal inhibition in Xenopus embryos

Animal Cells and Systems, 2020
Activin, a member of the transforming growth factor (TGF-β) superfamily, induces mesoderm, endoderm and neuro-ectoderm formation in Xenopus embryos. Despite several previous studies, the complicated gene regulatory network and genes involved in this ...
Zobia Umair, Santosh Kumar, Khezina Rafiq, Vijay Kumar, Zia Ur Reman, Seung-Hwan Lee, SungChan Kim, Jae-Yong Lee, Unjoo Lee, Jaebong Kim   +9 more
doaj   +1 more source

Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls

Scientific Reports, 2023
Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting chemicals (EDCs) are active substances that interfere with hormonal signaling. Among EDCs,
Andrea Di Credico, Amélie Weiss, Massimo Corsini, Giulia Gaggi, Barbara Ghinassi, Johannes H. Wilbertz, Angela Di Baldassarre   +6 more
doaj   +1 more source

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells [PDF]

, 2015
© 2015 Macmillan Publishers Limited. All rights reserved. microRNA-34a (miR-34a) and sirtuin 1 (SirT1) have been extensively studied in tumour biology and longevityaging, but little is known about their functional roles in smooth muscle cell (SMC ...
L A Luong, Wen, G., Q Chen, Luong, LA, Q Xiao, Zhu, J, Zhu, J., Chen, Q, Y Huang, Luong, L. A., Zhang, L., Ye, S., H Zhao, G Wen, Wang, W, L Zhang, Xu, Q., Yu, X., Wen, G, Xiao, Q, Ye, S, Huang, Y, Q Xu, Zhao, H, X Yu, Huang, Y., Xu, Q, W Wang, Chen, Q., J Zhu, Yu, X, Zhang, L, Wang, W., Xiao, Q., Zhao, H., S Ye   +35 more
core   +1 more source

DNA methylation dynamics in the rat EGF gene promoter after partial hepatectomy

Genetics and Molecular Biology, 2014
Epidermal growth factor (EGF), a multifunctional growth factor, is a regulator in a wide variety of physiological processes. EGF plays an important role in the regulation of liver regeneration.
Deming Li, Jinyu Fan, Ziwei Li, Cunshuan Xu   +3 more
doaj   +1 more source

Bile acid metabolites control Th17 and Treg cell differentiation

Nature, 2018
Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is ...
Sai-Yu Hang, Donggi Paik, Li-Na Yao, Eunha Kim, Trinath Jamma, Jingping Lu, Soyoung Ha, Brandon N. Nelson, Samantha P. Kelly, Lin Wu, Ye Zheng, R. Longman, F. Rastinejad, A. Devlin, M. R. Krout, M. Fischbach, D. Littman, Jun R. Huh   +17 more
semanticscholar   +1 more source

Slow Turning Lateral Vessel Bioreactor Improves Embryoid Body Formation and Cardiogenic Differentiation of Mouse Embryonic Stem Cells. [PDF]

, 2013
Embryonic stem cells (ESCs) have the ability to form aggregates, which are called embryoid bodies (EBs). EBs mimic early embryonic development and are commonly produced for cardiomyogenesis.
Tharasanit, T., Biology of Reproductive Cells, Pirity, M., Rungarunlert, Sasitorn, Klincumhom, Nuttha, Rungarunlert, S., Dinnyés, András, Tharasanit, Theerawat, Dep Gezondheidszorg Landbouwhuisdieren, Klincumhom, N., Techakumphu, M., Pirity, Melinda, Dinnyes, A.   +12 more
core   +1 more source

Delayed Liver Regeneration after Partial Hepatectomy in Aged Nos2 Knockout Mice

Cell Journal, 2017
Objective Patients over 60 years of age have higher mortality and morbidity after major liver resections. Nitric oxide (NO) derived from the catalytic activity of Nos2 plays a beneficial role in liver regeneration (LR) after partial hepatectomy (PH). In
Deming Li, Jun Li, Gaiping Wang, Yanli Qin, Zhipeng Niu, Ziwei Li, Cunshuan Xu   +6 more
doaj   +1 more source

Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification

Cancer Biology & Therapy, 2023
The possible anticancer activity of combination (M + E + F) of metformin (M), efavirenz (E), and fluoxetine (F) was investigated in normal HDF cells and HCT116 human colon cancer cells.
Beom-Goo Kang, Madhuri Shende, Gozde Inci, Soo-Hyun Park, Jun-Sub Jung, Set Byeol Kim, Jeong Hoon Kim, Young Won Mo, Ji-Hyeon Seo, Jing-Hui Feng, Sung-Chan Kim, Soon Sung Lim, Hong-Won Suh, Jae-Yong Lee   +13 more
doaj   +1 more source

Dendritic Cell Differentiation [PDF]

The Journal of Immunology, 2004
Dauer et al. ([1][1]) presented a method to differentiate CD14+ cells into mature dendritic cells (DC) within 48 h (FastDC). FastDC displayed a DC-like morphology, down-regulated CD14, and induced proliferation of autologous T cells against soluble Ags as efficiently as standard monocyte-derived ...
Curti A, Ferri E, Pandolfi S, Isidori A, LEMOLI, ROBERTO MASSIMO   +4 more
openaire   +4 more sources

Regulating T cell differentiation through the polyamine spermidine.

Journal of Allergy and Clinical Immunology, 2020
BACKGROUND The cross-talk between the host and its microbiota plays a key role in the promotion of health. The production of metabolites, such as polyamines, by intestinal-resident bacteria is part of this symbiosis shaping host immunity.
Guilhermina M. Carriche, Luís Almeida, Philipp Stüve, L. Velasquez, Ayesha Dhillon-LaBrooy, Urmi Roy, M. Lindenberg, T. Strowig, Carlos Plaza-Sirvent, I. Schmitz, M. Lochner, A. Simon, T. Sparwasser   +12 more
semanticscholar   +1 more source