Results 21 to 30 of about 1,775,572 (317)

Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification

open access: yesCancer Biology & Therapy, 2023
The possible anticancer activity of combination (M + E + F) of metformin (M), efavirenz (E), and fluoxetine (F) was investigated in normal HDF cells and HCT116 human colon cancer cells.
Beom-Goo Kang   +13 more
doaj   +1 more source

Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model [PDF]

open access: yes, 2013
Neurogenesis is a life long process, but the rate of cell proliferation and differentiation decreases with age. In Alzheimer's patients, along with age, the presence of Aβ in the brain inhibits this process by reducing stem cell proliferation and cell ...
Vadivel Parthsarathy   +7 more
core   +1 more source

Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies

open access: yesStem Cell Research, 2014
Definitive endoderm (DE) differentiation from mouse embryonic stem cell (mESC) monolayer cultures has been limited by poor cell survival or low efficiency.
Josué Kunjom Mfopou   +6 more
doaj   +1 more source

Modelling cell movement, cell differentiation, cell sorting and proportion regulation in Dictyostelium discoideum aggregations [PDF]

open access: yes, 2015
Understanding the mechanisms that control tissue morphogenesis and homeostasis is a central goal not only in developmental biology but also has great relevance for our understanding of various diseases, including cancer.
Weijer, C. J.; id_orcid   +2 more
core   +1 more source

A novel selection regime for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome [PDF]

open access: yes, 2000
A novel selection scheme has been developed to isolate bloodstream forms of Trypanosoma brucei, which are defective in their ability to differentiate to the procyclic stage.
Wilson, J   +4 more
core   +1 more source

Cell Differentiation and Checkpoint [PDF]

open access: yesInternational Journal of Cancer Research and Molecular Mechanisms ( ISSN 2381-3318 ), 2015
DNA damage is induced in many types of cells by internal and external cell stress. When DNA is damaged, DNA Damage Response (DDR) programs are activated to repair the DNA lesions in order to preserve genomic integrity and suppress subsequent malignant transformation.
Sara Cuesta, Sancho, Toru, Ouchi
openaire   +2 more sources

Putative intermediates in the nerve cell differentiation pathway in hydra have properties of multipotent stem cells [PDF]

open access: yes, 1990
We have investigated the properties of nerve cell precursors in hydra by analyzing the differentiation and proliferation capacity of interstitial cells in the peduncle of Hydra oligactis, which is a region of active nerve cell differentiation.
Charles   +4 more
core   +1 more source

Cell proliferation and differentiation kinetics during spermatogenesis in Hydra carnea [PDF]

open access: yes, 1985
Spermatogenesis inHydra carnea was investigated. The cell proliferation and differentiation kinetics of intermediates in the spermatogenesis pathway were determined, using quantitative determinations of cell abundance, pulse and continuous labelling ...
Munck, Adelheid, David, Charles N.
core   +1 more source

Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment

open access: yesNature Communications, 2022
Limited response to immune checkpoint inhibitors has been reported in patients with castration-resistant prostate cancer. Here the authors show that intermittent, but not continuous, treatment with an anti-PI3Kα/β/δ-inhibitor promotes anti-tumor immunity
Zhi Qi   +8 more
doaj   +1 more source

In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

open access: yesStem Cell Reports, 2017
The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing.
Kohei Yamamizu   +10 more
doaj   +1 more source

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