Results 11 to 20 of about 20,962,508 (350)
Charting cellular identity during human in vitro β-cell differentiation
Nature, 2019 In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this insulin-secreting cell type underlies type 1 diabetes.
Elise N Engquist +2 more
exaly +2 more sources
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
Cell, 2018 Summary In the small intestine, a niche of accessory cell types supports the generation of mature epithelial cell types from intestinal stem cells (ISCs).
Jose Ordovas-Montanes +2 more
exaly +2 more sources
CD8+ T cell differentiation and dysfunction in cancer
Nature reviews. Immunology, 2021 CD8+ T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune checkpoint blockade and adoptive T cell therapy demonstrates the potential of CD8+ T cells to mediate ...
M. Philip, A. Schietinger
semanticscholar +1 more source
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
Cell Metabolism, 2022 Summary Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled by the mitochondrial pyruvate carrier (MPC) impact T cell ...
M. Wenes +18 more
semanticscholar +1 more source
Canadian Respiratory Journal, 2022 Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible, and progressive interstitial lung disease characterized by recurrent alveolar epithelial cell injury, fibroblast hyperproliferation, and cumulative deposition of extracellular matrix leading
Lan Wang +7 more
doaj +1 more source
Overview of CircRNAs Roles and Mechanisms in Liver Fibrosis
Biomolecules, 2023 Liver fibrosis represents the reversible pathological process with the feature of the over-accumulation of extracellular matrix (ECM) proteins within the liver, which results in the deposition of fibrotic tissues and liver dysfunction. Circular noncoding
Gaiping Wang +6 more
doaj +1 more source
Mitochondrial Dysfunction and Chronic Liver Disease
Current Issues in Molecular Biology, 2022 Mitochondria are generally considered the powerhouse of the cell, a small subcellular organelle that produces most of the cellular energy in the form of adenosine triphosphate (ATP). In addition, mitochondria are involved in various biological functions,
Chunyan Zhang +5 more
doaj +1 more source
Criticality in Cell Differentiation [PDF]
Journal of Biosciences, 2016 Abstract Cell differentiation is an important process in living organisms. Differentiation is mostly based on binary decisions with the progenitor cells choosing between two specific lineages. The differentiation dynamics have both deterministic and stochastic components.
Bose, Indrani, Pal, Mainak
openaire +3 more sources
Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model [PDF]
, 2013 Neurogenesis is a life long process, but the rate of cell proliferation and differentiation decreases with age. In Alzheimer's patients, along with age, the presence of Aβ in the brain inhibits this process by reducing stem cell proliferation and cell ...
Vadivel Parthsarathy +7 more
core +3 more sources