Results 21 to 30 of about 687,317 (259)

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

eLife, 2020
Adaptive immunity vitally depends on major histocompatibility complex class I (MHC I) molecules loaded with peptides. Selective loading of peptides onto MHC I, referred to as peptide editing, is catalyzed by tapasin and the tapasin-related TAPBPR.
Lina Sagert, Felix Hennig, Christoph Thomas, Robert Tampé   +3 more
doaj   +1 more source

The Function of Immunoproteasomes—An Immunologists’ Perspective

Cells, 2021
Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in which the constitutive catalytic ...
Bart L. van den Eshof, Lobna Medfai, Emanuele Nolfi, Magdalena Wawrzyniuk, Alice J. A. M. Sijts   +4 more
doaj   +1 more source

Current Concepts of Antigen Cross-Presentation

Frontiers in Immunology, 2018
Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses ...
Maria Embgenbroich, Sven Burgdorf
doaj   +1 more source

Antigen Processing of a Short Viral Antigen by Proteasomes [PDF]

Journal of Biological Chemistry, 2006
Mass spectrometry (MS)-based methods coupled to reverse phase chromatography separation are a useful technology to analyze complex peptide pools that are comprised of different peptides with unrelated sequences. In antigen presentation, proteasomes generate a set of short peptides that are closely related and overlapping and in some instances may even ...
Lopez, Daniel, Calero, Olga, Jimenez, Mercedes, García-Calvo, Margarita, Del Val, Margarita   +4 more
openaire   +3 more sources

The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities

Frontiers in Immunology, 2022
IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban, Adrian Martín-Esteban, Jesus Contreras Rodriguez, David Peske, Jose A. Lopez de Castro, Nilabh Shastri, Scheherazade Sadegh-Nasseri   +6 more
doaj   +1 more source

Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets

Frontiers in Immunology, 2015
Dendritic cells have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8+ T cells. There is strong in vivo evidence that the mouse
Enric eGutiérrez-Martínez, Remi ePlanès, Giorgio eAnselmi, Matthew eReynolds, Shinelle eMenezes, Adiko Assi Aimé Cézaire, Adiko Assi Aimé Cézaire, Loredana eSaveanu, Loredana eSaveanu, Pierre eGuermonprez   +9 more
doaj   +1 more source

Binding of the von Willebrand Factor A Domain of Capillary Morphogenesis Protein 2 to Anthrax Protective Antigen Vaccine Reduces Immunogenicity in Mice

mSphere, 2020
Protective antigen (PA) is a component of anthrax toxin that can elicit toxin-neutralizing antibody responses. PA is also the major antigen in the current vaccine to prevent anthrax, but stability problems with recombinant proteins have complicated the ...
Fabiana Freire Mendes de Oliveira, Sireesha Mamillapalli, Srinivas Gonti, Robert N. Brey, Han Li, Jarad Schiffer, Arturo Casadevall, James G. Bann   +7 more
doaj   +1 more source

Toward a network model of MHC class II-restricted antigen processing

Frontiers in Immunology, 2013
The standard model of Major Histocompatibility Complex class II (MHCII)-restricted antigen processing depicts a straightforward, linear pathway: Internalized antigens are converted into peptides that load in a chaperone dependent manner onto nascent ...
Laurence C Eisenlohr, Michael A Miller, Asha Purnima Veerappan Ganesan   +2 more
doaj   +1 more source

Siglec Receptors Modulate Dendritic Cell Activation and Antigen Presentation to T Cells in Cancer

Frontiers in Cell and Developmental Biology, 2022
Interactions between sialylated glycans and sialic acid-binding immunoglobulin-like lectin (Siglec) receptors have been recently described as potential new immune checkpoint that can be targeted to improve anticancer immunity.
Jinyu Wang, Michela Manni, Anne Bärenwaldt, Ronja Wieboldt, Nicole Kirchhammer, Robert Ivanek, Robert Ivanek, Michal Stanczak, Alfred Zippelius, Alfred Zippelius, David König, David König, Natalia Rodrigues Manutano, Heinz Läubli, Heinz Läubli   +14 more
doaj   +1 more source

Estimation of endoplasmic reticulum aminopeptidase 1 level of expression in lesional and nonlesional skin of psoriatic patients and healthy controls

Journal of the Egyptian Women’s Dermatologic Society, 2021
Background Psoriasis is a chronic inflammatory autoimmune disease of the skin, in which an elevated expression of endoplasmic reticulum aminopeptidase 1 (ERAP1), an enzyme involved in the final processing of major histocompatibility complex-I ligands ...
Dina Metwally, Laila A Rashed, Amul M Badr, Doaa M Elqadi, Rana F Hilal   +4 more
doaj   +1 more source