THE LYMPH SELF ANTIGEN REPERTOIRE
Frontiers in Immunology, 2013 The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature.
Laura eSantambrogio, Cristina eClement
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Neo-Splicetopes in Tumor Therapy: A Lost Case?
Frontiers in Immunology, 2022 Proteasome generates spliced peptides by ligating two distant cleavage products in a reverse proteolysis reaction. The observation that CD8+ T cells recognizing a spliced peptide induced T cell rejection in a melanoma patient following adoptive T cell ...
Peter M. Kloetzel
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Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer: a novel mechanism for enhancing specific antigen presentation [PDF]
, 2007 The B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen specific CD4+ T cells (1).
Ben J. C. Quah +5 more
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Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
Frontiers in Immunology, 2022 Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou +3 more
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Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
, 2010 The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola +3 more
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Information Fusion for Anomaly Detection with the Dendritic Cell Algorithm [PDF]
, 2010 Dendritic cells are antigen presenting cells that provide a vital link between the innate and adaptive immune system, providing the initial detection of pathogenic invaders.
Aickelin, Uwe +2 more
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Proteases: essential actors in processing antigens and intracellular Toll-like receptors
Frontiers in Immunology, 2013 MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4+ T cells.
Bénédicte eManoury
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A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor
eLife, 2020 Adaptive immunity vitally depends on major histocompatibility complex class I (MHC I) molecules loaded with peptides. Selective loading of peptides onto MHC I, referred to as peptide editing, is catalyzed by tapasin and the tapasin-related TAPBPR.
Lina Sagert +3 more
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Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]
, 2003 Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Brömme D. +4 more
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The Function of Immunoproteasomes—An Immunologists’ Perspective
Cells, 2021 Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in which the constitutive catalytic ...
Bart L. van den Eshof +4 more
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