Proteases: essential actors in processing antigens and intracellular Toll-like receptors
Frontiers in Immunology, 2013 MHC class II molecules expressed by professional antigen presenting cells (pAPCs) such as macrophages, B cells and dendritic cells (DCs) play a fundamental role in presenting peptides to CD4+ T cells.
Bénédicte eManoury
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Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
Frontiers in Immunology, 2022 Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou +3 more
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Current Concepts of Antigen Cross-Presentation
Frontiers in Immunology, 2018 Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses ...
Maria Embgenbroich, Sven Burgdorf
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A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor
eLife, 2020 Adaptive immunity vitally depends on major histocompatibility complex class I (MHC I) molecules loaded with peptides. Selective loading of peptides onto MHC I, referred to as peptide editing, is catalyzed by tapasin and the tapasin-related TAPBPR.
Lina Sagert +3 more
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Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1 [PDF]
, 2012 peer-reviewedViruses establishing persistent latent infections have evolved various mechanisms to avoid immune surveillance. The Epstein-Barr virus-encoded nuclear antigen, EBNA1, expressed in all EBV-associated malignancies, modulates its own protein ...
David J Lynn +14 more
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The Function of Immunoproteasomes—An Immunologists’ Perspective
Cells, 2021 Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in which the constitutive catalytic ...
Bart L. van den Eshof +4 more
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Antigen Processing of a Short Viral Antigen by Proteasomes [PDF]
Journal of Biological Chemistry, 2006 Mass spectrometry (MS)-based methods coupled to reverse phase chromatography separation are a useful technology to analyze complex peptide pools that are comprised of different peptides with unrelated sequences. In antigen presentation, proteasomes generate a set of short peptides that are closely related and overlapping and in some instances may even ...
Lopez, Daniel +4 more
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Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment [PDF]
, 1992 Selective expression of murine cytomegalovirus (MCMV) immediate-early (IE) genes leads to the presentation by the major histocompatibility complex (MHC) class I molecule L a of a peptide derived from MCMV IE protein pp89 (Reddehase, M. J., J.
Koszinowski, Ulrich H. +13 more
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The roles of Hsp70 proteins in antigen processing and presentation [PDF]
, 1997 The ability of members of the hsp70 family to bind to peptides in vivo and in vitro suggests that they may be involved in the processing of antigens for binding to Major Histocompatibility (MHC) class I and/or class n molecules.
Winchester, Christopher Charles +2 more
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The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Frontiers in Immunology, 2022 IntroductionCritical steps in Major Histocompatibility Complex Class I (MHC-I) antigen presentation occur in the endoplasmic reticulum (ER). In general, peptides that enter the ER are longer than the optimal length for MHC-I binding.
Adrian Martín-Esteban +6 more
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