Results 1 to 10 of about 841 (65)

Antigen Cross-Presentation by Macrophages

Frontiers in Immunology, 2020
The contribution of dendritic cell (DC) antigen cross-presentation to the activation of CD8+ T lymphocytes for immune defense against tumors, viruses, and intracellular pathogens has been recognized widely.
Elke M. Muntjewerff, Luca D. Meesters, Geert van den Bogaart, Geert van den Bogaart   +3 more
doaj   +3 more sources

Current Concepts of Antigen Cross-Presentation

Frontiers in Immunology, 2018
Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses ...
Maria Embgenbroich, Sven Burgdorf
doaj   +3 more sources

Regulation of Antigen Export to the Cytosol During Cross-Presentation

Frontiers in Immunology, 2019
Cross-priming refers to the induction of primary cytotoxic CD8+ T cell responses to antigens that are not expressed in antigen presenting cells (APCs) responsible for T cell priming.
Marine Gros, Sebastian Amigorena
doaj   +3 more sources

Understanding the biology of antigen cross-presentation for the design of vaccines against cancer

Frontiers in Immunology, 2014
Antigen cross-presentation, the process in which exogenous antigens are presented on MHC class I molecules, is crucial for the generation of effector CD8+ T cell responses.
Cynthia M. Fehres, Wendy W.J. Unger, Juan J. eGarcia-Vallejo, Yvette eVan Kooyk   +3 more
doaj   +3 more sources

Antigen Presentation in the Lung

Frontiers in Immunology, 2022
The lungs are constantly exposed to environmental and infectious agents such as dust, viruses, fungi, and bacteria that invade the lungs upon breathing. The lungs are equipped with an immune defense mechanism that involves a wide variety of immunological
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
doaj   +1 more source

Chemotherapy enhances cross-presentation of nuclear tumor antigens. [PDF]

PLoS ONE, 2014
Cross-presentation of tumor antigen is essential for efficient priming of naïve CD8⁺ T lymphocytes and induction of effective anti-tumor immunity. We hypothesized that the subcellular location of a tumor antigen could affect the efficiency of cross ...
Chidozie C Anyaegbu, Richard A Lake, Kathy Heel, Bruce W Robinson, Scott A Fisher   +4 more
doaj   +1 more source

Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes

eLife, 2023
The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes.
Eli Olson, Theadora Ceccarelli, Malini Raghavan   +2 more
doaj   +1 more source

Direct antigen presentation is the canonical pathway of cytomegalovirus CD8 T-cell priming regulated by balanced immune evasion ensuring a strong antiviral response

Frontiers in Immunology, 2023
CD8 T cells are important antiviral effectors in the adaptive immune response to cytomegaloviruses (CMV). Naïve CD8 T cells can be primed by professional antigen-presenting cells (pAPCs) alternatively by “direct antigen presentation” or “antigen cross ...
Julia K. Büttner, Sara Becker, Annette Fink, Melanie M. Brinkmann, Melanie M. Brinkmann, Rafaela Holtappels, Matthias J. Reddehase, Niels A. Lemmermann, Niels A. Lemmermann   +8 more
doaj   +1 more source

MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy.

PLoS ONE, 2021
Nanoparticles made of the coat protein of papaya mosaic virus (PapMV) and a single-strand RNA were previously shown to be an efficient antigen presentation system for the trigger of cellular immunity.
David Possamaï, Laïla-Aïcha Hanafi, Angélique Bellemare-Pelletier, Katia Hamelin, Paméla Thébault, Marie-Josée Hébert, Étienne Gagnon, Denis Leclerc, Réjean Lapointe   +8 more
doaj   +2 more sources

Antigen processing and remodeling of the endosomal pathway: requirements for antigen cross-presentation.

Frontiers in Immunology, 2012
The cross-presentation of endocytosed antigen as peptide/class I MHC complexes plays a central role in the elicitation of CD8+ T cell clones that mediate anti-viral and anti-tumor immune responses.
Ewoud Bernardus Compeer, Thijs Willem Hendrik Flinsenberg, Susanna Geertje van der Grein, Marianne eBoes   +3 more
doaj   +1 more source