Antigen Cross-Presentation by Macrophages [PDF]
Frontiers in Immunology, 2020 The contribution of dendritic cell (DC) antigen cross-presentation to the activation of CD8+ T lymphocytes for immune defense against tumors, viruses, and intracellular pathogens has been recognized widely.
Elke M. Muntjewerff +3 more
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Current Concepts of Antigen Cross-Presentation [PDF]
Frontiers in Immunology, 2018 Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses ...
Maria Embgenbroich, Sven Burgdorf
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Antigen cross-presentation of immune complexes [PDF]
Frontiers in Immunology, 2014 The ability of dendritic cells (DC) to cross-present tumor antigens has long been a focus of interest of physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A prerequisite for exploiting this pathway
Barbara ePlatzer +2 more
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Regulation of Antigen Export to the Cytosol During Cross-Presentation [PDF]
Frontiers in Immunology, 2019 Cross-priming refers to the induction of primary cytotoxic CD8+ T cell responses to antigens that are not expressed in antigen presenting cells (APCs) responsible for T cell priming.
Marine Gros, Sebastian Amigorena
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The Role of Heat Shock Proteins in Antigen Cross Presentation [PDF]
Frontiers in Immunology, 2012 Heat shock proteins (HSP) are molecular chaperones that can bind tumor antigens (Ag) and mediate their uptake into antigen presenting cells (APC). HSP-antigen complexes are then directed towards the MHC class I pathway through antigen cross presentation ...
Ayesha eMurshid +2 more
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MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy [PDF]
PLoS ONE, 2021 Nanoparticles made of the coat protein of papaya mosaic virus (PapMV) and a single-strand RNA were previously shown to be an efficient antigen presentation system for the trigger of cellular immunity.
David Possamaï +8 more
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Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer [PDF]
Advanced ScienceTumor mutational burden (TMB), usually representing high immunogenicity, cannot always predict treatment response of immune checkpoint blockade (ICB).
Ruxin Wang +10 more
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Dendritic cell-based vaccine prepared with recombinant Lactococcus lactis enhances antigen cross-presentation and antitumor efficacy through ROS production [PDF]
Frontiers in Immunology, 2023 IntroductionLactococcus lactis (L.L) is safe and can be used as vehicle. In this study, the immunoregulatory effect of L.L on dendritic cell (DC) activation and mechanism were investigated. The immune responses and antigen cross-presentation mechanism of
Tingting Zhang +7 more
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ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8+ T cell immunity [PDF]
Nature CommunicationsDendritic cells (DC) dysfunction impedes antitumor immunity, so understanding intrinsic regulators of DC antigen presentation and the resulting activation of antitumor CD8+ T cells could benefit therapy.
Yaxin Liu +12 more
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Cytomegalovirus inhibitors of programmed cell death restrict antigen cross-presentation in the priming of antiviral CD8 T cells. [PDF]
PLoS PathogensCD8 T cells are the predominant effector cells of adaptive immunity in preventing cytomegalovirus (CMV) multiple-organ disease caused by cytopathogenic tissue infection.
Stefan Ebert +7 more
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