Results 21 to 30 of about 6,495,314 (227)
MedCommAntigen uptake, processing, and presentation are crucial for the immune responses of protein‐based vaccines. Herein, we introduced a reversible chemical cross‐linking strategy to engineer protein antigens, which can be tracelessly removed upon antigen ...
Long Chen +13 more
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Molecular and cell-biological mechanisms of antigen cross-presentation [PDF]
Frontiers in Immunology, 2013 Cross-priming serves to activate cytotoxic T lymphocytes for immune defense against viruses and tumors and plays an important role in vaccinations. Only certain dendritic cell (DC) subsets can cross-present. Several cell surface markers have been described that more or less specifically and sensitively characterize these subsets.
Christian eKurts
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Application of Antigen Cross-Presentation Research into Patient Care [PDF]
Frontiers in Immunology, 2014 Dendritic cell (DC)-based cellular immunotherapy is being explored as a treatment modality for several malignancies, for viral diseases and auto-immune disorders. More than four decades of pre-clinical research on DC biology has cemented a strong foundation for clinical application of DC-based clinical trials, which already have been performed since ...
Flinsenberg, Thijs W. H., Boes, ML
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Sec61 in antigen cross-presentation
Oncotarget, 2015 Upon recognition of antigens in the peripheral tissue, dendritic cells (DCs) migrate toward the draining lymph node to present internalized and processed antigens on major histocompatibility complex (MHC) molecules to T cells. In a process termed cross-presentation, antigen-derived peptides are presented on MHC I molecules to cytotoxic T cells.
Matthias, Zehner, Sven, Burgdorf
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Antigen cross-presentation by macrophages
Nauchno-prakticheskii zhurnal «Patogenez», 2021 В обзоре рассматриваются механизмы кросс-презентации антигена и особенности этого процесса в макрофагах. Представлено сравнение особенностей кросс-презентации в дендритных клетках и разных фенотипах макрофагов. Описаны пути кросс-презентации -протеасомный и вакуолярный.
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Studies on the role of cholesterol and coronin 1 in antigen-presenting cells [PDF]
, 2005 Antigen recognition and presentation to subsequently induce an appropriate host response is dependent on the action of antigen-presenting cells such as dendritic cells and macrophages.
Albrecht, Imke
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The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
Frontiers in Immunology, 2012 Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
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If it ain’t broke, break it: facilitating antigen cross-presentation
Trends in Molecular Medicine, 2022 Recently, Bikorimana et al. presented a new vaccine formulation, AccumTM, capable of eliciting efficient T cell-mediated immune responses and controlling tumour growth. AccumTM is designed to facilitate cross-presentation by breaking through endo/lysosomal membranes and enhancing delivery of antigens into the cytosol of dendritic cells (DCs).
Pablo Rodríguez-Silvestre +1 more
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Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes
Frontiers in Immunology, 2017 About a fourth of the human proteome is anchored by transmembrane helices (TMHs) to lipid membranes. TMHs require multiple hydrophobic residues for spanning membranes, and this shows a striking resemblance with the requirements for peptide binding to ...
Frans Bianchi +2 more
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The MARCH family joins the antigen cross‐presentation party [PDF]
Immunology & Cell Biology, 2017 The membrane-associated RING-CH (MARCH) family of E3 ubiquitin ligases is thought to perform predominantly immunoregulatory functions by controlling the localization and abundance of a diverse array of immune receptors. However, the physiological substrates of the MARCHs remain elusive. In this issue of Immunology and Cell Biology, the group of Evelina
Justine D, Mintern, José A, Villadangos
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