Results 21 to 30 of about 176,845 (241)
Application of Antigen Cross-Presentation Research into Patient Care [PDF]
Frontiers in Immunology, 2014 Dendritic cell (DC)-based cellular immunotherapy is being explored as a treatment modality for several malignancies, for viral diseases and auto-immune disorders. More than four decades of pre-clinical research on DC biology has cemented a strong foundation for clinical application of DC-based clinical trials, which already have been performed since ...
Flinsenberg, Thijs W. H., Boes, Marianne
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Sec61 in antigen cross-presentation
Oncotarget, 2015 Upon recognition of antigens in the peripheral tissue, dendritic cells (DCs) migrate toward the draining lymph node to present internalized and processed antigens on major histocompatibility complex (MHC) molecules to T cells. In a process termed cross-presentation, antigen-derived peptides are presented on MHC I molecules to cytotoxic T cells.
Matthias, Zehner, Sven, Burgdorf
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Antigen cross-presentation: proteasome location, location, location. [PDF]
EMBO J, 2019 Our understanding of the mechanisms by which peptides from proteins present in phagosomes and endosomes are processed and presented on MHC class I molecules, in a pathway called cross-presentation, is still incomplete. One of the main questions arising from currently proposed models is how do proteins in the phagosome lumen reach the proteasome in the ...
Desjardins M.
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Antigen cross-presentation by macrophages
Nauchno-prakticheskii zhurnal «Patogenez», 2021 В обзоре рассматриваются механизмы кросс-презентации антигена и особенности этого процесса в макрофагах. Представлено сравнение особенностей кросс-презентации в дендритных клетках и разных фенотипах макрофагов. Описаны пути кросс-презентации -протеасомный и вакуолярный.
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If it ain’t broke, break it: facilitating antigen cross-presentation
Trends in Molecular Medicine, 2022 Recently, Bikorimana et al. presented a new vaccine formulation, AccumTM, capable of eliciting efficient T cell-mediated immune responses and controlling tumour growth. AccumTM is designed to facilitate cross-presentation by breaking through endo/lysosomal membranes and enhancing delivery of antigens into the cytosol of dendritic cells (DCs).
Pablo Rodríguez-Silvestre +1 more
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The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
Frontiers in Immunology, 2012 Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
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Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes
Frontiers in Immunology, 2017 About a fourth of the human proteome is anchored by transmembrane helices (TMHs) to lipid membranes. TMHs require multiple hydrophobic residues for spanning membranes, and this shows a striking resemblance with the requirements for peptide binding to ...
Frans Bianchi +2 more
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The MARCH family joins the antigen cross‐presentation party [PDF]
Immunology & Cell Biology, 2017 The membrane-associated RING-CH (MARCH) family of E3 ubiquitin ligases is thought to perform predominantly immunoregulatory functions by controlling the localization and abundance of a diverse array of immune receptors. However, the physiological substrates of the MARCHs remain elusive. In this issue of Immunology and Cell Biology, the group of Evelina
Justine D, Mintern, José A, Villadangos
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Viral sequestration of antigen subverts cross presentation to CD8(+) T cells. [PDF]
PLoS Pathogens, 2009 Virus-specific CD8(+) T cells (T(CD8+)) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells (pAPC). Peptide-MHC complexes are produced by two spatially distinct pathways during virus infection.
Eric F Tewalt +7 more
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Modes of antigen presentation by lymph node stromal cells and their immunological implications
Frontiers in Immunology, 2015 Antigen presentation is no longer the exclusive domain of cells of hematopoietic origin. Recent works have demonstrated that lymph node stromal cell (LNSC) populations such as fibroblastic reticular cells, lymphatic and blood endothelial cells not only ...
Sachiko eHirosue, Juan eDubrot
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