Results 31 to 40 of about 176,845 (241)

Live Long and Prosper for Antigen Cross-Presentation [PDF]

Immunity, 2015
Even though proteolytic antigen fragments are displayed for cross-presentation, rapid proteolysis of endocytosed antigens inhibits this process. In this issue of Immunity, Alloatti et al. (2015) describe how maturing dendritic cells keep phagosomes and lysosomes apart to ensure extended antigen life that leads to prosperous cross-presentation.
openaire   +4 more sources

Cross-presentation of exogenous antigens on MHC I molecules

Current Opinion in Immunology, 2020
In order to get recognized by CD8 T cells, most cells present peptides from endogenously expressed self or foreign proteins on MHC class I molecules. However, specialized antigen-presenting cells, such as DCs and macrophages, can present exogenous antigen on MHC-I in a process called cross-presentation. This pathway plays key roles in antimicrobial and
Jeff D Colbert, Freidrich M Cruz, Kenneth L Rock   +2 more
openaire   +3 more sources

CaCO3 powder-mediated biomineralization of antigen nanosponges synergize with PD-1 blockade to potentiate anti-tumor immunity

Journal of Nanobiotechnology, 2023
Antigen self-assembly nanovaccines advance the minimalist design of therapeutic cancer vaccines, but the issue of inefficient cross-presentation has not yet been fully addressed.
Runping Su, Jingjing Gu, Juanjuan Sun, Jie Zang, Yuge Zhao, Tingting Zhang, Yingna Chen, Gaowei Chong, Weimin Yin, Xiao Zheng, Bingbing Liu, Li Huang, Shuangrong Ruan, Haiqing Dong, Yan Li, Yongyong Li   +15 more
doaj   +1 more source

Evaluation of Cross-presentation in Bone Marrow-derived Dendritic Cells in vitro and Splenic Dendritic Cells ex vivo Using Antigen-coated Beads

Bio-Protocol, 2016
Antigen presentation by MHC class I molecules, also referred to as cross-presentation, elicits cytotoxic immune responses. In particular, dendritic cells (DC) are the most proficient cross-presenting cells, since they have developed unique means to ...
Andrés Alloatti, Fiorella Kotsias, Eik Hoffmann, Sebastian Amigorena   +3 more
doaj   +1 more source

The neonatal Fc receptor in cancer FcRn in cancer

Cancer Medicine, 2020
Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data
Diana Cadena Castaneda, Guillaume Brachet, Caroline Goupille, Lobna Ouldamer, Valérie Gouilleux‐Gruart   +4 more
doaj   +1 more source

Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens. [PDF]

PLoS ONE, 2012
Antigen cross-presentation involves the uptake and processing of exogenously derived antigens and their assembly with major histocompatibility complex (MHC) class I molecules.
Natasha Del Cid, Lianjun Shen, Janice Belleisle, Malini Raghavan   +3 more
doaj   +1 more source

Activated Brain Endothelial Cells Cross-Present Malaria Antigen. [PDF]

PLoS Pathogens, 2015
In the murine model of cerebral malaria caused by P. berghei ANKA (PbA), parasite-specific CD8+ T cells directly induce pathology and have long been hypothesized to kill brain endothelial cells that have internalized PbA antigen.
Shanshan W Howland, Chek Meng Poh, Laurent Rénia   +2 more
doaj   +1 more source

Endocytic Recycling of MHC Class I Molecules in Non-professional Antigen Presenting and Dendritic Cells

Frontiers in Immunology, 2019
Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells.
Sebastian Montealegre, Sebastian Montealegre, Sebastian Montealegre, Peter M. van Endert, Peter M. van Endert, Peter M. van Endert   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In vitro Ag Cross-presentation and in vivo Ag Cross-presentation by Dendritic Cells in the Mouse

Bio-Protocol, 2012
Antigen cross presentation is important for effective immune responses to tumors and viral infections. Dendritic cells are professional antigen presenting cells and are unique in their ability to cross-present exogenous antigens on MHC class I molecules ...
Mallika Ghosh, Linda H Shapiro
doaj   +1 more source