If it ain’t broke, break it: facilitating antigen cross-presentation
Trends in Molecular Medicine, 2022 Recently, Bikorimana et al. presented a new vaccine formulation, AccumTM, capable of eliciting efficient T cell-mediated immune responses and controlling tumour growth. AccumTM is designed to facilitate cross-presentation by breaking through endo/lysosomal membranes and enhancing delivery of antigens into the cytosol of dendritic cells (DCs).
Pablo Rodríguez-Silvestre +1 more
openaire +2 more sources
Sec61 in antigen cross-presentation
Oncotarget, 2015 Upon recognition of antigens in the peripheral tissue, dendritic cells (DCs) migrate toward the draining lymph node to present internalized and processed antigens on major histocompatibility complex (MHC) molecules to T cells. In a process termed cross-presentation, antigen-derived peptides are presented on MHC I molecules to cytotoxic T cells.
Matthias, Zehner, Sven, Burgdorf
openaire +2 more sources
Antigen cross-presentation by macrophages
Nauchno-prakticheskii zhurnal «Patogenez», 2021 В обзоре рассматриваются механизмы кросс-презентации антигена и особенности этого процесса в макрофагах. Представлено сравнение особенностей кросс-презентации в дендритных клетках и разных фенотипах макрофагов. Описаны пути кросс-презентации -протеасомный и вакуолярный.
openaire +2 more sources
Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1 [PDF]
, 2012 peer-reviewedViruses establishing persistent latent infections have evolved various mechanisms to avoid immune surveillance. The Epstein-Barr virus-encoded nuclear antigen, EBNA1, expressed in all EBV-associated malignancies, modulates its own protein ...
David J Lynn +14 more
core +1 more source
The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
Frontiers in Immunology, 2012 Production of MHC I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding ...
Peter M Van Endert, Loredana eSaveanu
doaj +1 more source
Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes
Frontiers in Immunology, 2017 About a fourth of the human proteome is anchored by transmembrane helices (TMHs) to lipid membranes. TMHs require multiple hydrophobic residues for spanning membranes, and this shows a striking resemblance with the requirements for peptide binding to ...
Frans Bianchi +2 more
doaj +1 more source
Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase [PDF]
, 1989 The regulation of antigen processing and presentation to MHC class I-restricted cytolytic T lymphocytes was studied in cells infected with murine cytomegalovirus. Recognition by cytolytic T lymphocytes of the phosphoprotein pp89, the immunodominant viral
Reddehase, Matthias J. +7 more
core +1 more source
Studies on the role of cholesterol and coronin 1 in antigen-presenting cells [PDF]
, 2005 Antigen recognition and presentation to subsequently induce an appropriate host response is dependent on the action of antigen-presenting cells such as dendritic cells and macrophages.
Albrecht, Imke
core +1 more source
Viral sequestration of antigen subverts cross presentation to CD8(+) T cells. [PDF]
PLoS Pathogens, 2009 Virus-specific CD8(+) T cells (T(CD8+)) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells (pAPC). Peptide-MHC complexes are produced by two spatially distinct pathways during virus infection.
Eric F Tewalt +7 more
doaj +1 more source
Modes of antigen presentation by lymph node stromal cells and their immunological implications
Frontiers in Immunology, 2015 Antigen presentation is no longer the exclusive domain of cells of hematopoietic origin. Recent works have demonstrated that lymph node stromal cell (LNSC) populations such as fibroblastic reticular cells, lymphatic and blood endothelial cells not only ...
Sachiko eHirosue, Juan eDubrot
doaj +1 more source