Results 51 to 60 of about 6,495,314 (227)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Effect of hypochlorous acid on antigen processing and presentation [PDF]

, 2010
Dendritic cells play a key role in both innate and adaptive immunity. Recognition and presentation of antigens on the major histocompatibility complex (MHC) provide an efficient response against infections.
Prokopowicz, Z.M.
core  

Lipid peroxidation causes endosomal antigen release for cross-presentation

, 2016
Dingjan I, Verboogen DRJ, Paardekooper LM, et al. Lipid peroxidation causes endosomal antigen release for cross-presentation. SCIENTIFIC REPORTS. 2016;6(1): 22064.Dendritic cells (DCs) present foreign antigen in major histocompatibility complex (MHC ...
Paardekooper, Laurent M., Figdor, Carl G., Verboogen, Danielle R. J., Revelo, Natalia H., Henriet, Stefanie S. V., Sittig, Simone P., Visser, Linda J., ter Beest, Martin, van den Bogaart, Geert, Dingjan, Ilse, Fischer von Mollard, Gabriele ; https://orcid.org/   +10 more
core   +2 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Autophagy-assisted antigen cross-presentation [PDF]

OncoImmunology, 2012
It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-
Yi, Yongxiang, Zhou, Zhenxian, Shu, Su, Fang, Yuan, Twitty, Chris, Hilton, Traci L., Aung, Sandra, Urba, Walter J., Fox, Bernard A., Hu, Hong-Ming, Li, Yuhuan   +10 more
openaire   +2 more sources

Enzyme-triggered antigen release enhances cross presentation by dendritic cells

, 2022
Nanoparticles hold great potential as vaccine carriers due to their highly versatile structure and the possibility to influence intracellular trafficking and antigen presentation by their design.
Bülow, Sigrid, Holzinger, Jonas M., Stahl, Monika, Goepferich, Achim, Sigrid Bülow, Monika Stahl, Achim M. Goepferich, Jonas Holzinger   +7 more
core   +1 more source

Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.

PLoS Pathogens, 2015
Naïve anti-viral CD8+ T cells (TCD8+) are activated by the presence of peptide-MHC Class I complexes (pMHC-I) on the surface of professional antigen presenting cells (pAPC).
Janet J Sei, Scott Haskett, Lauren W Kaminsky, Eugene Lin, Mary E Truckenmiller, Clifford J Bellone, R Mark Buller, Christopher C Norbury   +7 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Ly6C+ monocyte efferocytosis and cross-presentation of cell-associated antigens [PDF]

Cell Death & Differentiation, 2016
Recently it was shown that circulating Ly6C(+) monocytes traffic from tissue to the draining lymph nodes (LNs) with minimal alteration in their overall phenotype. Furthermore, in the steady state, Ly6C(+) monocytes are as abundant as classical dendritic cells (DCs) within the draining LNs, and even more abundant during inflammation.
Larson, S R, Atif, S M, Gibbings, S L, Thomas, S M, Prabagar, M G, Danhorn, T, Leach, S M, Henson, P M, Jakubzick, C V   +8 more
openaire   +2 more sources

Efficient antigen cross-presentation through coating conventional aluminum adjuvant particles with PEI.

, 2021
Classical aluminum adjuvant is a deficient antigen carrier for cross-presentation and cross-priming of CD8+ cytotoxic T cells. Our previous research has demonstrated that cross-presentation efficiency significantly increased when antigens are conjugated ...
Wang, Lixin, Hu, Hongming, Lin, Lin, Ren, Hongyan, Mou, Yongbin   +4 more
core   +1 more source