Results 61 to 70 of about 6,214,641 (266)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effect of hypochlorous acid on antigen processing and presentation [PDF]

, 2010
Dendritic cells play a key role in both innate and adaptive immunity. Recognition and presentation of antigens on the major histocompatibility complex (MHC) provide an efficient response against infections.
Prokopowicz, Z.M.
core  

In vitro Ag Cross-presentation and in vivo Ag Cross-presentation by Dendritic Cells in the Mouse

Bio-Protocol, 2012
Antigen cross presentation is important for effective immune responses to tumors and viral infections. Dendritic cells are professional antigen presenting cells and are unique in their ability to cross-present exogenous antigens on MHC class I molecules ...
Mallika Ghosh, Linda H Shapiro
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation. [PDF]

, 2005
International audienceAntigen derived from engulfed apoptotic cells can be cross-presented by dendritic cells (DCs) for the generation of major histocompatibility class I/peptide complexes. While the early events of recognition and internalization of the
Nathalie E Blachère, Robert B Darnell, Albert Matthew L, Albert, Matthew, L., Robert B Darnell (58246), Matthew L Albert (31925), Nathalie E Blachère (58245), Darnell Robert B, Matthew L Albert, Blachère Nathalie E, Blachère, Nathalie, E., Darnell, Robert, B.   +11 more
core   +1 more source

Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.

PLoS Pathogens, 2015
Naïve anti-viral CD8+ T cells (TCD8+) are activated by the presence of peptide-MHC Class I complexes (pMHC-I) on the surface of professional antigen presenting cells (pAPC).
Janet J Sei, Scott Haskett, Lauren W Kaminsky, Eugene Lin, Mary E Truckenmiller, Clifford J Bellone, R Mark Buller, Christopher C Norbury   +7 more
doaj   +1 more source

Cross-presentation of antigens by dendritic cells: role of autophagy

Oncotarget, 2015
Dendritic cells (DCs) are a heterogeneous population of antigen presenting cells(APCs) that initiate and orient immune responses. They sense the pathogens and pathogen-derived antigenic molecules via pattern recognition receptors(PRRs). They process and present extracellular antigens in the context of major histocompatibility complex (MHC) class II ...
Das, Mrinmoy, Kaveri, Srini, Ayry, Jagadeesh   +2 more
openaire   +3 more sources

Autophagy-assisted antigen cross-presentation [PDF]

OncoImmunology, 2012
It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-
Yi, Yongxiang, Zhou, Zhenxian, Shu, Su, Fang, Yuan, Twitty, Chris, Hilton, Traci L., Aung, Sandra, Urba, Walter J., Fox, Bernard A., Hu, Hong-Ming, Li, Yuhuan   +10 more
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ly6C+ monocyte efferocytosis and cross-presentation of cell-associated antigens [PDF]

Cell Death & Differentiation, 2016
Recently it was shown that circulating Ly6C(+) monocytes traffic from tissue to the draining lymph nodes (LNs) with minimal alteration in their overall phenotype. Furthermore, in the steady state, Ly6C(+) monocytes are as abundant as classical dendritic cells (DCs) within the draining LNs, and even more abundant during inflammation.
Larson, S R, Atif, S M, Gibbings, S L, Thomas, S M, Prabagar, M G, Danhorn, T, Leach, S M, Henson, P M, Jakubzick, C V   +8 more
openaire   +2 more sources