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The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation [PDF]

Frontiers in Immunology
IntroductionModified Vaccinia Virus Ankara (MVA) is a safe vaccine vector inducing long- lasting and potent immune responses. MVA-mediated CD8+T cell responses are optimally induced, if both, direct- and cross-presentation of viral or recombinant ...
Ylenia Longo, Sara Moreno Mascaraque, Giuseppe Andreacchio, Julia Werner, Ichiro Katahira, Elena De Marchi, Anna Pegoraro, Robert Jan Lebbink, Karl Köhrer, Patrick Petzsch, Ronny Tao, Francesco Di Virgilio, Elena Adinolfi, Ingo Drexler   +13 more
doaj   +2 more sources

Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets

Frontiers in Immunology, 2015
Dendritic cells have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8+ T cells. There is strong in vivo evidence that the mouse
Enric eGutiérrez-Martínez, Remi ePlanès, Giorgio eAnselmi, Matthew eReynolds, Shinelle eMenezes, Adiko Assi Aimé Cézaire, Adiko Assi Aimé Cézaire, Loredana eSaveanu, Loredana eSaveanu, Pierre eGuermonprez   +9 more
doaj   +3 more sources

STxB as an Antigen Delivery Tool for Mucosal Vaccination

Toxins, 2022
Immunotherapy against cancer and infectious disease holds the promise of high efficacy with minor side effects. Mucosal vaccines to protect against tumors or infections disease agents that affect the upper airways or the lung are still lacking, however ...
Eric Tartour, Ludger Johannes
doaj   +1 more source

Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes

eLife, 2023
The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes.
Eli Olson, Theadora Ceccarelli, Malini Raghavan   +2 more
doaj   +1 more source

Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Frontiers in Cell and Developmental Biology, 2023
Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells.
Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S. Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida   +5 more
doaj   +1 more source

Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines

Frontiers in Immunology, 2021
Peptide-based cancer vaccines rely upon the strong activation of the adaptive immune response to elicit its effector function. They have shown to be highly specific and safe, but have yet to prove themselves as an efficacious treatment for cancer in the ...
Alexander J. Stephens, Alexander J. Stephens, Nicola A. Burgess-Brown, Shisong Jiang   +3 more
doaj   +1 more source

Reinforcement of cell-mediated immunity driven by tumor-associated Epstein-Barr virus (EBV)-specific T cells during targeted B-cell therapy with rituximab

Frontiers in Immunology, 2023
IntroductionIn immunocompromised patients, Epstein-Barr virus (EBV) infection or reactivation is associated with increased morbidity and mortality, including the development of B-cell lymphomas.
Sabine Tischer-Zimmermann, Agnes Bonifacius, Maria Michela Santamorena, Philip Mausberg, Sven Stoll, Marius Döring, Ulrich Kalinke, Rainer Blasczyk, Britta Maecker-Kolhoff, Britta Maecker-Kolhoff, Britta Eiz-Vesper, Britta Eiz-Vesper   +11 more
doaj   +1 more source

Recent Advances in Nanotechnology for Dendritic Cell-Based Immunotherapy

Frontiers in Pharmacology, 2020
Dendritic cells (DCs) are the most important antigen-presenting cells that determine cancer immune responses by regulating immune activation and tolerance, especially in the initiation stage of specific responses.
Chen Qian, Li-Jun Yang, Hong Cui
doaj   +1 more source

Chlamydia trachomatis Infection Impairs MHC-I Intracellular Trafficking and Antigen Cross-Presentation by Dendritic Cells

Frontiers in Immunology, 2021
During cross-presentation, exogenous antigens (i.e. intracellular pathogens or tumor cells) are internalized and processed within the endocytic system and also by the proteasome in the cytosol.
Diego Del Balzo, Anahí Capmany, Ignacio Cebrian, María Teresa Damiani   +3 more
doaj   +1 more source

Photochemically-Mediated Inflammation and Cross-Presentation of Mycobacterium bovis BCG Proteins Stimulates Strong CD4 and CD8 T-Cell Responses in Mice

Frontiers in Immunology, 2022
Conventional vaccines are very efficient in the prevention of bacterial infections caused by extracellular pathogens due to effective stimulation of pathogen-specific antibodies.
Ying Waeckerle-Men, Zuzanna K. Kotkowska, Géraldine Bono, Agathe Duda, Isabel Kolm, Eleni M. Varypataki, Beat Amstutz, Michael Meuli, Anders Høgset, Thomas M. Kündig, Cornelia Halin, Peter Sander, Peter Sander, Pål Johansen   +13 more
doaj   +1 more source