A generic polymer-protein ligation strategy for vaccine delivery [PDF]
, 2016 Although the field of cancer immunotherapy is intensively investigated, there is still a need for generic strategies that allow easy, mild and efficient formulation of vaccine antigens.
De Geest, Bruno +6 more
core +1 more source
Sec61 in antigen cross-presentation
Oncotarget, 2015 Upon recognition of antigens in the peripheral tissue, dendritic cells (DCs) migrate toward the draining lymph node to present internalized and processed antigens on major histocompatibility complex (MHC) molecules to T cells. In a process termed cross-presentation, antigen-derived peptides are presented on MHC I molecules to cytotoxic T cells.
Matthias, Zehner, Sven, Burgdorf
openaire +2 more sources
Role of Immunoproteasomes in Cross-Presentation [PDF]
The Journal of Immunology, 2006 Abstract The evidence that proteasomes are involved in the processing of cross-presented proteins is indirect and based on the in vitro use of proteasome inhibitors. It remains, therefore, unclear whether cross-presentation of MHC class I peptide epitopes can occur entirely within phagolysosomes or whether it requires proteasome ...
Palmowski, M +10 more
openaire +3 more sources
Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides
Frontiers in Immunology, 2019 Human leukocyte antigen (HLA) alleles have a high degree of polymorphism, which determines their peptide-binding motifs and subsequent T-cell receptor recognition.
Shiyan Zhu +21 more
doaj +1 more source
Clinical implications of antigen transfer mechanisms from malignant to dendritic cells: Exploiting cross-priming [PDF]
, 2002 Expansion and activation of cytolytic T lymphocytes bearing high-affinity T-cell receptors specific for tumor antigens is a major goal of active cancer immunotherapy.
Alfaro, C. (Carlos) +9 more
core +1 more source
3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells [PDF]
, 2017 Immunotherapy efficacy relies on the crosstalk within the tumor microenvironment between cancer and dendritic cells (DCs) resulting in the induction of a potent and effective antitumor response.
Bentivegna, Enrico +19 more
core +1 more source
Beta2-Adrenoreceptor agonist inhibits antigen cross-presentation by dendritic cells [PDF]
, 2013 Despite widespread usage of β-adrenergic receptor (AR) agonists and antagonists in current clinical practice, our understanding of their interactions with the immune system is surprisingly sparse. Among the AR expressed by dendritic cells (DC), β2-AR can
Anegon, Ignacio +9 more
core +4 more sources
Shaping of T Cell Functions by Trogocytosis
Cells, 2021 Trogocytosis is an active process whereby plasma membrane proteins are transferred from one cell to the other cell in a cell-cell contact-dependent manner.
Masafumi Nakayama +3 more
doaj +1 more source
Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies [PDF]
, 2011 Background Heat shock protein 70 (HSP70) has gained major attention as an adjuvant capable of inducing antigen-specific CD8+ and CD4+ T-cell responses.
Sabine Tischer +6 more
core +1 more source
Into the Intracellular Logistics of Cross-Presentation [PDF]
Frontiers in Immunology, 2012 The induction of cytotoxic CD8(+) T cell responses requires the presentation of antigenic peptides by MHC class I molecules (MHC I). MHC I usually present peptides derived from endogenous proteins. However, some subtypes of dendritic cells have developed the ability to efficiently present peptides derived from exogenous antigens on MHC I via a process ...
Neefjes, Jacques, Sadaka, Charlotte
openaire +3 more sources