Results 31 to 40 of about 6,688,450 (306)

Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations

Frontiers in Immunology, 2012
Cross-presentation of cell-associated antigens (Ag) plays an important role in the induction of anti-tumor responses, autoimmune diseases, and transplant rejection.
Edith M Janssen, Robert I Thacker
doaj   +1 more source

Vaccine-Induced CD8+ T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation

Frontiers in Immunology, 2020
Infections are most common and most severe at the extremes of age, the young and the elderly. Vaccination can be a key approach to enhance immunogenicity and protection against pathogens in these vulnerable populations, who have a functionally distinct ...
Elisabeth M. S. Beijnen, Elisabeth M. S. Beijnen, Elisabeth M. S. Beijnen, Simon D. van Haren, Simon D. van Haren   +4 more
doaj   +1 more source

Intracellular events regulating cross-presentation [PDF]

Frontiers in Immunology, 2012
Cross-presentation plays a fundamental role in the induction of CD8-T cell immunity. However, although more than three decades have passed since its discovery, surprisingly little is known about the exact mechanisms involved. Here we give an overview of the components involved at different stages of this process.
Wagner, Claudia S., Grotzke, Jeffrey E., Cresswell, Peter   +2 more
openaire   +3 more sources

Endocytic Recycling of MHC Class I Molecules in Non-professional Antigen Presenting and Dendritic Cells

Frontiers in Immunology, 2019
Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells.
Sebastian Montealegre, Sebastian Montealegre, Sebastian Montealegre, Peter M. van Endert, Peter M. van Endert, Peter M. van Endert   +5 more
doaj   +1 more source

Chemokines: a new dendritic cell signal for T cell activation

Frontiers in Immunology, 2011
Dendritic cells (DCs) are the main inducers and regulators of cytotoxic T lymphocyte (CTL) responses against viruses and tumors. One checkpoint to avoid misguided CTL activation, which might damage healthy cells of the body, is the necessity for multiple
Christoph A Thaiss, Verena eSemmling, Lars eFranken, Hermann eWagner, Christian eKurts   +4 more
doaj   +1 more source

An updated view of the intracellular mechanisms regulating cross-presentation

Frontiers in Immunology, 2013
Cross-presentation involves the presentation of peptides derived from internalized cargo on major histocompatibility complex class I molecules by dendritic cells, a process critical for tolerance and immunity.
Julie Magarian eBlander, Priyanka eNair-Gupta   +1 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Toll-Like Receptor 4 Triggering Promotes Cytosolic Routing of DC-SIGN-Targeted Antigens for Presentation on MHC Class I

Frontiers in Immunology, 2018
DC-SIGN is an antigen uptake receptor expressed on dendritic cells (DCs) with specificity for glycans present on a broad variety of pathogens and is capable of directing its cargo to MHC-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell ...
Sophie K. Horrevorts, Sanne Duinkerken, Karien Bloem, Karien Bloem, Pablo Secades, Hakan Kalay, René J. Musters, Sandra J. van Vliet, Juan J. García-Vallejo, Yvette van Kooyk   +9 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Cross family christmas card, 1957 [picture] : "greetings at christmas 1957 From stan and jess cross and stephen" /

, 1957
Part of the Stan Cross Archive of cartoons and drawings, 1912-1974.; Copy of original drawing. "Greetings at Christmas 1957 From Stan and Jess Cross and Stephen"; Also available in an electronic version via the internet at: http://nla.gov.au/nla.pic ...
Cross, Stan, 1888-1977.
core   +2 more sources