Results 31 to 40 of about 526,765 (304)

Increases in Cellular Immune Responses Due to Positive Effect of CVC1302-Induced Lysosomal Escape in Mice

Vaccines, 2023
This study found a higher percentage of CD8+ T cells in piglets immunized with a CVC1302-adjuvanted inactivated foot-and-mouth disease virus (FMDV) vaccine. We wondered whether the CVC1302-adjuvanted inactivated FMDV vaccine promoted cellular immunity by
Xiaoming Yu, Yuanyuan Zhang, Liting Hou, Xuwen Qiao, Yuanpeng Zhang, Haiwei Cheng, Haiyan Lu, Jin Chen, Luping Du, Qisheng Zheng, Jibo Hou, Guangzhi Tong   +11 more
doaj   +1 more source

Oncolytic Immunotherapy: Dying the Right Way is a Key to Eliciting Potent Antitumor Immunity

Frontiers in Oncology, 2014
Oncolytic viruses (OVs) are novel immunotherapeutic agents whose anticancer effects come from both oncolysis and elicited antitumor immunity. OVs induce mostly immunogenic cancer cell death (ICD), including immunogenic apoptosis, necrosis/necroptosis ...
Zong Sheng eGuo, Zuqiang eLiu, David L Bartlett   +2 more
doaj   +1 more source

Tumor-Derived Autophagosomes (DRibbles) Activate Human B Cells to Induce Efficient Antigen-Specific Human Memory T-Cell Responses

Frontiers in Immunology, 2021
We have reported that tumor-derived autophagosomes (DRibbles) were efficient carriers of tumor antigens and DRibbles antigens could be present by DRibbles-activated B cells to stimulate effect and naïve T cells in mice. However, the effect of DRibbles on
Hongyan Ren, Tianyu Zhang, Yongren Wang, Qi Yao, Ziyu Wang, Luyao Zhang, Lixin Wang   +6 more
doaj   +1 more source

Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii [PDF]

, 2016
We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) for their ability to protect against Toxoplasma gondii in HLA transgenic mice.
Alexander, Jeff, Bi, Stephanie, Broderick, Kate E., Cardona, Nestor, Chentoufi, Aziz A., Dubey, Jitenter P., El Bissati, Kamal, Fox, Chris, Frazeck, Laura, Guderian, Jeffrey A., Krishack, Paulette A., Lykins, Joseph, McLeod, Rima, Mui, Ernest, Reardon, Catherine A., Reed, Steven, Roberts, Craig W., Sa, Qila, Sette, Alessandro, Sidney, John, Suzuki, Yasuhiro, Vang, Lo, Vedvick, Tom, Verma, Shiv K., Woods, Stuart, Zhou, Ying   +25 more
core   +1 more source

The Role of Nanovaccine in Cross-Presentation of Antigen-Presenting Cells for the Activation of CD8⁺ T Cell Responses

Pharmaceutics, 2019
Explosive growth in nanotechnology has merged with vaccine development in the battle against diseases caused by bacterial or viral infections and malignant tumors.
Cheol Gyun Kim, Yoon-Chul Kye, Cheol-Heui Yun   +2 more
doaj   +1 more source

Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria [PDF]

, 2015
BACKGROUND Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria.
Bijker, Else M, Cockburn, Ian, Nganou-Makamdop, Krystelle, Sauerwein, Robert W, van Gemert, Geert-Jan, Zavala, Fidel   +5 more
core   +2 more sources

Identification of a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells in Teleost Respiratory Surfaces

Frontiers in Immunology, 2018
Dendritic cells (DCs) are highly specialized antigen-presenting cells that bridge innate and adaptive immune responses in vertebrates, being key modulators in the initiation of specific responses.
Irene Soleto, Uwe Fischer, Carolina Tafalla, Aitor G. Granja   +3 more
doaj   +1 more source

Antigen presenting capacity of murine splenic myeloid cells [PDF]

, 2017
BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying, O'Neill, Helen C, Quah, Benjamin   +2 more
core   +2 more sources

Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation [PDF]

, 2016
Saponin-based adjuvants (SBAs) are being used in animal and human (cancer) vaccines, as they induce protective cellular immunity. Their adjuvant potency is a factor of inflammasome activation and enhanced antigen cross-presentation by dendritic cells ...
Adema, Gosse J., Amigorena, Sebastian, Bull, Christian, de Graaf, Annemarie M., den Brok, Martijn H., Minderman, Marthe, Rijke, Eric O., Schrier, Carla C., Thakur, Mayank, Wagenaars, Jori A., Wassink, Melissa   +10 more
core   +5 more sources

Efficient Uptake of Recombinant Lipidated Survivin by Antigen-Presenting Cells Initiates Antigen Cross-Presentation and Antitumor Immunity

Frontiers in Immunology, 2018
Survivin is overexpressed in various types of human cancer, but rarely expressed in terminally differentiated adult tissues. Thus, survivin is a potential target antigen for a cancer vaccine.
Chen-Yi Chiang, Yi-Jyun Chen, Chiao-Chieh Wu, Shih-Jen Liu, Shih-Jen Liu, Chih-Hsiang Leng, Chih-Hsiang Leng, Hsin-Wei Chen, Hsin-Wei Chen   +8 more
doaj   +1 more source