Results 31 to 40 of about 530,471 (260)

Cross-presentation: how to get there – or how to get the ER

Frontiers in Immunology, 2012
Antigen cross-presentation enables dendritic cells to present extracellular antigens on MHC I molecules, a process that plays an important role in the induction of immune responses against viruses and tumors and in the induction of peripheral tolerance ...
Christoph eKreer, Judith eRauen, Matthias eZehner, Sven eBurgdorf   +3 more
doaj   +1 more source

Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations

Frontiers in Immunology, 2012
Cross-presentation of cell-associated antigens (Ag) plays an important role in the induction of anti-tumor responses, autoimmune diseases, and transplant rejection.
Edith M Janssen, Robert I Thacker
doaj   +1 more source

Vaccine-Induced CD8+ T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation

Frontiers in Immunology, 2020
Infections are most common and most severe at the extremes of age, the young and the elderly. Vaccination can be a key approach to enhance immunogenicity and protection against pathogens in these vulnerable populations, who have a functionally distinct ...
Elisabeth M. S. Beijnen, Elisabeth M. S. Beijnen, Elisabeth M. S. Beijnen, Simon D. van Haren, Simon D. van Haren   +4 more
doaj   +1 more source

Intracellular events regulating cross-presentation [PDF]

Frontiers in Immunology, 2012
Cross-presentation plays a fundamental role in the induction of CD8-T cell immunity. However, although more than three decades have passed since its discovery, surprisingly little is known about the exact mechanisms involved. Here we give an overview of the components involved at different stages of this process.
Wagner, Claudia S., Grotzke, Jeffrey E., Cresswell, Peter   +2 more
openaire   +3 more sources

Endocytic Recycling of MHC Class I Molecules in Non-professional Antigen Presenting and Dendritic Cells

Frontiers in Immunology, 2019
Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells.
Sebastian Montealegre, Sebastian Montealegre, Sebastian Montealegre, Peter M. van Endert, Peter M. van Endert, Peter M. van Endert   +5 more
doaj   +1 more source

Chemokines: a new dendritic cell signal for T cell activation

Frontiers in Immunology, 2011
Dendritic cells (DCs) are the main inducers and regulators of cytotoxic T lymphocyte (CTL) responses against viruses and tumors. One checkpoint to avoid misguided CTL activation, which might damage healthy cells of the body, is the necessity for multiple
Christoph A Thaiss, Verena eSemmling, Lars eFranken, Hermann eWagner, Christian eKurts   +4 more
doaj   +1 more source

An updated view of the intracellular mechanisms regulating cross-presentation

Frontiers in Immunology, 2013
Cross-presentation involves the presentation of peptides derived from internalized cargo on major histocompatibility complex class I molecules by dendritic cells, a process critical for tolerance and immunity.
Julie Magarian eBlander, Priyanka eNair-Gupta   +1 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Toll-Like Receptor 4 Triggering Promotes Cytosolic Routing of DC-SIGN-Targeted Antigens for Presentation on MHC Class I

Frontiers in Immunology, 2018
DC-SIGN is an antigen uptake receptor expressed on dendritic cells (DCs) with specificity for glycans present on a broad variety of pathogens and is capable of directing its cargo to MHC-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell ...
Sophie K. Horrevorts, Sanne Duinkerken, Karien Bloem, Karien Bloem, Pablo Secades, Hakan Kalay, René J. Musters, Sandra J. van Vliet, Juan J. García-Vallejo, Yvette van Kooyk   +9 more
doaj   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source