Results 31 to 40 of about 6,252,002 (304)

Efficient Uptake of Recombinant Lipidated Survivin by Antigen-Presenting Cells Initiates Antigen Cross-Presentation and Antitumor Immunity

Frontiers in Immunology, 2018
Survivin is overexpressed in various types of human cancer, but rarely expressed in terminally differentiated adult tissues. Thus, survivin is a potential target antigen for a cancer vaccine.
Chen-Yi Chiang, Yi-Jyun Chen, Chiao-Chieh Wu, Shih-Jen Liu, Shih-Jen Liu, Chih-Hsiang Leng, Chih-Hsiang Leng, Hsin-Wei Chen, Hsin-Wei Chen   +8 more
doaj   +1 more source

Cross-presentation: how to get there – or how to get the ER

Frontiers in Immunology, 2012
Antigen cross-presentation enables dendritic cells to present extracellular antigens on MHC I molecules, a process that plays an important role in the induction of immune responses against viruses and tumors and in the induction of peripheral tolerance ...
Christoph eKreer, Judith eRauen, Matthias eZehner, Sven eBurgdorf   +3 more
doaj   +1 more source

Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations

Frontiers in Immunology, 2012
Cross-presentation of cell-associated antigens (Ag) plays an important role in the induction of anti-tumor responses, autoimmune diseases, and transplant rejection.
Edith M Janssen, Robert I Thacker
doaj   +1 more source

Vaccine-Induced CD8+ T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation

Frontiers in Immunology, 2020
Infections are most common and most severe at the extremes of age, the young and the elderly. Vaccination can be a key approach to enhance immunogenicity and protection against pathogens in these vulnerable populations, who have a functionally distinct ...
Elisabeth M. S. Beijnen, Elisabeth M. S. Beijnen, Elisabeth M. S. Beijnen, Simon D. van Haren, Simon D. van Haren   +4 more
doaj   +1 more source

Endocytic Recycling of MHC Class I Molecules in Non-professional Antigen Presenting and Dendritic Cells

Frontiers in Immunology, 2019
Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells.
Sebastian Montealegre, Sebastian Montealegre, Sebastian Montealegre, Peter M. van Endert, Peter M. van Endert, Peter M. van Endert   +5 more
doaj   +1 more source

Chemokines: a new dendritic cell signal for T cell activation

Frontiers in Immunology, 2011
Dendritic cells (DCs) are the main inducers and regulators of cytotoxic T lymphocyte (CTL) responses against viruses and tumors. One checkpoint to avoid misguided CTL activation, which might damage healthy cells of the body, is the necessity for multiple
Christoph A Thaiss, Verena eSemmling, Lars eFranken, Hermann eWagner, Christian eKurts   +4 more
doaj   +1 more source

An updated view of the intracellular mechanisms regulating cross-presentation

Frontiers in Immunology, 2013
Cross-presentation involves the presentation of peptides derived from internalized cargo on major histocompatibility complex class I molecules by dendritic cells, a process critical for tolerance and immunity.
Julie Magarian eBlander, Priyanka eNair-Gupta   +1 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Toll-Like Receptor 4 Triggering Promotes Cytosolic Routing of DC-SIGN-Targeted Antigens for Presentation on MHC Class I

Frontiers in Immunology, 2018
DC-SIGN is an antigen uptake receptor expressed on dendritic cells (DCs) with specificity for glycans present on a broad variety of pathogens and is capable of directing its cargo to MHC-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell ...
Sophie K. Horrevorts, Sanne Duinkerken, Karien Bloem, Karien Bloem, Pablo Secades, Hakan Kalay, René J. Musters, Sandra J. van Vliet, Juan J. García-Vallejo, Yvette van Kooyk   +9 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source