Results 11 to 20 of about 526,765 (304)
Antigen Cross-Presentation of Immune Complexes [PDF]
Frontiers in Immunology, 2014 The ability of dendritic cells (DCs) to cross-present tumor antigens has long been a focus of interest to physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy.
Fiebiger, Edda +2 more
core +7 more sources
The evolving biology of cross-presentation. [PDF]
Semin Immunol, 2023 Cross-priming was first recognized in the context of in vivo cytotoxic T lymphocyte (CTL) responses generated against minor histocompatibility antigens induced by immunization with lymphoid cells. Even though the basis for T cell antigen recognition was still largely unclear at that time, these early studies recognized the implication that such minor ...
Ohara RA, Murphy KM.
europepmc +3 more sources
Intracellular events regulating cross-presentation [PDF]
Frontiers in Immunology, 2012 Cross-presentation plays a fundamental role in the induction of CD8-T cell immunity. However, although more than three decades have passed since its discovery, surprisingly little is known about the exact mechanisms involved. Here we give an overview of the components involved at different stages of this process.
Wagner, Claudia S. +2 more
openaire +3 more sources
Heat Shock Protein Magic in Antigen Trafficking within Dendritic Cells:Implications in Antigen Cross-presentation in Immunity [PDF]
, 2012 Dendritic cells (DCs) take up soluble- or cell-associated antigens and digest them, delivering fragments to the MHC class I pathway to display antigenic peptides to CD8＋ T cells, a process known as cross-presentation.
Udono, Heiichiro
core +1 more source
Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]
, 2018 Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D +13 more
core +1 more source
The many roads to cross-presentation [PDF]
The Journal of Experimental Medicine, 2005 Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system ...
Groothuis, Tom A.M., Neefjes, Jacques
openaire +2 more sources
Frontiers in Immunology, 2021 During cross-presentation, exogenous antigens (i.e. intracellular pathogens or tumor cells) are internalized and processed within the endocytic system and also by the proteasome in the cytosol.
Diego Del Balzo +3 more
doaj +1 more source
Frontiers in Immunology, 2022 Conventional vaccines are very efficient in the prevention of bacterial infections caused by extracellular pathogens due to effective stimulation of pathogen-specific antibodies.
Ying Waeckerle-Men +13 more
doaj +1 more source
Intracellular transport routes for MHC class I and their relevance for antigen cross-presentation
Frontiers in Immunology, 2015 Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and in the maintenance of immune tolerance.
Cézaire Aimé Adiko +4 more
doaj +1 more source
The Macroautophagy Machinery in MHC Restricted Antigen Presentation
Frontiers in Immunology, 2021 Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated phagocytosis (LAP) and LC3-dependent extracellular vesicle loading and secretion (LDELS).
Christian Münz
doaj +1 more source