Results 11 to 20 of about 530,471 (260)
The evolving biology of cross-presentation. [PDF]
Semin Immunol, 2023 Cross-priming was first recognized in the context of in vivo cytotoxic T lymphocyte (CTL) responses generated against minor histocompatibility antigens induced by immunization with lymphoid cells. Even though the basis for T cell antigen recognition was still largely unclear at that time, these early studies recognized the implication that such minor ...
Ohara RA, Murphy KM.
europepmc +3 more sources
Into the Intracellular Logistics of Cross-Presentation [PDF]
Frontiers in Immunology, 2012 The induction of cytotoxic CD8(+) T cell responses requires the presentation of antigenic peptides by MHC class I molecules (MHC I). MHC I usually present peptides derived from endogenous proteins. However, some subtypes of dendritic cells have developed the ability to efficiently present peptides derived from exogenous antigens on MHC I via a process ...
Neefjes, Jacques, Sadaka, Charlotte
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The many roads to cross-presentation [PDF]
The Journal of Experimental Medicine, 2005 Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system ...
Groothuis, Tom A.M., Neefjes, Jacques
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Role of Immunoproteasomes in Cross-Presentation [PDF]
The Journal of Immunology, 2006 Abstract The evidence that proteasomes are involved in the processing of cross-presented proteins is indirect and based on the in vitro use of proteasome inhibitors. It remains, therefore, unclear whether cross-presentation of MHC class I peptide epitopes can occur entirely within phagolysosomes or whether it requires proteasome ...
Palmowski, M +10 more
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Vaccine adjuvants to engage the cross-presentation pathway. [PDF]
Front Immunol, 2022 Adjuvants are indispensable components of vaccines for stimulating optimal immune responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral and T cell-mediated immunity is paramount to defend against diseases caused by complex intracellular pathogens, such as tuberculosis, malaria, and AIDS.
Lee W, Suresh M.
europepmc +4 more sources
Mining the Resource of Cross-Presentation [PDF]
Frontiers in Immunology, 2014 NA
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Antigen Cross-Presentation of Immune Complexes [PDF]
Frontiers in Immunology, 2014 The ability of dendritic cells (DCs) to cross-present tumor antigens has long been a focus of interest to physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A prerequisite for exploiting this pathway for therapeutic purposes is a better understanding of the mechanisms that underlie the induction ...
Platzer, Barbara +2 more
openaire +5 more sources
The Macroautophagy Machinery in MHC Restricted Antigen Presentation
Frontiers in Immunology, 2021 Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated phagocytosis (LAP) and LC3-dependent extracellular vesicle loading and secretion (LDELS).
Christian Münz
doaj +1 more source
Intracellular transport routes for MHC class I and their relevance for antigen cross-presentation
Frontiers in Immunology, 2015 Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and in the maintenance of immune tolerance.
Cézaire Aimé Adiko +4 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Heat shock proteins 90 kDa (Hsp90s) were originally identified as stress-responsive proteins and described to participate in several homeostatic processes.
Mariana G. Corigliano +6 more
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